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Yang Sun et al.
American journal of respiratory cell and molecular biology, 51(6), 738-749 (2014-05-31)
Lymphangioleiomyomatosis (LAM) is a female-predominant cystic lung disease that can lead to respiratory failure. LAM cells typically have inactivating tuberous sclerosis complex 2 (TSC2) mutations and mammalian target of rapamycin (mTOR) complex (mTORC) 1 activation. Clinical response to the mTORC1
Tsuyoshi Majima et al.
Human gene therapy, 26(11), 734-742 (2015-07-24)
Increased afferent excitability has been proposed as an important pathophysiology of interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder (OAB). In this study, we investigated whether herpes simplex virus (HSV) vectors encoding poreless TRPV1, in which the segment in C
Daisuke Masuda et al.
Molecular medicine reports, 12(5), 7303-7309 (2015-10-16)
Ki-67 is a nuclear protein that is expressed during the G1, S, G2 and M phases of the mitotic cell cycle. A previous study categorized tumor infiltration patterns (INF), of which INFc indicated cancer nests exhibiting infiltrative growth and an
Jingming Li et al.
Journal of diabetes research, 2015, 963289-963289 (2015-04-14)
NADPH oxidase 4 (Nox4) is a major isoform of NADPH oxidase in retinal endothelial cells. Our previous study suggests that upregulation of Nox4 in retinal endothelial cells contributes to retinal vascular leakage in diabetes. In the current study, we investigated
Changsheng Xing et al.
Neoplasia (New York, N.Y.), 16(11), 883-899 (2014-11-27)
Krüppel-like factor 5 (KLF5) regulates multiple biologic processes. Its function in tumorigenesis appears contradictory though, showing both tumor suppressor and tumor promoting activities. In this study, we examined whether and how Klf5 functions in prostatic tumorigenesis using mice with prostate-specific
Abdulkader Albasri et al.
Anticancer research, 34(8), 3969-3974 (2014-07-31)
To determine whether phosphorylated focal adhesion kinase (P-FAK) has prognostic value in colorectal cancer (CRC) and to test whether it has any association with Tensin 4 (TNS4) expression. P-FAK expression was assessed using immunohistochemistry in 462 CRC cases arrayed on
Bizunesh M Borena et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 34(4), 1291-1303 (2014-10-04)
Mammal skin plays a pivotal role in several life preserving processes and extensive damage may therefore be life threatening. Physiological skin regeneration is achieved through ongoing somatic stem cell differentiation within the epidermis and the hair follicle. However, in severe
E S Shilov et al.
Biochemistry. Biokhimiia, 79(12), 1412-1422 (2015-02-27)
Cytochrome c is an indispensable electron carrier in the mitochondrial respiratory chain and also an important mediator of the internal pathway triggering apoptosis. Mice with a complete deficiency of the Cycs gene encoding the somatic cytochrome c die during the
Yuan-Ji Day et al.
Pain, 155(7), 1293-1302 (2014-04-12)
Interleukin-17 (IL-17) is involved in a wide range of inflammatory disorders and in recruitment of inflammatory cells to injury sites. A recent study of IL-17 knock-out mice revealed that IL-17 contributes to neuroinflammation and neuropathic pain after peripheral nerve injury.
T Ileri Keceli et al.
Oral diseases, 21(1), 66-73 (2013-11-20)
The study aimed to investigate the clinical and microbiological effects of tongue brushing on malodour in children. One hundred and fifty-one caries-free children were included. After clinical evaluation, halitosis was determined by organoleptic assessment and sulphide monitoring. Then, 69 children
Luciano L Furlanetti et al.
Experimental brain research, 233(11), 3073-3085 (2015-07-22)
Preclinical and clinical evidence suggests that depression might be associated with a dysfunction in the reward/motivation circuitry. Deep brain stimulation (DBS) of the superolateral branch of the medial forebrain bundle (MFB) has been shown in a recent clinical trial to
Tonia S Schwartz et al.
Experimental gerontology, 71, 135-146 (2015-09-26)
Mitochondrial function has long been hypothesized to be intimately involved in aging processes--either directly through declining efficiency of mitochondrial respiration and ATP production with advancing age, or indirectly, e.g., through increased mitochondrial production of damaging free radicals with age. Yet
Annabelle Tavernier et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(9), 4100-4110 (2014-06-15)
The importance of B-isoform of leptin receptor (LEPR-B) signaling in the hypothalamus, pancreas, or liver has been well characterized, but in the intestine, a unique site of entry for dietary nutrition into the body, it has been relatively ignored. To
Junfeng Liu et al.
Experimental and therapeutic medicine, 10(5), 1657-1664 (2015-12-08)
Inflammation and hyperproliferation of pulmonary artery smooth muscle cells (PASMCs) is considered the primary pathological feature of pulmonary hypertension (PH). The present study determined that mesenchymal stem cells (MSCs) suppress the expression of calcineurin (CaN) and nuclear factor of activated
Joanne D Du et al.
International journal of pharmaceutics, 471(1-2), 358-365 (2014-06-01)
Targeted drug delivery to the buccal mucosa offers distinct advantages over oral delivery to the gastrointestinal tract including by-passing hepatic first-pass metabolism. However, the buccal route is often limited by low bioavailability, low drug loading and reduced residence time due
Junghoon Oh et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(16), 6241-6246 (2015-03-12)
Three-dimensional (3D) carbon nitride (C3 N4 )-based materials show excellent performance in a wide range of applications because of their suitable band structures. To realize the great promise of two-dimensional (2D) allotropes of various 3D materials, it is highly important
Saida Haider et al.
Life sciences, 124, 110-119 (2015-02-01)
D-Galactose (D-gal) induced accelerated senescence has been used to develop an aging model for brain. Previously, long term administration of a wide range of doses has been used for this purpose. In the present study we investigate whether short term
Jeremy Willis et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(26), 10592-10597 (2013-06-12)
The base excision repair pathway is largely responsible for the repair of oxidative stress-induced DNA damage. However, it remains unclear how the DNA damage checkpoint is activated by oxidative stress at the molecular level. Here, we provide evidence showing that
Vladimír Skála et al.
PloS one, 9(11), e111696-e111696 (2014-11-06)
Radix lagotis is an intermediate snail host of the nasal bird schistosome Trichobilharzia regenti. Changes in defence responses in infected snails that might be related to host-parasite compatibility are not known. This study therefore aimed to characterize R. lagotis haemocyte
Miriam H P van Lieshout et al.
PLoS pathogens, 10(9), e1004368-e1004368 (2014-09-26)
Klebsiella pneumoniae is an important cause of sepsis. The common Toll-like receptor adapter myeloid differentiation primary response gene (MyD)88 is crucial for host defense against Klebsiella. Here we investigated the role of MyD88 in myeloid and endothelial cells during Klebsiella
Shirley Medina-Leendertz et al.
Investigacion clinica, 55(4), 352-364 (2015-01-07)
We investigated the effect of melatonin (MEL) in the activities of cytosolic superoxide dismutase (SOD) and catalase as well as in the levels of H2O2 and mitochondrial malondialdehyde (MDA) in paraquat-intoxicated Drosophila melanogaster. Paraquat (40 mM) was administrated for 36
Iraklis Papageorgiou et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 102(7), 1496-1505 (2014-03-08)
Intervertebral total disc replacements (TDR) are used in the treatment of degenerative spinal disc disease. There are, however, concerns that they may be subject to long-term failure due to wear. The adverse effects of TDR wear have the potential to
Pieter Colin et al.
Pharmaceutical research, 31(10), 2876-2886 (2014-05-23)
A strong pharmacokinetic rational exists for the use of (Hyperthermic) Intraperitoneal Perioperative Chemotherapy in peritoneal carcinomatosis. However, controversy remains regarding the optimal treatment strategies. Paclitaxel is believed to be a good compound for IPEC treatment because of its favourable pharmacokinetic
Olivier Morales et al.
British journal of haematology, 166(6), 875-890 (2014-07-22)
Epstein-Barr Virus (EBV) is present in the neoplastic cells of around 20-30% of patients with Hodgkin Lymphoma (HL). Although, an immunosuppressive environment is currently described in HL patients, little is known concerning the regulatory mechanism induced by EBV proteins expression
Dan Li et al.
PloS one, 10(3), e0118284-e0118284 (2015-03-05)
Mammary gland development is controlled by several genes. Although miRNAs have been implicated in mammary gland function, the mechanism by which miR-486 regulates mammary gland development and lactation remains unclear. We investigated miR-486 expression in cow mammary gland using qRT-PCR
Eliisa Ollikainen et al.
Journal of neuropathology and experimental neurology, 73(9), 855-864 (2014-08-08)
Chronic inflammation contributes to remodeling, degeneration, and rupture of saccular intracranial artery aneurysms. Mast cells are important proinflammatory and proangiogenic cells in chronic inflammatory vascular diseases. Here we studied mast cells and neovascularization in 36 intraoperatively resected aneurysms using histology
G L Venturin et al.
Parasite immunology, 37(12), 670-673 (2015-09-27)
Crude total antigen (CTA) from Leishmania infantum and recombinant antigen K39 (rK39) and recombinant antigen K28 (rK28) were compared using an ELISA for the diagnosis of canine visceral leishmaniosis (CVL). Forty-two blood samples from healthy dogs from a nonendemic area
Eun-Jeong Hong et al.
Food microbiology, 53(Pt B), 9-14 (2015-12-19)
The purpose of this study was to inactivate Salmonella Typhimurium on alfalfa seeds without having negative effect on seed germination. Inoculated alfalfa seeds were treated with dry heat at 60, 70 or 80 °C for 0, 12, 18 or 24 h followed
Ensieh Zahmatkesh et al.
Cell journal, 17(3), 569-575 (2015-10-16)
This study aimed to investigate the effects of royal jelly (RJ) on catalase, total antioxidant capacity and embryo development in adult mice treated with oxymetholone (OXM). In this exprimental study, 32 male and 96 female adult Naval Medical Research Institute
Nicolas Pierre et al.
Biochemical and biophysical research communications, 450(1), 459-463 (2014-06-11)
The purpose of this study was to examine the link between oxidative stress and endoplasmic reticulum (ER) stress in myogenic cells. C2C12 myotubes were incubated with hydrogen peroxide (H2O2, 200 μM) and harvested 4h or 17 h after the induction
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