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Merck
CN

WH0007157M1

Sigma-Aldrich

Monoclonal Anti-TP53 antibody produced in mouse

clone 2C3, purified immunoglobulin, buffered aqueous solution

别名:

Anti-LFS1, Anti-TRP53, Anti-p53, Anti-tumor protein p53 (Li-Fraumeni syndrome)

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关于此项目

MDL编号:
MFCD00164709
UNSPSC代码:
12352203
NACRES:
NA.41

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生物来源

mouse

偶联物

unconjugated

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

2C3, monoclonal

表单

buffered aqueous solution

种属反应性

human

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL

同位素/亚型

IgG1κ

GenBank登记号

BC003596

UniProt登记号

P04637

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... TP53(7157)

一般描述

p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.

免疫原

TP53 (AAH03596, 94 a.a. ~ 201 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNL

生化/生理作用

Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
09146-2C3
09302-2C3
07110-2C3

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Cell Cycle and Apoptosis
Bruna Pucci, et.al
Neoplasia, 2(4), 291-299 (2000)
Multiple myeloma involving central nervous system: high frequency of chromosome 17p13.1 (p53) deletions
Hong Chang, et.al
British Journal of Haematology, 127(3), 280-284 (2004)
Multiple myeloma involving central nervous system: high frequency of chromosome 17p13.1 (p53) deletions.
Chang H
British Journal of Haematology, 127(3), 280-284 (2004)
Cell Cycle and Apoptosis
Bruna Pucci
Neoplasia, 2(4), 291-299 (2000)

商品

p53: DNA Damage Response and Cancer

p53 regulates gene expression, cell cycle control and functions as a tumor suppressor. Inactivation of p53 is closely tied to cancer development.

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