WH0005291M1
Monoclonal Anti-PIK3CB antibody produced in mouse
clone 4H2, purified immunoglobulin, buffered aqueous solution
别名:
Anti-DKFZp779K1237, Anti-PI3K, Anti-PI3Kbeta, Anti-PIK3C1, Anti-p110BETA, Anti-phosphoinositide-3-kinase, catalytic, beta polypeptide
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
4H2, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: suitable, proximity ligation assay: suitable, western blot: 1-5 μg/mL
isotype
IgG2aκ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... PIK3CB(5291)
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General description
PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit β) belongs to the phosphatidylinositol 3-kinase (PI3 kinase) family. It is located on human chromosome 3q22.
Immunogen
PIK3CB (NP_006210, 147 a.a. ~ 256 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
EFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEY
Sequence
EFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEY
Biochem/physiol Actions
PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit β) controls several cellular processes like cell survival, proliferation, cell cycle progression, angiogenesis, invasion and metastasis. It plays a major role in the development of CRC (colorectal cancer).
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma
Guillard S, et al.
Cell Cycle, 8(3), 443-453 (2009)
A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone
Dos Santos C, et al.
Nature Genetics, 36(7), 720-724 (2004)
Feifei Wen et al.
International journal of clinical and experimental pathology, 7(11), 8295-8303 (2015-01-01)
The phosphoinositide 3-kinases (PI3Ks) are a critical family of signaling enzymes that participate in many cellular processes that promote the transformation of a normal cell into a cancer cell. These processes include cancer cell proliferation, migration, and invasion. However, the
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