等级
reagent grade
产品线
Vetec™
方案
97%
沸点
192-193 °C (lit.)
mp
102-106 °C (lit.)
SMILES字符串
[H]\C(=C(\[H])C(=O)OC)C(=O)OC
InChI
1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+
InChI key
LDCRTTXIJACKKU-ONEGZZNKSA-N
基因信息
human ... KEAP1(9817)
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法律信息
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Alexander J Gill et al.
Critical reviews in immunology, 33(4), 307-359 (2013-08-27)
The persistence of chronic immune activation and oxidative stress in human immunodeficiency virus (HIV)-infected, antiretroviral drug-treated individuals are major obstacles to fully preventing HIV disease progression. The immune modulator and antioxidant dimethyl fumarate (DMF) is effective in treating immune-mediated diseases
Markus Meissner et al.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 10(11), 793-801 (2012-08-18)
Fumaric acid esters have been used successfully in the therapy of psoriasis vulgaris since 1959. In the last 17 years, many of the underlying mechanisms of anti-psoriatic action, such as a Th1/Th2 shift, a suppression of important leukocyte adhesion molecules
Christiane Reick et al.
Experimental neurology, 257, 50-56 (2014-04-16)
Despite recent advances in development of treatments for multiple sclerosis, there is still an unmet need for more effective and also safe therapies. Based on the modes of action of interferon-beta (IFN-β) and dimethyl fumarate (DMF), we hypothesized that anti-inflammatory
Michael D Carrithers
Clinical therapeutics, 36(12), 1938-1945 (2014-09-15)
The purpose of this review is to discuss the selection and use of disease- modifying treatments for patients with relapsing forms of multiple sclerosis (MS). PubMed was searched (1966-2014) using the terms multiple sclerosis, treatment, interferon, glatiramer acetate, dimethyl fumarate
Hui Chen et al.
The Journal of clinical investigation, 124(5), 2188-2192 (2014-04-03)
Taken orally, the drug dimethyl fumarate (DMF) has been shown to improve functional outcomes for patients with MS; however, it is unclear how DMF mediates a protective effect. DMF and, more so, its active metabolite, monomethyl fumarate, are known agonists
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