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124-48-1
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关键词:'124-48-1'
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Robert S Kiss et al.
Arteriosclerosis, thrombosis, and vascular biology, 27(5), 1139-1145 (2007-02-17)
We have used a multitiered approach to identify genetic and cellular contributors to high-density lipoprotein (HDL) deficiency in 124 human subjects. We resequenced 4 candidate genes for HDL regulation and identified several functional nonsynonymous mutations including 2 in apolipoprotein A-I
Yibo Wu et al.
PloS one, 10(8), e0136671-e0136671 (2015-08-28)
MicroRNAs (miRNAs) are a class of short non-coding RNA molecules, which diversely regulate gene expression in organisms. Although the regulatory role of these small RNA molecules has been recently explored in animal spermatogenesis, the role of miR-124 in male germ
Neal Luther et al.
Neuro-oncology, 16(6), 800-806 (2014-02-15)
Reasons for failure in prior human glioma convection-enhanced delivery (CED) clinical trials remain unclear. Concentration-dependent volume of distribution (Vd) measurement of CED-infused agents in the human brain is challenging and highlights a potential technical shortcoming. Activity of iodine isotope 124
Sebastian J C M M Neggers et al.
European journal of endocrinology, 173(3), 313-323 (2015-06-07)
To evaluate extended dosing intervals (EDIs) with lanreotide Autogel 120 mg in patients with acromegaly previously biochemically controlled with octreotide LAR 10 or 20 mg. Patients with acromegaly had received octreotide LAR 10 or 20 mg/4 weeks for ≥ 6
Maxim A Moroz et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 48(5), 827-836 (2007-05-04)
The norepinephrine transporter (NET) has recently been suggested as a useful reporter gene. We have extended this effort by constructing an internal ribosomal entry site (IRES)-linked hNET-green fluorescent protein (GFP) hybrid reporter gene for both nuclear and optical imaging. A
S Regnér et al.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 8(6), 600-607 (2008-10-14)
The pathophysiology of acute pancreatitis (AP) may be studied using markers of protease activation (active carboxypeptidase B (aCAP), the activation peptide of carboxypeptidase B (CAPAP)), leakage of pancreatic enzymes (trypsinogen-2, procarboxypeptidase B (proCAP), amylase), and inflammation (monocyte chemoattractant protein-1 (MCP-1)
Jung-Woo Choi et al.
Human pathology, 44(7), 1375-1381 (2013-02-06)
Activated B-cell-like subtype of diffuse large B-cell lymphoma (DLBCL) is characterized by chronic active B-cell receptor signaling and a constitutive activation of the nuclear factor κB pathway. As a driving force of nuclear factor κB overactivity, myeloid differentiation primary response
Ruizhuo Ning et al.
Oncotarget, 8(56), 95481-95494 (2017-12-10)
D-4F is an apolipoprotein-A1 mimetic peptide that promotes anti-inflammatory effects. MicroRNA-124 is the most abundant brain-specific microRNA and has anti-inflammatory effects. In this study, we investigated the therapeutic efficacy and mechanisms of D-4F treatment of stroke in type one diabetes
P Prusis et al.
Journal of molecular graphics & modelling, 15(5), 307-317 (1998-06-26)
A model is presented of the melanocortin 1 receptor (MC1R), constructed by use of an unbiased, objective method. The model is created directly from data derived from multiple sequence analysis, a low-resolution EM-projection map of rhodopsin, and the approximate membrane
A Ernst et al.
Peptides, 27(7), 1787-1793 (2006-03-08)
Proneurotensin/neuromedin N (pro NT/NMN) is the common precursor of two biologically active peptides, neurotensin (NT) and neuromedin N (NMN). We have established antibodies against peptide sequences of the NT/NMN precursor and developed a sandwich immunoassay for the detection of pro
C H Park et al.
Biochemistry, 25(14), 3977-3982 (1986-07-15)
The three-dimensional structure of bovine prothrombin fragment 1 has been solved at 2.8-A resolution. The electron density clearly reveals four disulfide bridges along with more than 80% of the side chains completely in density, which correspond faithfully to the kringle
Hydrodechlorination of dichlorobiphenyls over Ni-Mo/Al2O3 catalysts prepared by spray-drying method.
G Gryglewicz et al.
Chemosphere, 62(1), 135-141 (2005-06-14)
The hydrodechlorination (HDCl) process of 2,3-, 2,4- and 2,5-dichlorobiphenyls was studied over a sulphided Ni-Mo/Al(2)O(3) catalyst in a stirred autoclave at a hydrogen pressure of 3 MPa. The catalysts were prepared by spray-drying. They were characterized by N(2) adsorption, thermogravimetry
Keiko Sato et al.
Microbiology (Reading, England), 155(Pt 4), 1282-1293 (2009-04-01)
The periodontopathic bacterium Porphyromonas gingivalis forms pigmented colonies when incubated on blood agar plates as a result of accumulation of mu-oxo haem dimer on the cell surface. Gingipain-adhesin complexes are responsible for production of mu-oxo haem dimer from haemoglobin. Non-pigmented
G Campanholle et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 59(10), 861-869 (2010-04-17)
Ischemia and reperfusion injury (IRI) are mainly caused by leukocyte activation, endothelial dysfunction and production of reactive oxygen species. Moreover, IRI can lead to a systemic response affecting distant organs, such as the lungs. The objective was to study the
S Darb-Esfahani et al.
Virchows Archiv : an international journal of pathology, 461(2), 109-116 (2012-07-04)
Ovarian high-grade serous carcinoma (HGSC, type 2 ovarian carcinoma) is a poor prognosis cancer with limited therapeutic options. We aimed to investigate the expression pattern and prognostic potential of the metastasis-promoting protein anterior gradient 2 (AGR2) in primary HGSC. Immunohistochemistry
Kanenobu Ijuin et al.
Mechanisms of development, 125(5-6), 462-474 (2008-02-27)
We examined the roles of Notch signaling and fibroblast growth factors (FGFs) in the gliogenesis of mouse mesencephalic neural crest cells. The present study demonstrated that Notch activation or FGF treatment promotes the differentiation of glia expressing glial fibrillary acidic
Julia Kirchheiner et al.
Pharmacogenetics, 12(7), 571-580 (2002-10-03)
In-vitro data indicated a contribution of cytochrome P450 enzymes 1A2, 3A4, 2C9, 2C19 and 2D6 to biotransformation of doxepin. We studied the effects of genetic polymorphisms in CYP2D6, CYP2C9 and CYP2C19 on E- and Z-doxepin pharmacokinetics in humans. Doxepin kinetics
Bhavana Bhatnagar et al.
Annals of hematology, 93(4), 653-660 (2013-10-08)
We retrospectively evaluated the tolerability and efficacy of fractionated total body irradiation (TBI) (1,200 cGy) and melphalan (MEL) (100-110 mg/m(2)) myeloablative conditioning in 48 patients with nonremission AML (n = 14), ALL (n = 10), NHL (n = 18), and other refractory hematologic malignancies (n = 6) who
M K Balasubramanian et al.
The EMBO journal, 15(23), 6426-6437 (1996-12-02)
Profilins bind to monomeric actin and also interact with ligands such as phosphoinositide 4,5-bisphosphate, the proline-rich protein VASP and a complex of four to six polypeptides identified in Acanthamoeba that includes two actin-related proteins. Here, we report the identification and
I Y Lee et al.
The Journal of biological chemistry, 255(13), 6121-6127 (1980-07-10)
Human serum albumin (HSA) is found to contain one primary binding site for medium chain fatty acids which is competitive with the binding of N-acetyl-L-tryptophan. The association constant is higher with nondefatted HSA than with HSA defatted by either heptane-acetic
Amanda J Wade et al.
PloS one, 10(11), e0142770-e0142770 (2015-11-13)
Hepatitis C treatment uptake in Australia is low. To increase access to hepatitis C virus treatment for people who inject drugs, we developed a community-based, nurse-led service that linked a viral hepatitis service in a tertiary hospital to primary care
Eric C Lai et al.
Genome biology, 4(7), R42-R42 (2003-07-08)
MicroRNAs (miRNAs) are a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity. Most miRNAs were identified by direct cloning of small RNAs, an approach that favors detection of abundant miRNAs. Three observations suggested that miRNA genes
Eveline A M Heijnsdijk et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 21(9), 1458-1468 (2012-06-30)
It is recommended that BRCA1/2 mutation carriers undergo breast cancer screening using MRI because of their very high cancer risk and the high sensitivity of MRI in detecting invasive cancers. Clinical observations suggest important differences in the natural history between
H Riediger et al.
Zentralblatt fur Chirurgie, 137(6), 575-579 (2012-12-25)
Pancreatic fistulas are relevant in perioperative outcome, morbidity and mortality after pancreatic head resection. We analysed the potential benefit of an internal pancreatic duct draining technique by a resorbable monofilament suture if performing a two-layer duct-to-mucosa pancreatojejunostomy. From 2006 to
Xiefan Fang et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(12), R1471-R1487 (2014-10-31)
Previous studies demonstrated that in utero caffeine treatment at embryonic day (E) 8.5 alters DNA methylation patterns, gene expression, and cardiac function in adult mice. To provide insight into the mechanisms, we examined cardiac gene and microRNA (miRNA) expression in
David A Oxman et al.
JAMA surgery, 148(5), 440-446 (2013-01-18)
To determine whether extended postoperative antibacterial prophylaxis for patients undergoing elective thoracic surgery with tube thoracostomy reduces the risk of infectious complications compared with preoperative prophylaxis only. Prospective, randomized, double-blind, placebo-controlled trial. Brigham and Women's Hospital, an 800-bed tertiary care
N Prajda et al.
Biochemical pharmacology, 37(5), 875-880 (1988-03-01)
The in vivo actions of two antimetabolites, acivicin (NSC-163501) and tiazofurin (NSC-286193), were examined on the enzymic programs of rat bone marrow. From the bone marrow of the femurs, 100,000 g supernatant fractions were prepared; enzymic activities were measured by
G Teti et al.
Infection and immunity, 61(1), 227-235 (1993-01-01)
Cytokines are suspected of playing an important role in the pathophysiology of septic shock. This study was undertaken to determine whether tumor necrosis factor alpha (TNF-alpha) induces the production of other cytokines and mediates mortality in a neonatal rat model
Tiia Kuuranne et al.
Bioconjugate chemistry, 13(2), 194-199 (2002-03-22)
A new and useful method based on enzyme-assisted synthesis was developed for producing 3 alpha-O-beta-D-glucuronide conjugates from synthetic phase I metabolites of methyltestosterone and nandrolone. The formed glucuronide conjugates of 17 alpha-methyl-5 alpha-androstane-3 alpha,17 beta-diol (I), 17 alpha-methyl-5 beta-androstane-3 alpha,17
Bernhard Banas et al.
BMC immunology, 18(1), 15-15 (2017-03-09)
Uncontrolled cytomegalovirus (CMV) replication in immunocompromised solid-organ transplant recipients is a clinically relevant issue and an indication of impaired CMV-specific cell-mediated immunity (CMI). Primary aim of this study was to assess the suitability of the immune monitoring tool T-Track® CMV
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