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Merck
CN

Z2625

Sigma-Aldrich

Zomepirac sodium salt

别名:

5-(p-Chlorobenzoyl)-1,4-dimethylpyrrole-2-acetic acid sodium-potassium salt

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关于此项目

线性分子式:
C15H13ClNO3Na
化学文摘社编号:
64092-48-4
分子量:
313.71
EC 号:
264-669-2
MDL编号:
MFCD00057223
UNSPSC代码:
12161501
PubChem化学物质编号:
24902176
NACRES:
NA.77

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质量水平

200

SMILES字符串

Cc1cc(CC(=O)O[Na])n(C)c1C(=O)c2ccc(Cl)cc2

InChI

1S/C15H14ClNO3.Na/c1-9-7-12(8-13(18)19)17(2)14(9)15(20)10-3-5-11(16)6-4-10;/h3-7H,8H2,1-2H3,(H,18,19);/q;+1/p-1

InChI key

SEEXPXUCHVGZGU-UHFFFAOYSA-M

应用

An NSAID. Circumvents MRP-mediated multidrug resistance. Significantly increases the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300,H311 + H331

危险分类

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000366823
0000366823
0000274405
0000274405
116H0298

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M Wang et al.
Life sciences, 68(5), 525-537 (2001-02-24)
Acyl glucuronides are reactive electrophilic metabolites of carboxylate drugs, capable of undergoing hydrolysis, rearrangement and covalent binding reactions with proteins in vivo. Such covalent drug-protein adducts may be prerequisites for certain idiosyncratic immune and toxic responses in susceptible individuals. The
Mark P Grillo et al.
Drug metabolism and disposition: the biological fate of chemicals, 31(11), 1429-1436 (2003-10-23)
Zomepirac (ZP), a nonsteroidal anti-inflammatory drug that was withdrawn from use, is metabolized to zomepirac-1-O-acyl-glucuronide (ZP-1-O-G), a chemically reactive conjugate that has been implicated in the toxicity of the drug. In the present studies, we investigated the ability of ZP
Qing Chen et al.
Drug metabolism and disposition: the biological fate of chemicals, 34(1), 145-151 (2005-10-28)
Although zomepirac (ZP) and tolmetin (TM) induce anaphylactic reactions and form reactive acyl glucuronides, a direct link between the two events remains obscure. We report herein that, in addition to acyl glucuronidation, both drugs are subject to oxidative bioactivation. Following
M Wang et al.
Life sciences, 68(7), 785-797 (2001-02-24)
The nonsteroidal anti-inflammatory drug zomepirac (ZP) is metabolised to a chemically reactive acyl glucuronide conjugate (ZAG) which can form covalent adducts with proteins. In vivo, such adducts could initiate immune or toxic responses. In rats given ZP, the major band
M J Bailey et al.
Journal of pharmacological and toxicological methods, 41(1), 27-32 (1999-10-03)
The covalent binding of drugs or their metabolites to proteins is of increasing interest in the investigation of the toxicity of these compounds. Recent attention on biological consequences of protein adduct formation with carboxylate drugs, derived via their reactive acyl
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