V900926
氟维司群
Vetec™, reagent grade, >98%
别名:
氟维司群, (7α,17β)-7-[9-[(4,4,5,5,5-五氟戊基)亚磺酰基]壬基]雌-1,3,5(10)-三烯-3,17-二醇, ICI 182,780, ZD 182780, ZD 9238, ZM 182780, 与法洛德
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关于此项目
经验公式（希尔记法）:
C32H47F5O3S
化学文摘社编号:
分子量:
606.77
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Assay:
>98%
产品名称
氟维司群, Vetec™, reagent grade, >98%
InChI
1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1
SMILES string
[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)Cc4cc(O)ccc24
InChI key
VWUXBMIQPBEWFH-WCCTWKNTSA-N
grade
reagent grade
product line
Vetec™
assay
>98%
storage temp.
2-8°C
Gene Information
human ... ESR1(2099), ESR2(2100)
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Biochem/physiol Actions
氟维司群是一种选择性雌激素受体下调剂（SERD）；具有高亲和力的雌激素受体拮抗剂。
氟维司群（ICI 182,780）是一种选择性雌激素受体下调剂（SERD）。氟维司群是一种具有高亲和力的雌激素受体拮抗剂。IC50 = 0.29 nM。氟维司群是第一种“纯”抗雌激素，在体外和体内均无激动活性。
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
监管及禁止进口产品
此项目有
Meng-Yuan Li et al.
Cells, 13(3) (2024-02-09)
(1) Background: Inflammatory responses are implicated in embryo implantation, decidualization, pregnancy maintenance and labor. Both embryo implantation and decidualization are essential to successful pregnancy in rodents and primates. S100A6 is involved in inflammation, tumor development, apoptosis and calcium homeostasis. S100A6
Haimei Li et al.
Life sciences, 344, 122581-122581 (2024-03-22)
Hypocretin is synthesized exclusively in the hypothalamus and distributes inputs to several areas of the brain, which may play an important role in depression. Our previous study showed that hypocretin-1 was increased in the lateral hypothalamus in female patients with
Jieyu He et al.
Aging medicine (Milton (N.S.W)), 6(4), 379-385 (2024-01-19)
To investigate the relationship between icariin and the osteoblastic differentiation of vascular smooth muscle cells (VSMCs) and the signal pathway involved. We applied a universally accepted calcification model of VSMCs induced by β glycerophosphate. Then the VSMCs calcification was observed
Yuet-Kin Leung et al.
PloS one, 9(5), e98037-e98037 (2014-05-20)
Fulvestrant (ICI-182,780) has recently been shown to effectively suppress prostate cancer cell growth in vitro and in vivo. But it is unclear whether microRNAs play a role in regulating oncogene expression in fulvestrant-treated prostate cancer. Here, this study reports hsa-miR-765
Chenyang Huang et al.
Cell death discovery, 4, 23-23 (2018-08-16)
Recurrent implantation failure (RIF) caused by various etiological factors remains a challenge for fertility clinicians using assisted reproductive technology (ART) worldwide. Dysregulation of leukemia inhibitory factor (LIF) in the endometria of women with RIF is involved in impaired endometrial receptivity
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