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John Fr Robertson et al.
The Lancet. Oncology, 14(3), 228-235 (2013-02-19)
Insulin-like growth factors (IGF-1 and IGF-2) bind to the IGF-1 receptor (IGF-1R), increasing cell proliferation and survival. Ganitumab is a monoclonal IgG1 antibody that blocks IGF-1R. We tested the efficacy and safety of adding ganitumab to endocrine treatment for patients
Won Joon Seong et al.
Archives of gynecology and obstetrics, 281(5), 907-912 (2009-10-22)
To evaluate cord blood amino-terminal pro-brain natriuretic peptide (NT-proBNP) levels according to the mode of delivery. Between 1 March and 31 May 2007, 106 blood samples were drawn from the umbilical vein at the time of delivery. Eighty-four NT-proBNP levels
Naoki Tamasawa et al.
Diabetes research and clinical practice, 72(1), 6-11 (2005-11-01)
Elevations in plasma triglyceride (TG) and free fatty acid (FFA) concentrations are generally thought to play a role in the pathogenesis of insulin-resistant diabetes. The objective of this study was to investigate the relationship between hypertriglyceridemia and glucose-stimulated insulin responsiveness
Bradford B Smith et al.
Anesthesia and analgesia, 128(4), 621-628 (2018-09-01)
Noncardiac surgery (NCS) following percutaneous coronary intervention (PCI) with stenting is sometimes associated with major adverse cardiac events (MACEs). Second-generation drug-eluting stents (DES) were developed to decrease the incidence of MACE seen with bare metal and first-generation DES. The medical
J-E Eom et al.
Vox sanguinis, 107(2), 181-187 (2014-02-13)
Transplantation of cryopreserved umbilical cord blood (UCB) can be used to treat a multitude of haematologic and immunological diseases. In this study, we examined the quality of UCB cryopreserved for 2 (group I), 4 (group II) and 6 (group III)
L L Southern et al.
Journal of animal science, 67(3), 628-634 (1989-03-01)
An experiment was conducted with 96 weanling pigs (avg initial wt 18.5 kg) divided into six treatment with two replicates of eight pigs each. Pigs in Treatments 1, 2 and 3 were penned in outside pens with dirt lots that
Henry L Keen et al.
Physiological genomics, 18(1), 33-42 (2004-04-01)
Diminished activity of peroxisome proliferator-activated receptor-gamma (PPARgamma) may play a role in the pathogenesis of hypertension and vascular dysfunction. To better understand what genes are regulated by PPARgamma, an experimental data set was generated by microarray analysis, in duplicate, of
Simona Nistorescu et al.
Nanomaterials (Basel, Switzerland), 13(1) (2023-01-09)
Nowadays, using polymers with specific characteristics to coat the surface of a device to prevent undesired biological responses can represent an optimal strategy for developing new and more efficient implants for biomedical applications. Among them, zwitterionic phosphorylcholine-based polymers are of
C Yang et al.
British journal of haematology, 105(2), 478-485 (1999-05-08)
It has been suggested that circulating levels of thrombopoietin (TPO) are determined primarily by platelet and megakaryocyte clearance of TPO and not by changes in hepatic TPO production. The experimental evidence accumulated so far to support this hypothesis is incomplete.
Lydie Prat-Larquemin et al.
Obesity research, 12(3), 556-561 (2004-03-27)
To investigate AGT secretion in cultured adipocytes from obese patients and its relationship with obesity-related phenotypes, blood pressure, and the M235T polymorphism in the AGT gene. Measurements, including anthropometry, body composition (DXA), and blood pressure, were performed in 61 overweight
Ramon Diaz-Arrastia et al.
Archives of neurology, 60(6), 818-822 (2003-06-18)
Late posttraumatic seizures are a common complication of moderate and severe traumatic brain injury. Inheritance of the apolipoprotein E (APOE) epsilon4 allele is associated with increased risk of Alzheimer disease, progression to disability in multiple sclerosis, and poor outcome after
Ales Zák et al.
The Journal of nutritional biochemistry, 19(9), 634-641 (2008-02-19)
The aim of this study was to investigate the effect of the microsomal triglyceride transfer protein (MTP) -493G/T polymorphism on clinical and biochemical parameters in relation to the presence of metabolic syndrome (MS). A group of 270 participants, 143 men
Natan D da Silva et al.
Genes, 14(1) (2023-01-22)
Patients with peripheral artery disease (PAD) have reduced muscle capillary density. Walking training (WT) is recommended for PAD patients. The goal of the study was to verify whether WT promotes angiogenesis in PAD-affected muscle and to investigate the possible role
Andreia Bufalino et al.
Birth defects research. Part A, Clinical and molecular teratology, 88(11), 980-986 (2010-10-05)
Polymorphisms in genes that are involved in folic acid metabolism may be important maternal risk factors for the birth of a child with nonsyndromic cleft lip and/or palate (NSCL/P). The aim of this study was to determine the involvement of
Edmondo Falleti et al.
Hepatology (Baltimore, Md.), 56(5), 1641-1650 (2012-05-23)
Vitamin D deficiency seems to predict the unsuccessful achievement of sustained viral response (SVR) after antiviral treatment in hepatitis C virus (HCV) difficult-to-treat genotypes. Vitamin D binding protein (GC) gene polymorphisms are known to influence vitamin D levels. This study
Jian Wang et al.
Zhonghua wai ke za zhi [Chinese journal of surgery], 48(12), 919-923 (2010-11-09)
To research the effects of bile acids on the expression of interleukin-6 (IL-6) and the cell viability in QBC939 cell line. Human cholangiocarcinoma cells were stimulated with 800 µmol/L bile acid (CA), 100 µmol/L deoxycholate (DCA), 100 µmol/L chenodeoxycholic acid
E B Taylor et al.
American journal of physiology. Endocrinology and metabolism, 287(6), E1082-E1089 (2004-08-05)
LKB1 complexed with MO25 and STRAD has been identified as an AMP-activated protein kinase kinase (AMPKK). We measured relative LKB1 protein abundance and AMPKK activity in liver (LV), heart (HT), soleus (SO), red quadriceps (RQ), and white quadriceps (WQ) from
R A Maitland et al.
Diabetic medicine : a journal of the British Diabetic Association, 31(8), 963-970 (2014-05-07)
To examine the prediction of gestational diabetes in obese women using routine clinical measures and measurement of biomarkers related to insulin resistance in the early second trimester. A total of 117 obese pregnant women participating in a pilot trial of
Eiichi Sasaki et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 20(2), 208-214 (2006-12-29)
Previously, we used the reverse transcription-polymerase chain reaction (RT-PCR) to show that mammaglobin (MGB1) can serve as a differential marker of breast cancer metastasis from primary lung cancer. However, mRNA-based methods are not appropriate for use in clinical practices. In
Experimental and ab initio study of the HO2.CH3OH complex: thermodynamics and kinetics of formation.
Lance E Christensen et al.
The journal of physical chemistry. A, 110(21), 6948-6959 (2006-05-26)
Near-infrared spectroscopy was used to monitor HO2 formed by pulsed laser photolysis of Cl2-O2-CH3OH-N2 mixtures. On the microsecond time scale, [HO2] exhibited a time dependence consistent with a mechanism in which [HO2] approached equilibrium via HO2 + HO2.CH3OH (3, -3).
Fabrice André et al.
The Lancet. Oncology, 15(6), 580-591 (2014-04-20)
Disease progression in patients with HER2-positive breast cancer receiving trastuzumab might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. We aimed to assess whether the addition of the mTOR inhibitor everolimus to trastuzumab might restore sensitivity to trastuzumab.
Jan Claassen et al.
Epilepsia, 43(2), 146-153 (2002-03-21)
New continuous infusion antiepileptic drugs (cIV-AEDs) offer alternatives to pentobarbital for the treatment of refractory status epilepticus (RSE). However, no prospective randomized studies have evaluated the treatment of RSE. This systematic review compares the efficacy of midazolam (MDL), propofol (PRO)
Dane Salazar et al.
Clinical orthopaedics and related research, 472(7), 2269-2275 (2014-04-09)
Heterotopic ossification is the most common extrinsic cause of elbow contracture and may lead to clinically important stiffness, and rarely, complete bony ankylosis. Surgery sometimes is performed to treat this problem, and published reports differ regarding the factors that are
Ira M Jacobson et al.
Lancet (London, England), 384(9941), 403-413 (2014-06-08)
Although the addition of the HCV NS3/4A protease inhibitors boceprevir and telaprevir to pegylated interferon (peginterferon) alfa plus ribavirin has improved sustained virological response (SVR) in treatment-naive and treatment-experienced patients infected with hepatitis C virus (HCV) genotype 1, the regimens
Niels Wcj van de Donk et al.
The Lancet. Haematology, 5(10), e479-e492 (2018-10-07)
In patients with recently diagnosed multiple myeloma, the HOVON-50 phase 3 trial showed improved event-free survival for thalidomide-containing induction and maintenance regimens (in conjunction with high-dose melphalan and autologous stem cell transplantation [auto-SCT]) after a median of 52 months of
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