Y4877
YM 976
≥98% (HPLC)
别名:
4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one
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关于此项目
经验公式（希尔记法）:
C17H16N3OCl
化学文摘社编号:
分子量:
313.78
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
solid
颜色
yellow
mp
132.7-134.0 °C (lit.)
溶解性
DMSO: ≥10 mg/mL
储存温度
2-8°C
SMILES字符串
CCN1C(=O)N=C(c2cccc(Cl)c2)c3ccc(CC)nc13
InChI
1S/C17H16ClN3O/c1-3-13-8-9-14-15(11-6-5-7-12(18)10-11)20-17(22)21(4-2)16(14)19-13/h5-10H,3-4H2,1-2H3
InChI key
MNHXYNNKDDXKNP-UHFFFAOYSA-N
生化/生理作用
Phosphodiesterase type IV (PDE4) inhibitor. Anti-inflammatory activity without emesis. Related to asthma.
Phosphodiesterase type IV (PDE4) inhibitor. Exhibits anti-inflammatory activity without emesis. PDE4 inhibitors are of interest for asthma.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Massimo Nabissi et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 105, 1248-1253 (2018-07-20)
Chronic obstructive pulmonary disease (COPD) is a respiratory disorder characterized by a progressive and irreversible airflow limitation. COPD is associated to a chronic inflammatory response with infiltration of inflammatory cells in the surface epithelium of large airways and abnormalities in
Will McDonough et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(9), 12533-12548 (2020-08-02)
Inhibitors of cAMP-phosphodiesterase 4 (PDE4) exert a number of promising therapeutic benefits, but adverse effects, in particular emesis and nausea, have curbed their clinical utility. Here, we show that PAN-selective inhibition of PDE4, but not inhibition of PDE3, causes a
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