WH0000922M1
Monoclonal Anti-CD5L antibody produced in mouse
clone 1C8, purified immunoglobulin, buffered aqueous solution
别名:
Anti-API6, Anti-CD5 antigen-like (scavenger receptor cysteine rich family), Anti-PRO229, Anti-SPALPHA, Anti-Spalpha
生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
1C8, monoclonal
表单
buffered aqueous solution
种属反应性
human
技术
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
同位素/亚型
IgG2aκ
GenBank登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CD5L(922)
一般描述
CD5 molecule like (CD5L), also known as apoptosis inhibitor of macrophage (AIM), is encoded by the gene mapped to human chromosome 1q23.1. CD5L is a member of the scavenger receptor cysteine-rich (SRCR) superfamily. It is a soluble protein expressed generally by macrophages in lymphoid and inflamed tissues. This protein is characterized with a potential region of O-linked glycosylation in a Pro-Ser-Thr-rich polypeptide, separating SRCR domains 1 and 2.
免疫原
CD5L (AAH33586, 41 a.a. ~ 140 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
QKGQWGTVCDDGWDIKDVAVLCRELGCGAASGTPSGILYEPPAEKEQKVLIQSVSCTGTEDTLAQCEQEEVYDCSHDEDAGASCENPESSFSPVPEGVRL
Sequence
QKGQWGTVCDDGWDIKDVAVLCRELGCGAASGTPSGILYEPPAEKEQKVLIQSVSCTGTEDTLAQCEQEEVYDCSHDEDAGASCENPESSFSPVPEGVRL
生化/生理作用
CD5 molecule like (CD5L) controls lipid metabolism and regulates T-helper (Th) 17 cell pathogenicity. In addition, it also has an ability to regulate leukocyte migration and inflammatory responses. Overexpression of the protein has been observed in atopic dermatitis (AD) patients. Thus, it can be used as a potential biomarker for AD.
外形
Solution in phosphate buffered saline, pH 7.4
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
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储存分类代码
12 - Non Combustible Liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
1q23. 1 homozygous deletion and downregulation of Fc receptor-like family genes confer poor prognosis in chronic lymphocytic leukemia
Daniele G, et al.
Clinical and Experimental Medicine, 1-7 (2019)
AIM/CD5L: a key protein in the control of immune homeostasis and inflammatory disease
Sanjurjo L, et al.
Journal of Leukocyte Biology, 98(2), 173-184 (2015)
CD5L/AIM regulates lipid biosynthesis and restrains Th17 cell pathogenicity
Wang C, et al.
Cell, 163(6), 1413-1427 (2015)
Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers
Kim W, et al.
Experimental & Molecular Medicine, 40(6), 677-677 (2008)
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