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Merck
CN

PHL89811

雷公藤内酯

phyproof® Reference Substance

别名:

PG 490

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关于此项目

经验公式(希尔记法):
C20H24O6
化学文摘社编号:
分子量:
360.40
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
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产品名称

雷公藤内酯, phyproof® Reference Substance

InChI

1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11?,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1

SMILES string

O=C1OCC2=C1CC[C@]3(C)[C@]4(O5)[C@@H]5[C@H]6[C@@](O6)(C(C)C)[C@@H](O)[C@]4(O7)[C@@H]7C[C@]32[H]

InChI key

DFBIRQPKNDILPW-KTGKZQHOSA-N

grade

primary reference standard

product line

phyproof® Reference Substance

assay

≥98.0% (HPLC)

manufacturer/tradename

PhytoLab

application(s)

food and beverages

format

neat

storage temp.

2-8°C

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Biochem/physiol Actions

雷公藤内酯是一种二萜三环氧化物,是中草药雷公藤(Tripterygium wilfordii) (TwHF)提取物中的主要活性成分 。它是一种有效的免疫抑制剂和抗炎药。雷公藤内酯已被证明在嘌呤盒/核因子和NF-κB介导的转录激活水平上抑制活化T细胞中IL-2的表达。它与环孢菌素A协同可促进动物模型中的移植物的存活,和抑制同种异体骨髓移植中的移植物抗宿主病。此外,它可诱导肿瘤细胞凋亡,并可部分通过抑制c-IAP2和c-IAP1,来增强肿瘤坏死因子(TNFα)诱导的细胞凋亡。

General description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Legal Information

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Yicheng Long et al.
Nature genetics, 52(9), 931-938 (2020-07-08)
Many chromatin-binding proteins and protein complexes that regulate transcription also bind RNA. One of these, Polycomb repressive complex 2 (PRC2), deposits the H3K27me3 mark of facultative heterochromatin and is required for stem cell differentiation. PRC2 binds RNAs broadly in vivo
Tsung-Han S Hsieh et al.
Molecular cell, 78(3), 539-553 (2020-03-28)
Whereas folding of genomes at the large scale of epigenomic compartments and topologically associating domains (TADs) is now relatively well understood, how chromatin is folded at finer scales remains largely unexplored in mammals. Here, we overcome some limitations of conventional

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