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Anthony R Temple et al.
Clinical therapeutics, 35(9), 1361-1375 (2013-08-27)
A standardized approach to dosing acetaminophen in pediatric populations was published in 1983. That review proposed specific weight-related dosing for infants and children weighing 6 through 95 lb and an age-based schedule for children aged <4 months through 11 years.
Jun-Won Yun et al.
Toxicology letters, 229(1), 59-65 (2014-06-10)
Drug-induced hepatotoxicity is a serious adverse effect with high morbidity and mortality rates but substantial individual to individual variation is observed in its severity. Here we sought to discover factors determining the susceptibility to acetaminophen (APAP)-induced hepatotoxicity by comparing the
Kenji Takemoto et al.
FEBS open bio, 4, 777-787 (2014-10-29)
Excessive acetaminophen (APAP) use is one of the most common causes of acute liver failure. Various types of cell death in the damaged liver are linked to APAP-induced hepatotoxicity, and, of these, necrotic cell death of hepatocytes has been shown
Tongya Yu et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(10), 861-867 (2014-05-02)
1. In this article, the modulatory effects of extracts from vinegar-baked Radix Bupleuri (VBRB) and saikosaponins on the activity of CYP1A2, CYP2C9 and CYP3A4 were investigated in vitro. 2. Microsomal in vitro incubation method was utilized to simulate metabolic reaction
Niraj S Trasi et al.
The journal of physical chemistry. B, 118(33), 9974-9982 (2014-07-31)
Amorphous forms of drugs are increasingly being used to deliver poorly water-soluble compounds. Therefore, understanding the magnitude and origin of differences in crystallization kinetics is highly important. The goal of this study was to better understand the factors that influence
Frederic T Billings et al.
PloS one, 10(2), e0117625-e0117625 (2015-02-24)
Cardiopulmonary bypass (CPB) lyses erythrocytes and induces lipid peroxidation, indicated by increasing plasma concentrations of free hemoglobin, F2-isoprostanes, and isofurans. Acetaminophen attenuates hemeprotein-mediated lipid peroxidation, reduces plasma and urine concentrations of F2-isoprostanes, and preserves kidney function in an animal model
Laura Asturias-Arribas et al.
Analytica chimica acta, 834, 30-36 (2014-06-15)
This paper describes the voltammetric determination of cocaine in presence of three different interferences that could be found in street samples using disposable sensors. The electrochemical analysis of this alkaloid can be affected by the presence of codeine, paracetamol or
Astrid Jordet Langhammer et al.
Phytotherapy research : PTR, 28(10), 1573-1576 (2014-01-25)
In addition to CYP2E1, several CYP isoenzymes, notably CYP1A2, 2D6, and 3A4, are suggested to contribute in acetaminophen oxidation and formation of the hepatotoxic metabolite N-acetyl-p-benzoquinone imine (NAPQI). The in vitro CYP2E1 inhibitory potentials of fennel and raspberry leaf, herbs
Raveendhara R Bannuru et al.
Annals of internal medicine, 162(1), 46-54 (2015-01-07)
The relative efficacy of available treatments of knee osteoarthritis (OA) must be determined for rational treatment algorithms to be formulated. To examine the efficacy of treatments of primary knee OA using a network meta-analysis design, which estimates relative effects of
Hiroshi Kataoka et al.
PloS one, 9(8), e104741-e104741 (2014-08-16)
When cells die by necrosis in vivo they stimulate an inflammatory response. It is thought that this response is triggered when the injured cells expose proinflammatory molecules, collectively referred to as damage associated molecular patterns (DAMPs), which are recognized by
H-J Tsai et al.
Diabetic medicine : a journal of the British Diabetic Association, 32(3), 382-390 (2014-10-15)
To investigate the temporal relationship between non-steroidal anti-inflammatory drug use and the development of chronic kidney disease in people with Type 2 diabetes mellitus. We conducted a retrospective cohort study and followed up a population with Type 2 diabetes who
Daniel Rodrigo-Torres et al.
Hepatology (Baltimore, Md.), 60(4), 1367-1377 (2014-04-05)
Severe liver diseases are characterized by expansion of liver progenitor cells (LPC), which correlates with disease severity. However, the origin and role of LPC in liver physiology and in hepatic injury remains a contentious topic. We found that ductular reaction
Musen Lin et al.
Journal of pharmacological sciences, 127(2), 203-210 (2015-03-03)
Acetaminophen (APAP) is used drugs worldwide for treating pain and fever. However, APAP overdose is the principal cause of acute liver failure in Western countries. Salvianolic acid B (SalB), a major water-soluble compound extracted from Radix Salvia miltiorrhiza, has well-known
Mike De Vrieze et al.
Analytical and bioanalytical chemistry, 406(25), 6179-6188 (2014-08-16)
Over the past decades, several in vitro methods have been tested for their ability to predict drug penetration across the blood-brain barrier. So far, in high-performance liquid chromatography, most attention has been paid to micellar liquid chromatography and immobilized artificial
Milena Mennecozzi et al.
PloS one, 10(4), e0122786-e0122786 (2015-04-08)
There is increasing amount of evidence for sex variation in drug efficiency and toxicity profiles. Women are more susceptible than men to acute liver injury from xenobiotics. In general, this is attributed to sex differences at a physiological level as
Extended-release oxycodone and acetaminophen (Xartemis XR).
The Medical letter on drugs and therapeutics, 56(1447), 59-60 (2014-07-22)
Timothy D Heden et al.
Journal of applied physiology (Bethesda, Md. : 1985), 118(5), 624-634 (2014-12-30)
Abnormally elevated postprandial glucose and triacylglycerol (TAG) concentrations are risk factors for cardiovascular disease in type 2 diabetes. The most effective time to exercise to lower postprandial glucose and TAG concentrations is unknown. Thus the aim of this study was
Jeffrey J Sutherland et al.
PloS one, 10(3), e0118991-e0118991 (2015-03-05)
Pharmaceutical prescribing and drug-drug interaction data underlie recommendations on drug combinations that should be avoided or closely monitored by prescribers. Because the number of patients taking multiple medications is increasing, a comprehensive view of prescribing patterns in patients is important
Deadly pain pills: everyday, 46 people in the U.S. die from legal pain pills. Here's how to avoid being a statistic.
Consumer reports, 79(9), 19-22 (2014-08-13)
Yu Yamaura et al.
Toxicology, 322, 89-98 (2014-05-28)
MicroRNAs (miRNAs) in body fluids have received attention as potential biomarkers of organ damage because miRNAs that are highly or specifically expressed in a given organ are likely released into body fluids as a result of damage to that organ.
Arne Trettin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 964, 172-179 (2014-02-11)
Oleic acid (cis-9,10-octadecenoic acid) is the most abundant monounsaturated fatty acid in human blood. Peroxynitrite (ONOO(-)) is a short-lived species formed from the reaction of nitric oxide (NO) and superoxide (O2(-)). Peroxynitrite is a potent oxidizing and moderate nitrating agent.
Alexandre Grand-Guillaume Perrenoud et al.
Journal of chromatography. A, 1360, 275-287 (2014-08-19)
Superficially porous particles (SPP), or core shell particles, which consist of a non-porous silica core surrounded by a thin shell of porous silica, have gained popularity as a solid support for chromatography over the last decade. In the present study
Yuchao Xie et al.
Toxicology and applied pharmacology, 279(3), 266-274 (2014-06-07)
Acetaminophen (APAP) overdose is the most prevalent cause of drug-induced liver injury in western countries. Numerous studies have been conducted to investigate the mechanisms of injury after APAP overdose in various animal models; however, the importance of these mechanisms for
J Rajanayagam et al.
Archives of disease in childhood, 100(1), 77-80 (2014-09-18)
In children, paracetamol overdose due to deliberate self-poisoning, accidental exposure or medication errors can lead to paediatric acute liver failure and death. In Australia and New Zealand, the nature of ingestion and outcomes of paracetamol-associated paediatric acute liver failure have
A A Defresne et al.
British journal of anaesthesia, 113(3), 501-507 (2014-05-17)
Intraoperative recruitment manoeuvres (RMs) combined with PEEP reverse the decrease in functional residual capacity (FRC) associated with anaesthesia and improve intraoperative oxygenation. Whether these benefits persist after operation remains unknown. We tested the hypothesis that intraoperative RMs associated with PEEP
Yuping Jing et al.
PloS one, 10(4), e0122781-e0122781 (2015-04-18)
Aminotriazole (ATZ) is commonly used as a catalase (CAT) inhibitor. We previously found ATZ attenuated oxidative liver injury, but the underlying mechanisms remain unknown. Acetaminophen (APAP) overdose frequently induces life-threatening oxidative hepatitis. In the present study, the potential hepatoprotective effects
Deepika Thakur et al.
Clinical therapeutics, 37(1), 212-224 (2015-01-17)
The objective of this systematic review was to assess the clinical efficacy, safety, tolerability, and health-related quality of life outcomes associated with management of moderate-to-severe chronic pain with oxycodone/naloxone and tapentadol, focusing on the effect of these treatments on patients'
Katarzyna Wawrzyniak et al.
International forum of allergy & rhinology, 4(7), 542-547 (2014-03-05)
Inadequate surgical field visualization due to intraoperative bleeding during endoscopic sinus surgery (ESS) can cause major complications. The aim of this prospective study was to compare the effect of preoperative administration of clonidine and melatonin on the quality of the
Eunkyung Lee et al.
Journal of hazardous materials, 276, 1-9 (2014-05-28)
Overall photodegradation of pharmaceuticals, personal care products (PPCPs) and pharmaceutical metabolites were investigated in order to evaluate their photochemical fate in aquatic environments in various natural organic matter (NOM) enriched solutions. Tested PPCPs exhibited different rates of loss during direct
Charalambos Gustav Antoniades et al.
Hepatology (Baltimore, Md.), 59(4), 1564-1576 (2013-11-28)
Acetaminophen-induced acute liver failure (AALF) is characterized both by activation of innate immune responses and susceptibility to sepsis. Circulating monocytes and hepatic macrophages are central mediators of inflammatory responses and tissue repair processes during human AALF. Secretory leukocyte protease inhibitor
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