Y1521
YS-49 monohydrate
≥98% (HPLC)
别名:
1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C20H19NO2 · HBr · H2O
化学文摘社编号:
分子量:
404.30
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
solid
溶解性
H2O: >10 mg/mL
储存温度
2-8°C
SMILES字符串
O.Br.Oc1cc2CCNC(Cc3cccc4ccccc34)c2cc1O
InChI
1S/C20H19NO2.BrH.H2O/c22-19-11-15-8-9-21-18(17(15)12-20(19)23)10-14-6-3-5-13-4-1-2-7-16(13)14;;/h1-7,11-12,18,21-23H,8-10H2;1H;1H2
InChI key
QHCUNMLYODPTIU-UHFFFAOYSA-N
生化/生理作用
YS-49 protects cells from oxidant injury; anti-inflammatory agent; activator of PI3K/Akt signaling. YS-49, an analog of higenamine, induces heme oxygenase (HO-1) in endothelial cells and protects cells from oxidant injury. The compound was reported to inhibit Ang II-stimulated VSMC proliferation through HO-1 production, which inhibits both the JNK pathway and ROS production. A study (JPET) reported that CKD712 (S-YS-49) confer cardiac protection and anti-inflammatory via activation of the PI3K signal pathway. These effects were antagonized by a PI3K inhibitor, wortmannin.
特点和优势
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
商品
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
实验方案
We offer many products related to PKB/Akt for your research needs.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持