1287030
USP
4-氯-5-氨磺酰邻氨基苯甲酸
United States Pharmacopeia (USP) Reference Standard
别名:
4-Chloro-5-sulfamoylanthranilic acid
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关于此项目
经验公式（希尔记法）:
C7H7ClN2O4S
化学文摘社编号:
分子量:
250.66
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
pharmaceutical primary standard
API类
furosemide
制造商/商品名称
USP
mp
267 °C (dec.) (lit.)
应用
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
Nc1cc(Cl)c(cc1C(O)=O)S(N)(=O)=O
InChI
1S/C7H7ClN2O4S/c8-4-2-5(9)3(7(11)12)1-6(4)15(10,13)14/h1-2H,9H2,(H,11,12)(H2,10,13,14)
InChI key
QQLJBZFXGDHSRU-UHFFFAOYSA-N
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Furosemide Related Compound B USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
分析说明
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
其他说明
Sales restrictions may apply.
Thin-layer chromatographic determination of furosemide and 4-chloro-5-sulfamoyl anthranilic acid in plasma and urine.
B Wesley-Hadzija et al.
Journal of chromatography, 229(2), 425-432 (1982-05-14)
F Andreasen et al.
Acta pharmacologica et toxicologica, 49(3), 223-229 (1981-09-01)
Three principles for the use of HPLC with spectrophotometric detection to determine the concentration of furosemide and of 4-chloro-5-sulfamoyl anthranilic acid (CSA) were studied. A reversed phase microbondapack C18 column was used for the separation of either unchanged furosemide (I)
H Nakahama et al.
Nephron, 53(2), 138-141 (1989-01-01)
Furosemide is known to potentiate gentamicin nephrotoxicity. The mechanism of potentiation is unclear. In our previous studies, we demonstrated that furosemide enhanced gentamicin accumulation in rabbit renal tissues when injected as a bolus [Kidney int. 33:363, 1988] or repeatedly subcutaneously
The binding of furosemide to serum proteins in elderly patients: displacing effect of phenprocoumon.
F Andreasen et al.
Acta pharmacologica et toxicologica, 47(3), 202-207 (1980-09-01)
The percentual binding of furosemide (5 micrograms/ml) was slightly but significantly lower in serum from elderly patients than in serum from normal blood donors (96.5 +/- 0.7 versus 97.9 +/- 0.3). A significant positive correlation was demonstrated between protein binding
M Hezari et al.
Drug metabolism and disposition: the biological fate of chemicals, 20(6), 882-888 (1992-11-01)
Furosemide (Lasix), a widely used diuretic, is metabolized by the fungus Cunninghamella elegans (ATCC 36112) to 4-chloro-5-sulfamoyl anthranilic acid (CSA), a metabolite also present in mammalian systems. This metabolite was isolated following preparative-scale incubations of C. elegans, and was characterized
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