WH0255488M2
Monoclonal Anti-IBRDC2 antibody produced in mouse
clone 4F1, purified immunoglobulin, buffered aqueous solution
别名:
Anti-IBR domain containing 2, Anti-KIAA0161, Anti-MGC71786, Anti-bA528A10.3, Anti-p53RFP
生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
4F1, monoclonal
表单
buffered aqueous solution
种属反应性
human
技术
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL
同位素/亚型
IgG2aκ
GenBank登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... RNF144B(255488)
一般描述
IBR domain containing 2 (IBRDC2) is also known as ring finger protein 144B (RNF144B). It is an E3 ubiquitin ligase which is expressed in the ovaries, testis and spleen. The 303 amino acid protein is localized to the mitochondria, Golgi apparatus, cell membrane and cytoplasm. The gene encoding it is located on human chromosome 6p22.3.
免疫原
IBRDC2 (NP_877434, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MGSAGRLHYLAMTAENPTPGDLAPAPLITCKLCLCEQSLDKMTTLQECQCIFCTACLKQYMQLAIREGCGSPITCPDMVCLNHGTLQEAEIACLVPVDQF
Sequence
MGSAGRLHYLAMTAENPTPGDLAPAPLITCKLCLCEQSLDKMTTLQECQCIFCTACLKQYMQLAIREGCGSPITCPDMVCLNHGTLQEAEIACLVPVDQF
生化/生理作用
IBR domain containing 2 (IBRDC2) modulates the expression of the pro-apoptotic protein, Bax. It has a regulatory role in epithelial homeostasis and is involved in the stimulation of p53-dependent apoptosis.
外形
Solution in phosphate buffered saline, pH 7.4
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
F Conforti et al.
Oncogene, 32(40), 4758-4765 (2012-11-07)
ΔNp63 is a transcription factor that is critical for the development of stratified epithelia and is overexpressed or amplified in >80% of squamous cell carcinomas (SCCs). We identified the RING finger E3 ubiquitin ligase PIR2/Rnf144b as a direct transcriptional target
Hans M Albertsen et al.
PloS one, 8(3), e58257-e58257 (2013-03-09)
Endometriosis is a common gynecological condition with complex etiology defined by the presence of endometrial glands and stroma outside the womb. Endometriosis is a common cause of both cyclic and chronic pelvic pain, reduced fertility, and reduced quality-of-life. Diagnosis and
Jun Huang et al.
FEBS letters, 580(3), 940-947 (2006-01-24)
Recently, it has been shown that really interesting new gene (RING)-in between ring finger (IBR)-RING domain-containing proteins, such as Parkin and Parc, are E3 ubiquitin ligases and are involved in regulation of apoptosis. In this report, we show that p53-inducible
Giovanni Benard et al.
The EMBO journal, 29(8), 1458-1471 (2010-03-20)
Bax, a pro-apoptotic protein from the Bcl-2 family, is central to apoptosis regulation. To suppress spontaneous apoptosis, Bax must be under stringent control that may include regulation of Bax conformation and expression levels. We report that IBRDC2, an IBR-type RING-finger
Shiuh-Rong Ho et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(26), E2646-E2655 (2014-07-01)
Several ring between ring fingers (RBR) -domain proteins, such as Parkin and Parc, have been shown to be E3 ligases involved in important biological processes. Here, we identify a poorly characterized RBR protein, Ring Finger protein 144A (RNF144A), as the
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