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Merck
CN

X3503

Xenin 25 acetate salt

≥95% (HPLC)

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关于此项目

经验公式（希尔记法）:
C139H224N38O32S
化学文摘社编号:
144092-28-4
分子量:
2971.57
UNSPSC Code:
51111800
MDL number:
MFCD04041204

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InChI

1S/C139H224N38O32S/c1-15-79(10)111(132(203)169-103(137(208)209)64-77(6)7)173-126(197)101(67-85-69-152-89-41-23-22-40-87(85)89)167-130(201)107-49-34-59-176(107)135(206)96(47-33-58-151-139(147)148)163-117(188)91(43-25-29-54-141)159-129(200)106-48-35-60-177(106)136(207)102(68-86-70-149-74-154-86)168-124(195)100(66-84-38-20-17-21-39-84)166-128(199)105(73-179)171-122(193)97(62-75(2)3)156-108(182)71-153-116(187)90(42-24-28-53-140)160-131(202)110(78(8)9)172-120(191)94(46-32-57-150-138(145)146)157-114(185)80(11)155-127(198)104(72-178)170-119(190)93(45-27-31-56-143)162-133(204)112(81(12)180)174-121(192)95(50-51-109(183)184)158-123(194)99(65-83-36-18-16-19-37-83)165-118(189)92(44-26-30-55-142)161-134(205)113(82(13)181)175-125(196)98(63-76(4)5)164-115(186)88(144)52-61-210-14/h16-23,36-41,69-70,74-82,88,90-107,110-113,152,178-181H,15,24-35,42-68,71-73,140-144H2,1-14H3,(H,149,154)(H,153,187)(H,155,198)(H,156,182)(H,157,185)(H,158,194)(H,159,200)(H,160,202)(H,161,205)(H,162,204)(H,163,188)(H,164,186)(H,165,189)(H,166,199)(H,167,201)(H,168,195)(H,169,203)(H,170,190)(H,171,193)(H,172,191)(H,173,197)(H,174,192)(H,175,196)(H,183,184)(H,208,209)(H4,145,146,150)(H4,147,148,151)/t79-,80-,81+,82+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,110-,111-,112-,113-/m0/s1

InChI key

IDHVLSACPFUBDY-QCDLPZBNSA-N

assay

≥95% (HPLC)

solubility

H2O: soluble

storage temp.

−20°C

Biochem/physiol Actions

Peptide involved in the regulation of food intake that is released into the circulation from the gut mucosa after a meal. It may stimulate enzyme release from the exocrine pancreas.
Peptide involved in the regulation of food intake.

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
011M2085V
110M1725
110M1213
129K1408
119K1563

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Burton M Wice et al.
Diabetes, 61(7), 1793-1800 (2012-04-24)
Glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-stimulated insulin secretion (GSIS). This response is blunted in type 2 diabetes (T2DM). Xenin-25 is a 25-amino acid neurotensin-related peptide that amplifies GIP-mediated GSIS in hyperglycemic mice. This study determines if xenin-25 amplifies GIP-mediated GSIS
Marcin Nylec et al.
Postepy higieny i medycyny doswiadczalnej (Online), 64, 291-295 (2010-06-19)
Appetite control is a complex process regulated by both neurotransmitters, such as: appetite- increasing neuropeptide Y (NPY), Agouti related peptide (AgRP), orexins A and B, as well as appetite-suppressing propiomelanocortin (POMC) and a peptide (CART) which transcription is regulated by
Beata Mrózek et al.
Pediatric endocrinology, diabetes, and metabolism, 18(1), 5-8 (2011-01-01)
Xenin is a newly discovered peptide in humans. The concentration of xenin in human plasma increases after meals and therefore this peptide is considered as a marker of satiety. The mechanism of xenin action in humans has not been thoroughly
Jennifer H Cooke et al.
Obesity (Silver Spring, Md.), 17(6), 1135-1143 (2009-02-14)
Xenin is a 25-amino acid peptide highly homologous to neurotensin. Xenin and neurotensin are reported to have similar biological effects. Both reduce food intake when administered centrally to fasted rats. We aimed to clarify and compare the effects of these
Eun Ran Kim et al.
Neuroscience letters, 481(1), 59-63 (2010-07-06)
Xenin, a 25-amino acid gastrointestinal peptide, inhibits feeding by acting through the central nervous system. Gastrointestinal hormones reduce food intake partly by activating the brainstem and inhibiting gastric emptying. Therefore, we hypothesized that xenin delays gastric emptying through the activation
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