V900731
富马酸二甲酯
Vetec™, reagent grade, 97%
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线性分子式:
CH3OCOCH=CHCOOCH3
化学文摘社编号:
分子量:
144.13
EC Number:
210-849-0
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
774590
MDL number:
InChI key
LDCRTTXIJACKKU-ONEGZZNKSA-N
InChI
1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+
SMILES string
[H]\C(=C(\[H])C(=O)OC)C(=O)OC
grade
reagent grade
product line
Vetec™
assay
97%
bp
192-193 °C (lit.)
Gene Information
human ... KEAP1(9817)
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Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Markus Meissner et al.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 10(11), 793-801 (2012-08-18)
Fumaric acid esters have been used successfully in the therapy of psoriasis vulgaris since 1959. In the last 17 years, many of the underlying mechanisms of anti-psoriatic action, such as a Th1/Th2 shift, a suppression of important leukocyte adhesion molecules
Athina Papadopoulou et al.
Expert opinion on investigational drugs, 19(12), 1603-1612 (2010-11-12)
One of the disadvantages of currently available disease-modifying drugs (DMDs) for multiple sclerosis (MS) is their parenteral administration. Moreover, efficacy is only partial. Most patients treated with first-line DMDs do not remain relapse-free. There is a need for new oral
Christiane Reick et al.
Experimental neurology, 257, 50-56 (2014-04-16)
Despite recent advances in development of treatments for multiple sclerosis, there is still an unmet need for more effective and also safe therapies. Based on the modes of action of interferon-beta (IFN-β) and dimethyl fumarate (DMF), we hypothesized that anti-inflammatory
Michael D Carrithers
Clinical therapeutics, 36(12), 1938-1945 (2014-09-15)
The purpose of this review is to discuss the selection and use of disease- modifying treatments for patients with relapsing forms of multiple sclerosis (MS). PubMed was searched (1966-2014) using the terms multiple sclerosis, treatment, interferon, glatiramer acetate, dimethyl fumarate
Ralf A Linker et al.
Current neurology and neuroscience reports, 13(11), 394-394 (2013-09-26)
Dimethyl fumarate is an orally available treatment option for relapsing-remitting multiple sclerosis (MS) in a new formulation with improved gastroenteric coating. The mode of action comprises immunomodulatory effects and an activation of nuclear (erythroid-derived 2) related factor mediated antioxidative response
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