Y0271
Anti-YB-1 (N-terminal) antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-BP-8, Anti-CSDA2, Anti-CSDB, Anti-DBPB, Anti-MDR-NF1, Anti-NSEP1, Anti-Y BOX binding protein 1, Anti-YBOX1
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~50 kDa (An additional weaker band may be seen in some extract preparations.)
种属反应性
mouse, rat, human
浓度
~1 mg/mL
技术
western blot: 0.5-1 μg/mL using PC-12 cell lysates
western blot: 1-2 μg/mL using HEK-293T or NIH-3T3 cell lysates
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... YBX1(4904)
mouse ... Ybx1(22608)
rat ... Ybx1(500538)
一般描述
YB-1 (Y-box-binding protein 1) is a member of the evolutionary conserved Cold-Sock Domain (CSD) proteins. It is ubiquitously expressed in adult tissues and throughout embryogenesis.
免疫原
synthetic peptide corresponding to amino acidds 137-150 of human YB-1, conjugated to KLH. The corresponding sequence is identical in rat and mouse proteins.
应用
Anti-YB-1 (N-terminal) antibody has been used in immunoblotting and immunofluorescence.
生化/生理作用
YB-1 (Y-box-binding protein 1) plays a major role in a wide variety of cellular functions such as transcriptional and translation regulation, DNA repair, drug resistance and stress responses. YB-1 deficient embryos die during late embryonic development and exhibit a runting phenotype.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
The major mRNA-associated protein YB-1 is a potent 5? cap-dependent mRNA stabilizer
Evdokimova V, et al.
The Embo Journal, 20(19), 5491-5502 (2001)
The atypical dual specificity phosphatase hYVH1 associates with multiple Ribonucleoprotein particles
Geng Q, et al.
The Journal of biological chemistry, 292(2), 539-550 (2017)
YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence
Lu Z H, et al.
Molecular and Cellular Biology, 25(11), 4625-4637 (2005)
Qiudi Geng et al.
The Journal of biological chemistry, 292(2), 539-550 (2016-11-20)
Human YVH1 (hYVH1), also known as dual specificity phosphatase 12 (DUSP12), is a poorly characterized atypical dual specificity phosphatase widely conserved throughout evolution. Recent findings have demonstrated that hYVH1 expression affects cellular DNA content and is a novel cell survival
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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