21223

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Treatment of malar and midfacial fractures with osteoconductive forged unsintered hydroxyapatite and poly-L-lactide composite internal fixation devices.

Constantin Landes et al.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 72(7), 1328-1338 (2014-04-08)

To evaluate the internal fixation of malar and midfacial fractures, long-term results, and biocompatibility of osteoconductive internal fixation devices composed of a forged composite of unsintered hydroxyapatite and poly-L-lactide (F-u-HA/PLLA). From January 2006 to June 2010, 29 patients (24 males

Osteogenesis of cryopreserved osteogenic matrix cell sheets.

Takamasa Shimizu et al.

Cryobiology, 66(3), 326-332 (2013-04-09)

Cryopreservation of tissue engineered bone (TEB), whilst maintaining its osteogenic ability, is imperative for large-scale clinical application. We previously reported a novel cell transplantation method, in which bone-marrow-derived mesenchymal stem cells (BMSCs) were cultured to confluence and differentiated down the

Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge.

Francisco Miguel Cardoso et al.

Journal of virology, 88(15), 8278-8296 (2014-05-16)

Influenza virus neuraminidase (NA) is an interesting target of small-molecule antiviral drugs. We isolated a set of H5N1 NA-specific single-domain antibodies (N1-VHHm) and evaluated their in vitro and in vivo antiviral potential. Two of them inhibited the NA activity and

Hydroxyapatite and calcified elastin induce osteoblast-like differentiation in rat aortic smooth muscle cells.

Yang Lei et al.

Experimental cell research, 323(1), 198-208 (2014-01-23)

Vascular calcification can be categorized into two different types. Intimal calcification related to atherosclerosis and elastin-specific medial arterial calcification (MAC). Osteoblast-like differentiation of vascular smooth muscle cells (VSMCs) has been shown in both types; however, how this relates to initiation

Prevention of enamel demineralization with a novel fluoride strip: enamel surface composition and depth profile.

Bor-Shiunn Lee et al.

Scientific reports, 5, 13352-13352 (2015-08-22)

There is no topically applicable low concentration fluoride delivery device available for caries prevention. This study was aimed to assess the use of a low concentration (1450 ppm) fluoride strip as an effective fluoride delivery system against enamel demineralization. The enamel

Severe mandibular atrophy treated with a subperiosteal implant and simultaneous graft with rhBMP-2 and mineralized allograft: a case report.

Cosimo Loperfido et al.

The Journal of oral implantology, 40(6), 707-713 (2013-04-12)

A 71-year-old patient was successfully rehabilitated by means of a 3D model-derived, hydroxyapatite-coated titanium subperiosteal mandibular implant. The implant was specifically designed to allow bone augmentation. The deficient bone was simultaneously grafted with mineralized bone allograft and recombinant bone morphogenetic

Coated vs uncoated implants: bone defect configurations after progressive peri-implantitis in dogs.

Marwa Madi et al.

The Journal of oral implantology, 40(6), 661-669 (2013-01-08)

In this study, hydroxyapatite coated vs uncoated implants were used to evaluate the type and dimensions of bone defects after progressive peri-implantitis in dogs. Thirty-two dental implants with 4 different surfaces-machined (M), sandblasted acid-etched (SA), 1-μm thin sputter hydroxyapatite (HA)-coated

Enhancement of osteoinduction by continual simvastatin release from poly(lactic-co-glycolic acid)-hydroxyapatite-simvastatin nano-fibrous scaffold.

Liming Jiang et al.

Journal of biomedical nanotechnology, 9(11), 1921-1928 (2013-09-26)

Simvastatin is considered as a stimulator for bone formation. However, the half-life for simvastatin is generally 2 hours, which means, it is difficult to maintain biologically active simvastatin in vivo. To overcome this limitation, we created a system to slowly

Nano-hydroxyapatite modulates osteoblast lineage commitment by stimulation of DNA methylation and regulation of gene expression.

Shin-Woo Ha et al.

Biomaterials, 65, 32-42 (2015-07-05)

Hydroxyapatite (HA) is the primary structural component of the skeleton and dentition. Under biological conditions, HA does not occur spontaneously and therefore must be actively synthesized by mineralizing cells such as osteoblasts. The mechanism(s) by which HA is actively synthesized

Cobalt doped proangiogenic hydroxyapatite for bone tissue engineering application.

Senthilguru Kulanthaivel et al.

Materials science & engineering. C, Materials for biological applications, 58, 648-658 (2015-10-20)

The present study delineates the synthesis and characterization of cobalt doped proangiogenic-osteogenic hydroxyapatite. Hydroxyapatite samples, doped with varying concentrations of bivalent cobalt (Co(2+)) were prepared by the ammoniacal precipitation method and the extent of doping was measured by ICP-OES. The

Biphasic β-TCP mixed with silicon increases bone formation in critical site defects in rabbit calvaria.

José Luis Calvo-Guirado et al.

Clinical oral implants research, 26(8), 891-897 (2014-05-28)

The aim of this study was to assess the bone regeneration of critical size defects in rabbit calvarias filled with β-TCP doped with silicon. Twenty-one New Zealand rabbits were used in this study. Two critical size defects were created in

Bone apposition on implants coated with calcium phosphate by ion beam assisted deposition in oversized drilled sockets: a histologic and histometric analysis in dogs.

Min-Soo Kim et al.

Journal of periodontal & implant science, 43(1), 18-23 (2013-03-20)

The purpose of this study was to evaluate the osseointegration of calcium phosphate (CaP)-coated implants by ion beam assisted deposition with a lack of primary stability. A total of 20 CaP-coated implants were bilaterally placed in the mandible of five

Implant materials generate different peri-implant inflammatory factors: poly-ether-ether-ketone promotes fibrosis and microtextured titanium promotes osteogenic factors.

Rene Olivares-Navarrete et al.

Spine, 40(6), 399-404 (2015-01-15)

An in vitro study examining factors produced by human mesenchymal stem cells on spine implant materials. The aim of this study was to examine whether the inflammatory microenvironment generated by cells on titanium-aluminum-vanadium (Ti-alloy, TiAlV) surfaces is affected by surface

Role of Lipocalin-type prostaglandin D2 synthase (L-PGDS) and its metabolite, prostaglandin D2, in preterm birth.

Sunil Kumar et al.

Prostaglandins & other lipid mediators, 118-119, 28-33 (2015-05-13)

The objective of the study was to investigate the role of prostaglandin D2 during pregnancy and its mediator Lipocalin-type prostaglandin D2 synthase (L-PGDS) as a predictor of preterm birth (PTB). Transgenic L-PGDS (+/+), L-PGDS (-/-) and C57BL/6 control pregnant mice

The effects of atorvastatin on the prevention of osteoporosis and dyslipidemia in the high-fat-fed ovariectomized rats.

Sien Lin et al.

Calcified tissue international, 96(6), 541-551 (2015-03-31)

Previous studies reported that statins showed positive effects on bone in both human and animal models. This study aimed to investigate the effects of atorvastatin on the prevention of osteoporosis and dyslipidemia in ovariectomized rats fed with high-fat emulsion. The

Surface characterization and osteoblast response to a functionally graded hydroxyapatite/fluoro-hydroxyapatite/titanium oxide coating on titanium surface by sol-gel method.

G He et al.

Cell proliferation, 47(3), 258-266 (2014-04-18)

To improve efficacy of current titanium and its alloys, in bioactivity and speed of osseointegration, of orthopaedic implants. A novel triple-layered functional graded coating, consisting of a porous hydroxyapatite (HA) outermost layer, fluoro-HA (FHA) intermediate layer and titanium oxide (TiO2

Immunogold Localization of Key Metabolic Enzymes in the Anammoxosome and on the Tubule-Like Structures of Kuenenia stuttgartiensis.

Naomi M de Almeida et al.

Journal of bacteriology, 197(14), 2432-2441 (2015-05-13)

Anaerobic ammonium-oxidizing (anammox) bacteria oxidize ammonium with nitrite as the terminal electron acceptor to form dinitrogen gas in the absence of oxygen. Anammox bacteria have a compartmentalized cell plan with a central membrane-bound "prokaryotic organelle" called the anammoxosome. The anammoxosome

Characterization of biomimetic calcium phosphate labeled with fluorescent dextran for quantification of osteoclastic activity.

Salwa M Maria et al.

Acta biomaterialia, 20, 140-146 (2015-04-02)

Bone resorbing osteoclasts represent an important therapeutic target for diseases associated with bone and joint destruction, such as rheumatoid arthritis, periodontitis, and osteoporosis. The quantification of osteoclast resorptive activity in vitro is widely used for screening new anti-resorptive medications. The

Nanohydroxyapatite incorporated electrospun polycaprolactone/polycaprolactone-polyethyleneglycol-polycaprolactone blend scaffold for bone tissue engineering applications.

K R Remya et al.

Journal of biomedical nanotechnology, 9(9), 1483-1494 (2013-08-29)

The present work is a comparative evaluation of physical and biological properties of electrospun biodegradable fibrous scaffolds based on polycaprolactone (PCL) and its blend with polycaprolactone-polyethyleneglycol-polycaprolactone (CEC) with and without nanohydroxyapatite (nHAP) particles. The fiber morphology, porosity, surface wettability, and

A comparison of tissue engineering based repair of calvarial defects using adipose stem cells from normal and osteoporotic rats.

Ming Pei et al.

Bone, 78, 1-10 (2015-05-06)

Repairing large bone defects presents a significant challenge, especially in those people who have a limited regenerative capacity such as in osteoporotic (OP) patients. The aim of this study was to compare adipose stem cells (ASCs) from both normal (NORM)

Mechanical study of polycaprolactone-hydroxyapatite porous scaffolds created by porogen-based solid freeform fabrication method.

Lin Lu et al.

Journal of applied biomaterials & functional materials, 12(3), 145-154 (2014-01-16)

Polycaprolactone (PCL) and polycaprolactone-hydroxyapatite (PCL-HA) scaffolds with 600-µm pore size were fabricated by drop-on-demand printing (DDP) structured porogen method followed with injection molding. Specimens with special dimensions of 4.2×4.2×5.4 mm3 and 6.6×6.6×13.8 mm3 were designed and fabricated for compression and

Extracellular Glycoside Hydrolase Activities in the Human Oral Cavity.

Taichi Inui et al.

Applied and environmental microbiology, 81(16), 5471-5476 (2015-06-07)

Carbohydrate availability shifts when bacteria attach to a surface and form biofilm. When salivary planktonic bacteria form an oral biofilm, a variety of polysaccharides and glycoproteins are the primary carbon sources; however, simple sugar availabilities are limited due to low

Synthesis of carboxylic block copolymers via reversible addition fragmentation transfer polymerization for tooth erosion prevention.

Y Lei et al.

Journal of dental research, 93(12), 1264-1269 (2014-09-25)

Dental professionals are seeing a growing population of patients with visible signs of dental erosion. The approach currently being used to address the problem typically leverages the enamel protection benefits of fluoride. In this report, an alternative new block copolymer

Biomimetic approaches in bone tissue engineering: Integrating biological and physicomechanical strategies.

Marc A Fernandez-Yague et al.

Advanced drug delivery reviews, 84, 1-29 (2014-09-23)

The development of responsive biomaterials capable of demonstrating modulated function in response to dynamic physiological and mechanical changes in vivo remains an important challenge in bone tissue engineering. To achieve long-term repair and good clinical outcomes, biologically responsive approaches that

Blindness caused by cosmetic filler injection: a review of cause and therapy.

Jean D A Carruthers et al.

Plastic and reconstructive surgery, 134(6), 1197-1201 (2014-11-22)

Vascular occlusion causing blindness is a rare yet greatly feared complication of the use of facial aesthetic fillers. The authors performed a review of the aesthetic literature to ascertain the reported cases of blindness and the literature reporting variations in

Anodic TiO2 nanotubular arrays with pre-synthesized hydroxyapatite--an effective approach to enhance the biocompatibility of titanium.

Lu-Ning Wang et al.

Journal of nanoscience and nanotechnology, 13(8), 5316-5326 (2013-07-26)

Electrochemically anodized TiO2 nanotubular arrays can provide large surface areas for biological species attachment. In order to further enhance the biocompatibility of Ti medical implants, we deposited a pre-synthesized hydroxyapatite inside and on the nanotubular arrays, and examined the biocompatibility

Cytocompatibility of the selected calcium phosphate based bone cements: comparative study in human cell culture.

Radosław Olkowski et al.

Journal of materials science. Materials in medicine, 26(12), 270-270 (2015-10-30)

Calcium phosphate cements (CPC) are valuable bone fillers. Recently they have been also considered as the basis for drug-, growth factors- or cells-delivery systems. Broad possibilities to manipulate CPC composition provide a unique opportunity to obtain materials with a wide

Outcomes of long tapered hydroxyapatite-coated stems in revision total hip arthroplasty.

Amun Makani et al.

The Journal of arthroplasty, 29(4), 827-830 (2013-09-28)

The purpose of this study was to evaluate the outcome of femoral component revisions using a long tapered HA coated femoral revision stem. Between 2001 and 2008, 55 femoral component revisions were performed using this stem. Forty-one patients were available

DNA-binding studies of AV-153, an antimutagenic and DNA repair-stimulating derivative of 1,4-dihydropiridine.

E Buraka et al.

Chemico-biological interactions, 220, 200-207 (2014-07-13)

The ability to intercalate between DNA strands determines the cytotoxic activity of numerous anticancer drugs. Strikingly, intercalating activity was also reported for some compounds considered to be antimutagenic. The aim of this study was to determine the mode of interaction

Design and in vitro evaluation of simvastatin-hydroxyapatite coatings by an electrochemical process on titanium surfaces.

Zhao Shifang et al.

Journal of biomedical nanotechnology, 10(7), 1313-1319 (2014-05-09)

The aim of this study was to deposit simvastatin-hydroxyapatite (sim-HA) coatings on titanium surfaces by an electrochemical process and evaluate osteoprogenitor cell responses to sim-HA-coated surfaces. Simvastatin was prepared onto titanium surfaces with varying concentration (10(-7), 10(-6), 10(-5) and 10(-4)

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