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Hun-Goo Lee et al.
Genome research, 25(8), 1170-1181 (2015-05-20)
Polycomb group (PcG) complexes PRC1 and PRC2 are well known for silencing specific developmental genes. PRC2 is a methyltransferase targeting histone H3K27 and producing H3K27me3, essential for stable silencing. Less well known but quantitatively much more important is the genome-wide
Alexander J Moszczynski et al.
Neurobiology of aging, 36(3), 1590-1599 (2015-01-13)
We have previously shown that amyotrophic lateral sclerosis with cognitive impairment can be characterized by pathologic inclusions of microtubule-associated protein tau (tau) phosphorylated at Thr(175) (pThr(175)) in association with GSK3β activation. We have now examined whether pThr(175) induces GSK3β activation
Praveen Prakhar et al.
The Journal of biological chemistry, 290(44), 26576-26586 (2015-09-24)
Specific and coordinated regulation of innate immune receptor-driven signaling networks often determines the net outcome of the immune responses. Here, we investigated the cross-regulation of toll-like receptor (TLR)2 and nucleotide-binding oligomerization domain (NOD)2 pathways mediated by Ac2PIM, a tetra-acylated form
Anna Vallverdú-Queralt et al.
International journal of molecular sciences, 16(5), 9588-9599 (2015-05-01)
The consumption of carotenoid-rich vegetables such as tomatoes and tomato sauces is associated with reduced risk of several chronic diseases. The predominant carotenoids in tomato products are in the (all-E) configuration, but (Z) isomers can be formed during thermal processing.
Bjoern Traenkle et al.
Molecular & cellular proteomics : MCP, 14(3), 707-723 (2015-01-18)
β-catenin is the key component of the canonical Wnt pathway and plays a crucial role in a multitude of developmental and homeostatic processes. The different tasks of β-catenin are orchestrated by its subcellular localization and participation in multiprotein complexes. To
Florian E Kiene et al.
Journal of pharmaceutical and biomedical analysis, 110, 20-26 (2015-03-24)
Pharmaceutical excipients containing volatile odor-active molecules can be used in pharmaceutical development to increase patients' compliance. However, capturing the molecular composition of these odor-active substances is challenging. Therefore, guidance for the analytical investigation of these excipients should be developed. Using
Roza K Przanowska et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(6), 7687-7702 (2020-04-12)
miR-206, miR-1a-1, and miR-1a-2 are induced during differentiation of skeletal myoblasts and promote myogenesis in vitro. miR-206 is required for skeletal muscle regeneration in vivo. Although this miRNA family is hypothesized to play an essential role in differentiation, a triple
Claire Regazzetti et al.
The Journal of investigative dermatology, 135(12), 3105-3114 (2015-09-01)
Vitiligo affects 1% of the worldwide population. Halting disease progression and repigmenting the lesional skin represent the two faces of therapeutic challenge in vitiligo. We performed transcriptome analysis on lesional, perilesional, and non-depigmented skin from vitiligo patients and on matched
Fei Gao et al.
Scientific reports, 5, 13863-13863 (2015-09-10)
Appropriate regulation of regional uterine stromal cell decidualization in implantation, at the mesometrial triangle and secondary decidual zone (SDZ) locations, is critical for successful pregnancy, although the regulatory mechanisms remain poorly understood. In this regard, the available animal models that
Ahmed Chahdi et al.
The Journal of biological chemistry, 288(47), 34019-34029 (2013-10-17)
Wnt/β-catenin signaling is highly regulated and critical for intestinal epithelial development and repair; aberrant β-catenin signaling is strongly associated with colon cancer. The small GTPase Rac1 regulates β-catenin nuclear translocation and signaling. Here we tested the hypothesis that β1Pix, a
Amitava Adhikary et al.
Journal of the American Chemical Society, 131(24), 8614-8619 (2009-05-28)
In this work, it is shown that the incorporation of an 8-deuteroguanine (G*) moiety in DNA-oligomers allows for direct determination at 77 K of (i) the location of holes (i.e., the radical site) within dsDNA at specific base sites, even
H M Chen et al.
Translational psychiatry, 4, e375-e375 (2014-08-15)
Bipolar disorder (BP) is a chronic psychiatric condition characterized by dynamic, pathological mood fluctuations from mania to depression. To date, a major challenge in studying human neuropsychiatric conditions such as BP has been limited access to viable central nervous system
Weiwei Gao et al.
Carcinogenesis, 34(6), 1208-1215 (2013-02-08)
We recently reported that an N-terminally truncated retinoid X receptor-α (tRXRα) produced in cancer cells acts to promote cancer cell growth and survival through AKT activation. However, how RXRα is cleaved and how the cleavage is regulated in cancer cells
Chiung-Kuei Huang et al.
Journal of hepatology, 63(1), 191-198 (2015-03-01)
Alcoholic liver disease (ALD) is characterized by the development of fatty liver, alcoholic hepatitis, fibrosis and cirrhosis. However, the underlying mechanism(s) associated with progression remains elusive. Pro-inflammatory cytokines have been implicated in ALD progression due to pro-apoptotic effects on hepatocytes.
Jia-Hui Lin et al.
Physical chemistry chemical physics : PCCP, 17(23), 15124-15130 (2015-03-31)
This study describes the synthesis of fluorescent polydopamine dots (PDs) through hydroxyl radical-induced degradation of polydopamine nanoparticles. The decomposition of polydopamine nanoparticles to fluorescent PDs was confirmed using transmission electron microscopy and dark-field microscopy. The analysis of PDs by using
Mini Bajaj et al.
Applied microbiology and biotechnology, 99(22), 9835-9846 (2015-08-01)
Extraction of chitin from mechanically pre-purified shrimp shells can be achieved by successive NaOH/HCl treatment, protease/HCl treatment or by environmentally friendly fermentation with proteolytic/lactic acid bacteria (LAB). For the last mentioned alternative, scale-up of shrimp shell chitin purification was investigated
V de Brun et al.
Journal of animal physiology and animal nutrition, 99(4), 710-718 (2014-10-17)
This study investigated whether a 22-day period of undernutrition (half maintenance) could affect maternal endocrine responses and liver gene expression during early pregnancy (day 7). Thirty-five ewes were fed 1.5 (n = 15) or 0.5 (n = 20) their maintenance requirements and slaughtered on
Steven Zukerman et al.
Chemical senses, 34(8), 685-694 (2009-09-09)
Prior work has shown that sweet taste-deficient T1R3 knockout (KO) mice developed significant sucrose preferences when given long-term sugar versus water tests. The current study investigated the role of olfaction in this experience-conditioned sucrose preference. T1R3 KO and C57BL/6 wild-type
Kamal Shokeen et al.
Virus research, 292, 198223-198223 (2020-11-10)
Newcastle disease is a severe clinical manifestation of avian species caused by Newcastle disease virus (NDV). Although several vaccination strategies are available to protect poultry against NDV infection, even then, outbreaks have been reported in the vaccinated birds. The lack
Ulrike Lambertz et al.
BMC genomics, 16, 151-151 (2015-03-15)
Leishmania use exosomes to communicate with their mammalian hosts and these secreted vesicles appear to contribute to pathogenesis by delivering protein virulence factors to macrophages. In other eukaryotes, exosomes were found to carry RNA cargo, such as mRNAs and small
Y Shetzer et al.
Cell death and differentiation, 21(9), 1419-1431 (2014-05-17)
p53 loss of heterozygosity (p53LOH) is frequently observed in Li-Fraumeni syndrome (LFS) patients who carry a mutant (Mut) p53 germ-line mutation. Here, we focused on elucidating the link between p53LOH and tumor development in stem cells (SCs). Although adult mesenchymal
Ali Reza Kamali et al.
Nanoscale, 7(26), 11310-11320 (2015-06-09)
Experimental evidence for high temperature diffusion of hydrogen into the interlayer space of graphite is provided. This process is discussed as a possible method for the rapid production of high-quality, inexpensive graphene in large quantities, which could lead to the
Tomonaga Ichikawa et al.
Cellular signalling, 27(10), 2087-2098 (2015-07-26)
N-myc downstream-regulated gene 2 (NDRG2) is one of the important stress-inducible genes and plays a critical role in negatively regulating PI3K/AKT signaling during hypoxia and inflammation. Through recruitment of PP2A phosphatase, NDRG2 maintains the dephosphorylated status of PTEN to suppress
Haoyu Liu et al.
Carbohydrate polymers, 113, 480-489 (2014-09-27)
Polymer design and selection are crucial to the development of amorphous solid dispersions (ASD) for solubilization of otherwise poorly water-soluble drugs. The matrix polymer is required to interact strongly at the molecular level with the drug to prevent recrystallization, but
Victor R de la Rosa et al.
Organic & biomolecular chemistry, 13(10), 3048-3057 (2015-01-27)
A poly[(2-ethyl-2-oxazoline)-ran-(2-nonyl-2-oxazoline)] random copolymer was synthesized and its thermoresponsive behavior in aqueous solution modulated by the addition of different supramolecular host molecules. The macrocycles formed inclusion complexes with the nonyl aliphatic side-chains present in the copolymer, increasing its cloud point
Frantisek Jursky et al.
European journal of pharmacology, 765, 1-6 (2015-08-15)
We previously identified cysteine 475 as a key residue for the inhibitory action of sanguinarine on the human glycine transporter GlyT1c. To define potential benzophenanthridine binding pocket more closely, we created a structural homology model of GlyT1 and also mutated
Giulia Zanni et al.
Developmental neuroscience, 37(3), 263-272 (2015-06-06)
Radiotherapy is common in the treatment of brain tumors in children but often causes deleterious, late-appearing sequelae, including cognitive decline. This is thought to be caused, at least partly, by the suppression of hippocampal neurogenesis. However, the changes in neuronal
Yoshikazu Taketa et al.
Journal of toxicologic pathology, 28(4), 217-224 (2015-11-06)
Magnetic resonance imaging (MRI) is a useful noninvasive tool used to detect lesions in clinical and veterinary medicine. The present study evaluated the suitability of a new easy-to-use compact MRI platform (M2 permanent magnet system, Aspect Imaging, Shoham, Israel) for
Linlin Zhang et al.
International journal of nanomedicine, 10, 2913-2924 (2015-05-02)
Our prior screening of microRNAs (miRs) identified that miR-199a-3p expression is reduced in osteosarcoma cells, one of the most common types of bone tumor. miR-199a-3p exhibited functions of tumor cell growth inhibition, suggesting the potential application of miR-199a-3p as an
Roberto Gedaly et al.
PloS one, 9(6), e99272-e99272 (2014-06-19)
Activation of the Wnt/β-catenin pathway has been observed in at least 1/3 of hepatocellular carcinomas (HCC), and a significant number of these have mutations in the β-catenin gene. Therefore, effective inhibition of this pathway could provide a novel method to
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