所有图片(1)

文件

1598303

USP

雷米普利

Name: 雷米普利
Brand: USP

United States Pharmacopeia (USP) Reference Standard

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所有图片(1)

别名:

Tritace, [2S,3aS,6aS]-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid

经验公式（希尔记法）:

C₂₃H₃₂N₂O₅

CAS号:

87333-19-5

分子量:

416.51

MDL编号:

MFCD00865775

PubChem化学物质编号:

329751020

NACRES:

NA.24

等级

pharmaceutical primary standard

API family

ramipril

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES string

O=C(N1[C@](CCC2)([H])[C@]2([H])C[C@H]1C(O)=O)[C@H](C)N[C@H](C(OCC)=O)CCC3=CC=CC=C3

InChI

1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1

InChI key

HDACQVRGBOVJII-JBDAPHQKSA-N

Gene Information

human ... ACE(1636)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

Angiotensin converting enzyme (ACE) inhibitor.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

Sales restrictions may apply.

1598314

1598347

1598323

1598338

BP751

雷米普利, British Pharmacopoeia (BP) Reference Standard

BP754

Ramipril impurity K, British Pharmacopoeia (BP) Reference Standard

象形图

GHS08

警示用语：

Danger

危险声明

H360FD

预防措施声明

P201 - P202 - P280 - P308 + P313 - P405 - P501

危险分类

Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

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MMYOMAG-74K-13

1000309185

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索取COA

Ramipril: a review of its use in the prevention of cardiovascular outcomes.

Gregory T Warner et al.

Drugs, 62(9), 1381-1405 (2002-06-22)

Ramipril, an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which is rapidly hydrolysed after absorption to the active metabolite ramiprilat. Earlier trials have shown that ACE inhibitors, when given to patients with low ejection fractions, have reduced the relative risk

Ramipril in the treatment of vascular diseases.

Michael J Rokoss et al.

Expert opinion on pharmacotherapy, 6(11), 1911-1919 (2005-09-08)

Ramipril is an angiotensin-converting enzyme inhibitor that has been extensively studied in randomised, controlled clinical trials in patients with cardiovascular diseases. Therapy with ramipril in patients with various cardiovascular disorders has demonstrated significant and clinically important reductions in cardiovascular death

Ramipril-induced liver injury: case report and review of the literature.

Antonios Douros et al.

American journal of hypertension, 26(9), 1070-1075 (2013-06-12)

Ramipril, an inhibitor of the angiotensin-converting enzyme (ACEI), is a drug commonly used in the therapy of hypertension. ACEI-induced hepatotoxicity is rare, and most of the reported cases are associated with captopril. Here, we present the first case of ramipril-induced

The ongoing telmisartan alone and in combination with ramipril global endpoint trial program.

Thomas Unger

The American journal of cardiology, 91(10A), 28G-34G (2003-06-05)

The renin-angiotensin system evolved to maintain volume homeostasis and blood pressure and to prevent ischemia during acute volume loss. But in the present age, these mechanisms are redundant, and the clinical significance of angiotensin II results from its pathologic effects

Clinical pharmacokinetics of ramipril.

S Meisel et al.

Clinical pharmacokinetics, 26(1), 7-15 (1994-01-01)

Ramipril is a long-acting nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor introduced for clinical use about a decade ago. Ramipril is a prodrug that undergoes de-esterification in the liver to form ramiprilat, its active metabolite. Ramipril rapidly distributes to all tissues

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