Y0271
Anti-YB-1 (N-terminal) antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-BP-8, Anti-CSDA2, Anti-CSDB, Anti-DBPB, Anti-MDR-NF1, Anti-NSEP1, Anti-Y BOX binding protein 1, Anti-YBOX1
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa (An additional weaker band may be seen in some extract preparations.)
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
western blot: 0.5-1 μg/mL using PC-12 cell lysates, western blot: 1-2 μg/mL using HEK-293T or NIH-3T3 cell lysates
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... YBX1(4904)
mouse ... Ybx1(22608)
rat ... Ybx1(500538)
General description
YB-1 (Y-box-binding protein 1) is a member of the evolutionary conserved Cold-Sock Domain (CSD) proteins. It is ubiquitously expressed in adult tissues and throughout embryogenesis.
Immunogen
synthetic peptide corresponding to amino acidds 137-150 of human YB-1, conjugated to KLH. The corresponding sequence is identical in rat and mouse proteins.
Application
Anti-YB-1 (N-terminal) antibody has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
YB-1 (Y-box-binding protein 1) plays a major role in a wide variety of cellular functions such as transcriptional and translation regulation, DNA repair, drug resistance and stress responses. YB-1 deficient embryos die during late embryonic development and exhibit a runting phenotype.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
The major mRNA-associated protein YB-1 is a potent 5? cap-dependent mRNA stabilizer
Evdokimova V, et al.
The Embo Journal, 20(19), 5491-5502 (2001)
The atypical dual specificity phosphatase hYVH1 associates with multiple Ribonucleoprotein particles
Geng Q, et al.
The Journal of biological chemistry, 292(2), 539-550 (2017)
YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence
Lu Z H, et al.
Molecular and Cellular Biology, 25(11), 4625-4637 (2005)
Qiudi Geng et al.
The Journal of biological chemistry, 292(2), 539-550 (2016-11-20)
Human YVH1 (hYVH1), also known as dual specificity phosphatase 12 (DUSP12), is a poorly characterized atypical dual specificity phosphatase widely conserved throughout evolution. Recent findings have demonstrated that hYVH1 expression affects cellular DNA content and is a novel cell survival
相关内容
Instructions
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