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Per- and polyfluorinated alkyl substances (PFAS) represent a class of synthetic compounds that have gained significant attention due to their widespread use and environmental persistence. Known for their toxicity, PFAS pose serious challenges to both public health and the environment, making effective testing essential. The United States Environmental Protection Agency (US EPA) has established several guidelines for PFAS testing regulations, emphasizing the need for rigorous analytical methods.




Testing for PFAS requires solvents, such as water, acetonitrile, and methanol of exceptionally high purity, which are utilized in both analytical and preparative stages of the analysis. The high sensitivity of liquid chromatography-mass spectrometry (LC-MS) instruments, combined with the need for trace-level detection of PFAS, necessitates the use of solvents that are free from PFAS contamination. Any presence of PFAS in these solvents can lead to misleading results, resulting in false positives or an overestimation of PFAS levels, ultimately compromising the validity of analytical results and conclusions. Therefore, ensuring solvent purity is paramount for accurate and reliable PFAS analysis.




LiChrosolv® solvents, tested for PFAS methods, are engineered to meet the demands of this critical application. Each batch undergoes rigorous testing against all analytes outlined in EPA methods EPA 533, EPA 537.1, and EPA 1633. These solvents are designed to minimize background interference and contain no PFAS compounds above the limit values defined by each EPA method. This ensures reliable and effective testing, facilitating the identification and quantitation of PFAS analytes while eliminating the risk of false positive or negative results in LC-MS/MS analysis.

LiChrosolv® PFAS-tested solvents are suitable for testing PFAS in drinking water according to EPA methods 533 and 537.1. These solvents can also be used for testing PFAS in other aqueous matrices including wastewater, surface water, groundwater, and landfill leachate, as well as for soil, sediment, biosolids, and fish and shellfish following the EPA method 1633.
PFAS Testing Features
- QC Batch Tested: 40 PFAS analytes tested according to EPA 533 (25 analytes), EPA 537.1 (18 analytes), and EPA 1633 (40 analytes).
-Lot to Lot Consistency: Multiple batches validated by a third-party accredited testing laboratory and internal laboratories.

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany