V900351
5-氟胞嘧啶
Vetec™, reagent grade, 99%
别名:
4-氨基-5-氟-2(1H)-嘧啶酮, 氟胞嘧啶
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关于此项目
经验公式（希尔记法）:
C4H4FN3O
化学文摘社编号:
分子量:
129.09
EC Number:
217-968-7
UNSPSC Code:
41116107
PubChem Substance ID:
Beilstein/REAXYS Number:
127285
MDL number:
产品名称
5-氟胞嘧啶, Vetec™, reagent grade, 99%
InChI key
XRECTZIEBJDKEO-UHFFFAOYSA-N
InChI
1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
SMILES string
NC1=NC(=O)NC=C1F
grade
reagent grade
product line
Vetec™
assay
99%
mp
298-300 °C (dec.) (lit.)
storage temp.
2-8°C
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Biochem/physiol Actions
具有抗真菌活性的核苷类似物。 5-FC由胞嘧啶脱氨基酶脱氨，可产生5-氟尿嘧啶，导致RNA密码错编。 5-氟尿嘧啶可抑制DNA和RNA的合成，干扰核糖体蛋白质合成。
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
A D Hartkopf et al.
Gynecologic oncology, 130(2), 362-368 (2013-05-17)
To preclinical assess the feasibility of combining oncolytic measles vaccine virus (MeV) with suicide gene therapy for ovarian cancer treatment. We genetically engineered a recombinant MeV armed with a yeast-derived bifunctional suicide gene that encodes for cytosine deaminase and uracil
Radha Rajasingham et al.
PLoS medicine, 9(9), e1001316-e1001316 (2012-10-12)
Cryptococcal meningitis (CM) is the most common form of meningitis in Africa. World Health Organization guidelines recommend 14-d amphotericin-based induction therapy; however, this is impractical for many resource-limited settings due to cost and intensive monitoring needs. A cost-effectiveness analysis was
Hong Jun Lee et al.
Cancer letters, 335(1), 58-65 (2013-02-09)
Prostate cancer is the most common malignancy among men. Prostate cancer-related deaths are largely attributable to the development of hormone resistance in the tumor. No effective chemotherapy has yet been developed for advanced prostate cancer. It is desirable if a
Xiaorong Sun et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 105(1), 57-63 (2012-09-04)
To investigate whether hypoxia targeted bifunctional suicide gene expression-cytosine deaminase (CD) and uracil phosphoribosyltransferase (UPRT) with 5-FC treatments can enhance radiotherapy. Stable transfectants of R3327-AT cells were established which express a triple-fusion-gene: CD, UPRT and monomoric DsRed (mDsRed) controlled by
Cestmir Altaner et al.
International journal of cancer, 134(6), 1458-1465 (2013-09-17)
Suicide gene therapy mediated by mesenchymal stem cells with their ability to engraft into tumors makes these therapeutic stem cells an attractive tool to activate prodrugs directly within the tumor mass. In this study, we evaluated the therapeutic efficacy of
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