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安全信息

1441301

USP

美托洛尔 (+)-酒石酸盐

United States Pharmacopeia (USP) Reference Standard

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别名:
(±)1-(异丙氨基)-3-[p-(β-甲氧基乙基)苯氧基] -2-丙醇 (+)-酒石酸盐, Lopressor
线性分子式:
(C15H25NO3)2 · C4H6O6
CAS号:
56392-17-7
分子量:
684.81
MDL编号:
MFCD00056257
PubChem化学物质编号:
329750297
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

metoprolol

制造商/商品名称

USP

应用

pharmaceutical (small molecule)

格式

neat

SMILES字符串

O[C@H]([C@@H](O)C(O)=O)C(O)=O.COCCc1ccc(OCC(O)CNC(C)C)cc1.COCCc2ccc(OCC(O)CNC(C)C)cc2

InChI

1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1

InChI key

YGULWPYYGQCFMP-CEAXSRTFSA-N

基因信息

human ... ADRB1(153)

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Metoprolol tartrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

相关产品

产品编号
说明
价格

Y0000145

美托洛尔杂质A, European Pharmacopoeia (EP) Reference Standard

1441243

Metoprolol Related Compound B, United States Pharmacopeia (USP) Reference Standard

1441254

Metoprolol Related Compound C, United States Pharmacopeia (USP) Reference Standard

1441265

Metoprolol Related Compound D, United States Pharmacopeia (USP) Reference Standard

1441298

Metoprolol succinate, United States Pharmacopeia (USP) Reference Standard

1441232

(±)-1-（乙胺基）-3-[4-（2-甲氧基乙基）苯氧基] -2-丙醇, United States Pharmacopeia (USP) Reference Standard

1441287

Metoprolol fumarate, United States Pharmacopeia (USP) Reference Standard

BP540

美托洛尔 (+)-酒石酸盐, British Pharmacopoeia (BP) Reference Standard

PHR9038

4-(2-甲氧基乙基)苯酚, reference material

PHR9039

2-(4-羟苯基)乙醇, reference material

PHR9068

Metoprolol EP Impurity H, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2509

(±)-1-（乙胺基）-3-[4-（2-甲氧基乙基）苯氧基] -2-丙醇, Pharmaceutical Secondary Standard; Certified Reference Material

PHR9101

Metoprolol EP Impurity E, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2510

Metoprolol Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2511

Metoprolol succinate, Pharmaceutical Secondary Standard; Certified Reference Material

PHR3046

Metoprolol Fumarate, pharmaceutical secondary standard, certified reference material

象形图

Health hazardEnvironment
GHS08,GHS09

警示用语：

Warning

危险声明

H361d - H411

危险分类

Aquatic Chronic 2 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

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C Narendra et al.
AAPS PharmSciTech, 7(2), E34-E34 (2006-06-27)
The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing metoprolol tartrate (MT) as a model drug by the optimization technique. A 2(3) factorial design was employed in formulating the GFDDS with
Design and evaluation of mucoadhesive buccal drug delivery systems containing metoprolol tartrate.
Ramana, M. V., C. Nagda, and M. Himaja.
Indian Journal of Pharmaceutical Sciences, 69.4, 515-515 (2007)
Wenhuan Li et al.
Medicine, 93(28), e329-e329 (2014-12-20)
The sensitivity and specificity of 5 different image sets of dual-energy computed tomography (DECT) for the detection of first-pass myocardial perfusion defects have not systematically been compared using positron emission tomography (PET) as a reference standard. Forty-nine consecutive patients, with
Reply: Carvedilol versus metoprolol, but which metoprolol? Effect on inappropriate cardioverter-defibrillator therapy.
Martin H Ruwald et al.
Journal of the American College of Cardiology, 63(18), 1933-1934 (2014-02-04)
I S Hamadeh et al.
Clinical pharmacology and therapeutics, 96(2), 175-181 (2014-03-19)
Metoprolol is a selective β-1 adrenergic receptor blocker that undergoes extensive metabolism by the polymorphic enzyme cytochrome P450 2D6 (CYP2D6). Our objective was to investigate the influence of CYP2D6 polymorphisms on the efficacy and tolerability of metoprolol tartrate. Two hundred
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