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Yafei Duan et al.
The Science of the total environment, 754, 141867-141867 (2020-09-09)
Ammonia and thermal stress frequently have harmful effects on aquatic animals. The intestine is an important barrier allowing the body to defend against stress. In this study, we investigated the intestinal microbiota and transcriptomic and metabolomic responses of Litopenaeus vannamei
Shan Jiang et al.
Food research international (Ottawa, Ont.), 137, 109428-109428 (2020-11-26)
Previous studies have reported that phospholipids rich in n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) in the form of liposome exhibited superior bioactivities than other formulation. However, the digestion and absorption characteristics of n-3 LCPUFA-enriched phospholipids were still unclear, restricting
James R Petrie et al.
Frontiers in plant science, 11, 727-727 (2020-07-01)
Plant seeds have long been promoted as a production platform for novel fatty acids such as the ω3 long-chain (≥ C20) polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) commonly found in fish oil. In this article we
N A Wilson et al.
Prostaglandins, leukotrienes, and essential fatty acids, 152, 102037-102037 (2019-12-08)
Omega-3 DHA is important for the prevention of preterm birth, however there is limited knowledge of the determinants of omega-3 status during pregnancy. The primary objective of this systematic review was to synthesise data from existing studies assessing relationships between
María Carmen Sánchez et al.
Microorganisms, 9(2) (2021-03-07)
Microbial biofilm modeling has improved in sophistication and scope, although only a limited number of standardized protocols are available. This review presents an example of a biofilm model, along with its evolution and application in studying periodontal and peri-implant diseases.
Hai Zhang et al.
Frontiers in oncology, 10, 595466-595466 (2020-11-17)
Radiation resistance is linked to immune escaping and radiation sensitivity. In this study, we found that the PD-L1 expressions of non-killed tumor cells in NSCLC were enhanced after radiotherapy, and dihydroartemisinin (DHA) could synergistically enhance the antitumor effect of radiotherapy
N Sáinz et al.
Food & function, 11(10), 9057-9066 (2020-10-07)
Chemerin is a pro-inflammatory adipokine that is increased in obesity and associated with obesity-related comorbidities. The aim of this study was to investigate the effects of omega-3 polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic acids (EPA and DHA), on basal and
Bofeng Wei et al.
Journal of chromatography. A, 1625, 461326-461326 (2020-07-28)
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are essential fatty acids for human body, which are widely used in the field of healthy food and medicine. Meanwhile, there are some differences in their physiological functions, such as "scavenger for blood
Ken Arai et al.
Journal of atherosclerosis and thrombosis, 27(11), 1216-1229 (2020-07-01)
We evaluated the relationship between the ratios of eicosapentaenoic acid and arachidonic acid (EPA/AA), docosahexaenoic acid (DHA)/AA, and delta-5 desaturase activity (D5D) and atherogenic lipid profiles (ALP) and coronary atherosclerosis. Polyunsaturated fatty acids (PUFA) and ALP were assessed in 436
Smitha Padmanabha et al.
Biochemical and biophysical research communications, 529(2), 425-431 (2020-07-25)
Loss of α-crystallin chaperone function results in the lens protein aggregation leading to cataract. In this study, we evaluated the efficacy of micellar lutein with different fatty acids in modulating α-crystallin chaperone function under selenite cataract conditions. Cataract was induced
Xian-Ke Chen et al.
Applied and environmental microbiology, 86(11) (2020-04-05)
Acidophiles play a dominant role in driving elemental cycling in natural acid mine drainage (AMD) habitats and exhibit important application value in bioleaching and bioremediation. Acidity is an inevitable environmental stress and a key factor that affects the survival of
Yunzhi Liu et al.
Oxidative medicine and cellular longevity, 2020, 8096847-8096847 (2020-09-11)
Acetaminophen (APAP) toxicity is the leading cause of drug-induced liver failure, which is closely related to mitochondrial dysfunction and oxidative damage. Studies in clinical trials and in animal models have shown that omega-3 polyunsaturated fatty acids (n-3 PUFAs) affect the
Shiqi Yuan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 126, 110102-110102 (2020-03-22)
Monocytes play a crucial role in Alzheimer's disease (AD), and docosahexaenoic acid (DHA) has a neuroprotective effect for many neurodegenerative diseases. However, mechanisms that regulate monocyte and Aβ protein interaction in AD and the effects of DHA on monocytes in
Tamara Hoppenbrouwers et al.
Frontiers in immunology, 11, 748-748 (2020-05-21)
Allergy is becoming a rapidly increasing problem worldwide, and in vitro models are frequently used to study the mechanisms behind the different types of allergic response. The dendritic cell (DC)-T-cell model can be used to study sensitization. However, lipopolysaccharide (LPS)
Michael J Lynch et al.
Nature chemical biology, 15(10), 959-965 (2019-08-14)
The flagellar hook protein FlgE from spirochaete bacteria self-catalyzes the formation of an unusual inter-subunit lysinoalanine (Lal) crosslink that is critical for cell motility. Unlike other known examples of Lal biosynthesis, conserved cysteine and lysine residues in FlgE spontaneously react
Angela Maria Rizzo et al.
Cells, 10(1) (2021-01-21)
(1) Background: Lipid metabolism is a fundamental hallmark of all tumors, especially of breast cancer. Few studies describe the different lipid metabolisms and sensitivities to the microenvironment of breast cancer cell subtypes that influence the proliferation, aggressiveness, and success of
Catherine Chunda-Liyoka et al.
BMC pregnancy and childbirth, 20(1), 93-93 (2020-02-12)
Nut butter-based Ready to Use Supplemental Foods (RUSF) are an effective way to add nutrients and calories to diets of malnourished and food insecure populations. The RUSF formulations have been further modified to add micronutrients including iron and folic acid
Walaa F Awadin et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 228, 108668-108668 (2019-11-13)
This study was performed to evaluate the effects of omega-3 supplementation on growth performance, clinical signs, post-mortem lesions, haemagglutination inhibition (HI) antibody titres, gene expression and histopathology in quails (Coturnix coturnix japonica) infected with Newcastle disease virus (NDV) and avian
Ahmed A Elmarakby et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1864(11), 1669-1680 (2019-07-28)
Recent studies suggest a potential role of bioactive lipids in acute kidney injury induced by lipopolysaccharide (LPS). The current study was designed to determine the profiling activities of various polyunsaturated fatty acid (PUFA) metabolizing enzymes, including lipoxygenases (LO), cyclooxygenase, and
Yvoni Kyriakidou et al.
Journal of the International Society of Sports Nutrition, 18(1), 9-9 (2021-01-15)
Exercise-induced muscle damage (EIMD) results in transient muscle inflammation, strength loss, muscle soreness and may cause subsequent exercise avoidance. Omega-3 (n-3) supplementation may minimise EIMD via its anti-inflammatory properties, however, its efficacy remains unclear. Healthy males (n = 14, 25.07 ± 4.05 years) were randomised
Chukwudi O Onwosi et al.
Environmental technology, 41(24), 3178-3190 (2019-04-16)
We investigated a number of microbiological activities in the soil to serve as biomonitoring tools in assessing the ecotoxicity of diesel-contaminated soil samples during the different periods of bioremediation. Sawdust was used as the biostimulant for the biodegradation of artificial
Thomas R Lane et al.
Antiviral research, 182, 104908-104908 (2020-08-18)
We have recently identified three molecules (tilorone, quinacrine and pyronaridine tetraphosphate) which all demonstrated efficacy in the mouse model of infection with mouse-adapted Ebola virus (EBOV) model of disease and had similar in vitro inhibition of an Ebola pseudovirus (VSV-EBOV-GP)
Cynthia Aslan et al.
Life sciences, 258, 118094-118094 (2020-07-17)
Docosahexaenoic acid (DHA) as an omega 3 free fatty acid has been reported to exert anti-angiogenesis effects. However, our current understanding regarding the precise mechanisms of such effects is still limited. Exosomes secreted by cancer cells may act as angiogenesis
DHA Attenuates Hypoxia/Reoxygenation Injury by Activating SSeCKS in Human Cerebrovascular Pericytes.
Yanli Yu et al.
Neurochemical research, 45(2), 310-321 (2019-11-30)
Docosahexaenoic acid (DHA) can alleviate cerebral ischemia/reperfusion injury by reducing blood-brain barrier permeability and maintaining its integrity, accompanied by an increased Ang-1/Ang-2 ratio; however, the underlying mechanisms of these effects remain unclear. Src-suppressed C kinase substrates (SSeCKS), a substrate of
Yan Luo et al.
Toxicology and applied pharmacology, 403, 115159-115159 (2020-07-30)
Dihydroartemisinin (DHA) is an artemisinin derivative commonly used in malaria therapy, and a growing number of studies have focused on the potent anticancer activity of DHA. However, the reproductive toxicity of anticancer drugs is a major concern for young female
Jeffrey L Barr et al.
Neuroscience letters, 735, 135196-135196 (2020-06-26)
Docosahexaenoic acid (DHA) an omega-3 polyunsaturated fatty acid, is an agonist of FFA1 receptor. DHA administration reduces the heart rate via unclear mechanisms. We examined the effect of DHA on neurons of nucleus ambiguus that provide the parasympathetic control of
Rodrigo Carrasco et al.
Trials, 21(1), 137-137 (2020-02-06)
Anthracycline-induced cardiotoxicity (AIC), a condition associated with multiple mechanisms of damage, including oxidative stress, has been associated with poor clinical outcomes. Carvedilol, a β-blocker with unique antioxidant properties, emerged as a strategy to prevent AIC, but recent trials question its
Lili Zhu et al.
Frontiers in pharmacology, 11, 587470-587470 (2021-03-05)
Dihydroartemisinin (DHA), a sesquiterpene lactone with endoperoxide bridge, is one of the derivatives of artemisinin. In addition to having good antimalarial properties, DHA exhibits anticancer effects including against malignant solid tumors. However, the mechanism by which DHA inhibits the progression
Évelin Maria Brand et al.
PloS one, 14(10), e0222786-e0222786 (2019-10-03)
TB/HIV coinfection is a serious public health issue in Brazil, and patients with coinfection have difficulty adhering to treatments. Directly observed treatment (DOT) has been recommended by the World Health Organization, considering the vulnerability of those affected. The purpose is
Janne Bredehöft et al.
ACS chemical neuroscience, 10(10), 4394-4406 (2019-09-13)
Lipids, including omega-3 polyunsaturated fatty acids (n-3-PUFAs), modulate brain-intrinsic inflammation during systemic inflammation. The vascular organ of the lamina terminalis (OVLT) is a brain structure important for immune-to-brain communication. We, therefore, aimed to profile the distribution of several lipids (e.g.
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