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W C Quevedo et al.
Pigment cell research, 3(2), 71-79 (1990-03-01)
Topical applications of monobenzylether of hydroquinone (MBEH) or intraperitoneal injections of phenol induced graying of hair in eumelanic mice but had little effect on hair color in pheomelanic mice. Amcinonide, an anti-inflammatory agent, elicited whitening of a few hairs in
The Seiji memorial lecture. Pigment stories: from vitiligo to melanomas and points in between.
A B Lerner
Pigment cell research, Suppl 2, 19-21 (1992-01-01)
L A Rheins et al.
Journal of immunology (Baltimore, Md. : 1950), 136(3), 867-876 (1986-02-01)
The epidermis on the backs or ears of DBA/2 mice treated for 7 days with a 20% concentration of monobenzyl ether of hydroquinone (MBEH) had a significantly greater population density of ATPase- and Ia-positive cells compared with control mice treated
Torello Lotti et al.
Dermatologic clinics, 25(3), 393-400 (2007-07-31)
This article deals with new and experimental treatments that can be used to treat various forms of depigmenting disorders. Ultraviolet B-focused therapies and new surgical approaches are analyzed in this article. These therapies were mainly or only developed to treat
E Frenk
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 37(1), 1-5 (1986-01-01)
The treatment of vitiligo is still unsatisfactory in many patients. The only two methods that have been evaluated in numerous patients are classic psoralen-light therapy and local treatment with potent fluorinated corticosteroids. These two methods in addition to some more
Jasper G van den Boorn et al.
Pigment cell & melanoma research, 24(4), 673-679 (2011-06-22)
Autoimmune side-effects such as vitiligo regularly occur during melanoma immunotherapy. As vitiligo development is associated with a superior prognosis, the active induction of vitiligo in melanoma patients can be a useful tactic. The potent skin-depigmenting agent monobenzone can be used
A Catona et al.
The Medical journal of Australia, 146(6), 320-321 (1987-03-16)
Three cases of cutaneous depigmentation after the application of Superfade are presented. Almost total depigmentation occurred on the dorsum of the hands with spread of confetti-like depigmentation to the arms. More distant spread occurred in two cases. Superfade contains 1.5%
Treatment of nonhairy melanocytic macules by dermabrasion and topical application of 5% hydroquinone monobenzyl ether cream.
T Tezuka et al.
Journal of the American Academy of Dermatology, 28(5 Pt 1), 771-772 (1993-05-01)
Contact depigmentation of the breast.
A K Bajaj et al.
Contact dermatitis, 24(1), 58-58 (1991-01-01)
Synthesis, spectral properties, biological activity and application of new 4-(benzyloxy) phenol derived azo dyes for polyester fiber dyeing.
Yousefi H, et al.
Journal of Molecular Liquids, 180, 51-58 (2013)
Footwear depigmentation.
A K Bajaj et al.
Contact dermatitis, 35(2), 117-118 (1996-08-01)
Markus A Lill et al.
Journal of medicinal chemistry, 48(18), 5666-5674 (2005-09-02)
We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular dynamics simulations, and linear-interaction energy analysis, we simulated the
K M AlGhamdi et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 25(7), 749-757 (2010-11-09)
If vitiligo involves most of the body, it might be easier to depigment the normal remaining skin rather than to attempt repigmentation. We reviewed the literature to date regarding available therapies for depigmenting the normal skin in vitiligo universalis. Our
K Urabe et al.
Seminars in cutaneous medicine and surgery, 16(1), 81-85 (1997-03-01)
The dyschromatoses are a group of disorders characterized by the presence of both hyperpigmented and hypopigmented macules, many of which are small in size and irregular in shape. There are two major forms-dyschromatosis symmetrica hereditaria (DSH) and dyschromatosis universalis hereditaria
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
Behrooz Kasraee et al.
Experimental dermatology, 15(7), 509-514 (2006-06-10)
Monobenzylether of hydroquinone (MBEH) has long been utilized for the depigmentation therapy of patients with extensive vitiligo. In this approach, the normally pigmented areas surrounding vitiligo lesions are depigmented to achieve a uniform skin tone. One of the important disadvantages
Synthesis, characterization and thermal degradation of functional benzoxazine monomers and polymers containing phenylphosphine oxide.
Choi S-W, et al.
Polymer Degradation and Stability, 91(5), 1166-1178 (2006)
Hearing aid depigmentation.
A K Bajaj et al.
Contact dermatitis, 27(2), 126-127 (1992-08-01)
A case report of extensive vitiligo.
T A Wee
Hawaii medical journal, 56(2), 37-40 (1997-02-01)
M D Njoo et al.
Archives of dermatology, 135(12), 1514-1521 (1999-12-22)
To develop and introduce evidence-based guidelines for the treatment of vitiligo in children and in adults. Patients, residents, and dermatologists from the Department of Dermatology, Academic Medical Center, University of Amsterdam, and the Netherlands Institute for Pigmentary Disorders in Amsterdam.
Achromic patch test from hydroquinone monobenzyl ether.
C Sanz de Galdeano et al.
Contact dermatitis, 29(1), 43-44 (1993-07-01)
Vidhya Hariharan et al.
The Journal of investigative dermatology, 130(1), 211-220 (2009-08-07)
Monobenzyl ether of hydroquinone (MBEH) is a Food and Drug Administration approved drug used for depigmentation therapy of advanced vitiligo. Here, the working mechanism of MBEH is explored in comparison to 4-tertiary butyl phenol (4-TBP), a known causative agent for
[Confetti-like dyschromia caused by a bleaching cream containing hydroquinone in racially pigmented patients].
N Haas
Medizinische Klinik (Munich, Germany : 1983), 83(11), 385-386 (1988-05-13)
Jasper G van den Boorn et al.
The Journal of investigative dermatology, 131(6), 1240-1251 (2011-02-18)
In this study, we report the previously unknown mechanism of inducing robust anti-melanoma immunity by the vitiligo-inducing compound monobenzone. We show monobenzone to increase melanocyte and melanoma cell immunogenicity by forming quinone-haptens to the tyrosinase protein and by inducing the
Contact hypersensitivity to monobenzyl ether of hydroquinone used to treat vitiligo.
C C Lyon et al.
Contact dermatitis, 39(3), 132-133 (1998-10-15)
A M Oakley
The Australasian journal of dermatology, 37(2), 96-98 (1996-05-01)
Repigmentation occurred within a few weeks of discontinuing successful depigmentation therapy with monobenzyl ether of hydroquinone, in a patient with extensive vitiligo. Patients undertaking depigmentation therapy should be warned that this may occur. The mechanism is unknown.
Jonathan G Bonchak et al.
Archives of biochemistry and biophysics, 563, 71-78 (2014-08-19)
Monobenzyl ether of hydroquinone (MBEH) is cytotoxic towards melanocytes. Its treatment efficacy is limited by an inability to eradicate stem cells. By contrast, 8-hydroxy-N,N-dipropyl-2-aminotetralin (8-DPAT) affects melanocyte stem cell survival. MBEH and 8-DPAT were added to melanocytes and melanoma cells
Yiping Zhu et al.
Fitoterapia, 99, 243-251 (2014-08-17)
Epigallocatechin-3-gallate (EGCG) is one of the main chemical constituents of green tea, which has been used as an important traditional Chinese medicine. Green tea has anti-inflammatory, anti-oxidant, and immunomodulatory properties. However, the effects of EGCG on vitiligo are not known.
Jasper G van den Boorn et al.
PloS one, 5(5), e10626-e10626 (2010-05-26)
Presently melanoma still lacks adequate treatment options for metastatic disease. While melanoma is exceptionally challenging to standard regimens, it is suited for treatment with immunotherapy based on its immunogenicity. Since treatment-related skin depigmentation is considered a favourable prognostic sign during
Siavash Toosi et al.
The Journal of investigative dermatology, 132(11), 2601-2609 (2012-06-15)
Vitiligo is characterized by depigmented skin patches caused by loss of epidermal melanocytes. Oxidative stress may have a role in vitiligo onset, while autoimmunity contributes to disease progression. In this study, we sought to identify mechanisms that link disease triggers
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