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108-95-2
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关键词:'108-95-2'
显示 1-30 共 124 条结果 关于 "108-95-2" 范围 论文
Ling-Ping Lai et al.
American heart journal, 144(3), 485-490 (2002-09-14)
Human minK protein is the beta-subunit of I(Ks) potassium channel and plays an important role in cardiac cellular electrophysiology. We investigated the association between human atrial fibrillation and the polymorphism of minK gene (38G or 38S) with a case-control study.
Steven S Yu et al.
Clinical genitourinary cancer, 15(6), 742-749 (2017-07-03)
AEZS-108 (zoptarelin doxorubicin) is a cytotoxic hybrid molecule consisting of doxorubicin covalently coupled with a luteinizing hormone-releasing hormone (LHRH) analogue, which selectively targets doxorubicin to tumor cells expressing LHRH receptors. We report the clinical efficacy of AEZS-108 in a phase
C C Liu et al.
Lupus, 20(2), 131-136 (2010-11-17)
To investigate the associations of DNA methylation levels and mRNA expressions of DNA cytosine-5-methyltransferase 1 (DNMT1) and methyl CpG-binding domain 2 (MBD2) with systemic lupus erythematosus (SLE), 108 patients with SLE and 97 healthy controls were enrolled in this study.
Maki Ando et al.
Japanese journal of cancer research : Gann, 93(5), 591-597 (2002-05-31)
Irinotecan often causes unpredictably severe, occasionally fatal, toxicity involving leukopenia or diarrhea. It is converted by carboxyesterase to an active metabolite, SN-38, which is further conjugated and detoxified to SN-38-glucuronide by UDP-glucuronosyltransferase (UGT). We genotyped the UGT1A7 gene by direct
Maya A Kappil et al.
Epigenetics, 10(9), 842-849 (2015-07-18)
The importance of imprinted genes in regulating feto-placental development has been long established. However, a comprehensive assessment of the role of placental imprinted gene expression on fetal growth has yet to be conducted. In this study, we examined the association
Lu-lu Zhang et al.
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 32(3), 168-172 (2011-05-04)
To investigate the potential association between factor VIII inhibitor development and polymorphisms of tumor necrosis factor-α (TNF-α)-308 and cytotoxic T-lymphocyte associated protein-4 gene in Chinese Han patients with hemophilia A (HA). The single base change polymorphism in TNF-α and CTLA-4
Chan-Soon Park et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 144(1), 96-100 (2011-04-16)
To investigate the role of single-nucleotide polymorphisms (SNPs) in the gene encoding Toll-like receptor (TLR) 2 in Korean patients with chronic rhinosinusitis (CRS) and controls. A case-control study. Subjects (N = 214) were all adults (>20 years old) and were
Zhen Kun Yang et al.
International journal of cardiology, 197, 241-247 (2015-07-06)
Glycated albumin (GA) and the endogenous secretory receptor for advanced glycation endproducts (esRAGE) may modulate risk related to atherosclerosis. We tested the hypothesis that elevated GA and reduced esRAGE in serum are associated with adverse clinical outcomes in patients with
R Muñiz-Mendoza et al.
Genetics and molecular research : GMR, 11(3), 2315-2320 (2012-07-31)
DNA repair proteins maintain DNA integrity; polymorphisms in genes coding for these proteins can increase susceptibility to colorectal cancer (CRC) development. We analyzed a possible association of MLH1 -93G>A and 655A>G and XRCC1 Arg194Trp and Arg399Gln polymorphisms with CRC in
Louise Kuhn et al.
The American journal of clinical nutrition, 84(3), 610-615 (2006-09-09)
Mannose-binding lectin (MBL-2) allele variants are associated with deficiencies in innate immunity and have been found to be correlated with HIV infection in adults and children. We tested whether MBL-2 variants among infants born to HIV-positive mothers have an increased
Thomas K Kilvaer et al.
Journal of translational medicine, 9, 104-104 (2011-07-08)
Non-gastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) constitute a heterogeneous group of tumors with poor prognosis. Fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor-1 (FGFR-1), in close interplay with platelet-derived growth factor-B (PDGF-B) and vascular endothelial growth factor
J K Wolford et al.
Diabetic medicine : a journal of the British Diabetic Association, 23(4), 367-376 (2006-04-20)
The aldose reductase gene (AKR1B1) is a strong candidate for diabetic nephropathy, and the T allele at rs759853 and the Z-2 allele at an [AC]n microsatellite are associated with diabetic kidney disease in some populations. As AKR1B1 is located on
B Knebel et al.
Deutsche medizinische Wochenschrift (1946), 134(20), 1040-1046 (2009-05-08)
Apart from impaired reproductive function patients with polycystic ovary syndrome (PCOS) also have signs and symptoms belonging to the metabolic syndrome. A genetic basis for PCOS is likely as the syndrome clusters in families. Putative candidate genes are paraoxonase (PON)-1
Marloes D M Romijn et al.
International journal of geriatric psychiatry, 30(7), 758-765 (2014-11-05)
In dialysis-dependent and severe chronic kidney disease (CKD) patients, cognitive impairment is found in 16-29%. In community-dwelling population without dementia mixed results have been observed. We investigated the relationship between renal function and cognition in patients from a memory clinic.
Annikka Kalliokoski et al.
British journal of clinical pharmacology, 66(6), 818-825 (2008-10-01)
To establish whether the effect of SLCO1B1[encoding organic anion transporting polypeptide 1B1 (OATP1B1)] c.521T-->C (p.Val174Ala) polymorphism on the pharmacokinetics of repaglinide is dose-dependent. Twelve healthy volunteers with the SLCO1B1 c.521TT genotype (controls) and eight with the c.521CC genotype ingested a
Purnima P Desai et al.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 116B(1), 98-101 (2002-12-24)
Apolipoprotein D (APOD, gene; apoD, protein) is involved in neuroregenerative and neurodegenerative processes, and is upregulated in late-onset Alzheimer disease (AD) patients compared to nondemented controls. No genetic association studies have yet been carried out to investigate the role of
Brett L Cucchiara et al.
Stroke, 40(7), 2332-2336 (2009-05-23)
Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a marker of unstable atherosclerotic plaque, and is predictive of both primary and secondary stroke in population-based studies. We conducted a prospective study of patients with acute TIA who presented to the ED. Clinical risk
Min-Young Chun et al.
The Journal of clinical endocrinology and metabolism, 95(7), 3547-3551 (2010-05-07)
Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor, and its polymorphisms are associated with proliferative diabetic retinopathy (PDR) and macular edema. We investigated the contributions of VEGF gene polymorphisms to nonproliferative diabetic retinopathy (NPDR) as
Katri Köninki et al.
Breast cancer research : BCR, 11(3), R37-R37 (2009-06-23)
Classification of breast cancers according to the HER-2 oncogene status is of central importance in the selection of post-surgical therapies. A decrease in the proportion of HER-2-positive breast cancer has been suspected, but no data on the incidence trends at
Tânia B Ferraz et al.
Diabetes research and clinical practice, 78(1), 23-29 (2007-04-24)
C-reactive protein (CRP), an inflammatory biomarker, has been associated with the development of diabetes. Gestational diabetes (GDM) predicts type 2 diabetes (T2DM) and may be part of the metabolic syndrome (MS). Few studies have examined the association of CRP, MS
Virginia Sánchez Monroy et al.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 62(3), 632-634 (2014-01-23)
Hepatocyte nuclear factor 4α (HNF4A) is a transcription factor that regulates the expression of genes in the liver, pancreas, kidney, intestine, and other tissues. Previous studies in the Mexican population have shown a high frequency of the Thr130Ile polymorphism and
Shiguo Liu et al.
Neuroscience letters, 495(2), 155-158 (2011-03-30)
An earlier study indicated a possible relationship between Tourette syndrome (TS) and the cytokines. To explore this further, we analyzed the association of the polymorphisms, IL8 -251A/T, IL12B -1188A/C and TNF-α -238A/G, in the IL8, IL12B and TNF-α cytokine genes
Hai-shan Li et al.
Wei sheng yan jiu = Journal of hygiene research, 35(2), 149-151 (2006-06-09)
Investigate the genetic polymorphisms of aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH), major enzymes involving the trichloroethylene (TCE) metabolism, associated with susceptibility to TCE-induced medicamentosa-like dermatitis. The study included 108 patients with TCE-induced medicamentosa-like dermatitis and 145 healthy controls exposed
Ulla Wilking et al.
Breast cancer research and treatment, 125(2), 553-561 (2010-07-16)
This retrospective study investigates the correlation of intra-individual HER2 status between primary breast cancers and corresponding recurrences in a population derived cohort. The REMARK criteria were used as reference. In 151 breast cancer patients, primary tumors were analyzed for HER2
Hui Chen et al.
Analytical chemistry, 84(20), 8871-8879 (2012-10-09)
The ultraweak chemiluminescence (CL) from the reaction of hydrogen peroxide and carbonate is strongly enhanced by the branched NaYF(4):Yb(3+)/Er(3+) nanoparticle (NP) in the presence of aqueous ammonia. It was explained that ammonia catalyzes the decomposition of peroxymonocarbonate, which is the
Su Hyung Hong et al.
Journal of preventive medicine and public health = Yebang Uihakhoe chi, 39(2), 135-140 (2006-04-18)
Polymorphisms of genes from glutathione S-transferases (GSTs) and N-acetyltransferase 2 (NAT2) have been associated with increased susceptibility to various cancers. Previous results showed that East Asians such as Koreans, Japanese and Chinese have a much higher frequency of the GSTM1
Kadriye Altok Reis et al.
Renal failure, 33(5), 469-474 (2011-04-20)
Diabetic nephropathy (DN) is a leading cause of diabetes-related morbidity and mortality. The aim of this study was to evaluate the relationship of AGT M235T and apoprotein E (APO E) gene polymorphism with DN in Turkish patients of Type 2
Jimmy Belotte et al.
PloS one, 10(8), e0135739-e0135739 (2015-08-25)
Ovarian cancer is the deadliest of all gynecologic cancers. Recent evidence demonstrates an association between enzymatic activity altering single nucleotide polymorphisms (SNP) with human cancer susceptibility. We sought to evaluate the association of SNPs in key oxidant and antioxidant enzymes
Rodrig Marculescu et al.
Diabetes, 51(12), 3582-3585 (2002-11-28)
Recently, inflammation has received considerable attention in the pathogenesis of both type 2 diabetes and atherosclerosis. The interleukin-1 receptor antagonist (IL-1ra) is a major modulator of the interleukin-1 pro-inflammatory pathway. We studied the relationship between a variable number tandem repeat
Masatsugu Ueda et al.
Human cell, 22(2), 49-54 (2009-04-22)
A functional T to G germline polymorphism in the promoter region of murine double-minute 2 homolog single nucleotide polymorphism 309 (MDM2-SNP309) has been reported to profoundly accelerate tumor formation, suggesting that it may also represent a powerful cancer predisposing allele.
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