WH0005291M1
Monoclonal Anti-PIK3CB antibody produced in mouse
clone 4H2, purified immunoglobulin, buffered aqueous solution
别名:
Anti-DKFZp779K1237, Anti-PI3K, Anti-PI3Kbeta, Anti-PIK3C1, Anti-p110BETA, Anti-phosphoinositide-3-kinase, catalytic, beta polypeptide
生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
4H2, monoclonal
表单
buffered aqueous solution
种属反应性
human
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
proximity ligation assay: suitable
western blot: 1-5 μg/mL
同位素/亚型
IgG2aκ
GenBank登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... PIK3CB(5291)
一般描述
PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit β) belongs to the phosphatidylinositol 3-kinase (PI3 kinase) family. It is located on human chromosome 3q22.
免疫原
PIK3CB (NP_006210, 147 a.a. ~ 256 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
EFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEY
Sequence
EFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEY
生化/生理作用
PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit β) controls several cellular processes like cell survival, proliferation, cell cycle progression, angiogenesis, invasion and metastasis. It plays a major role in the development of CRC (colorectal cancer).
外形
Solution in phosphate buffered saline, pH 7.4
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone
Dos Santos C, et al.
Nature Genetics, 36(7), 720-724 (2004)
Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma
Guillard S, et al.
Cell Cycle, 8(3), 443-453 (2009)
Feifei Wen et al.
International journal of clinical and experimental pathology, 7(11), 8295-8303 (2015-01-01)
The phosphoinositide 3-kinases (PI3Ks) are a critical family of signaling enzymes that participate in many cellular processes that promote the transformation of a normal cell into a cancer cell. These processes include cancer cell proliferation, migration, and invasion. However, the
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