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Dennis J Paustenbach et al.
Clinical toxicology (Philadelphia, Pa.), 52(2), 98-112 (2013-11-22)
INTRODUCTION. There has been some recent concern regarding possible systemic health effects resulting from elevated blood cobalt concentrations in patients with cobalt containing hip implants. To date there are no blood cobalt criteria to help guide physicians when evaluating an
Matej Adámik et al.
Biochemical and biophysical research communications, 456(1), 29-34 (2014-12-03)
Site-specific DNA recognition and binding activity belong to common attributes of all three members of tumor suppressor p53 family proteins: p53, p63 and p73. It was previously shown that heavy metals can affect p53 conformation, sequence-specific binding and suppress p53
G Toncev et al.
European journal of neurology, 9(3), 221-226 (2002-05-03)
Several findings suggest lower levels of serum uric acid in multiple sclerosis (MS) patients. The aim of this study is to investigate relationships of uric acid serum levels in relapse-remitting (RR) MS patients with clinical activity of disease and blood-brain
William T Eckenhoff et al.
Biochimica et biophysica acta, 1827(8-9), 958-973 (2013-05-22)
The generation of H2 from protons and electrons by complexes of cobalt has an extensive history. During the past decade, interest in this subject has increased as a result of developments in hydrogen generation that are driven electrochemically or photochemically.
Chelation in suspected prosthetic hip-associated cobalt toxicity.
Andrea Giampreti et al.
The Canadian journal of cardiology, 30(4), 465-465 (2014-02-13)
Assaf Kadar et al.
The Israel Medical Association journal : IMAJ, 15(9), 505-509 (2013-12-18)
The articular surface replacement (ASR) total hip arthroplasty (THA) was recently recalled from the market due to high failure rates. This modality was used frequently by surgeons at our medical center. To assess the clinical and radiographic outcomes in patients
Leah J Smith et al.
Toxicology and applied pharmacology, 278(3), 259-265 (2014-05-16)
Cobalt exposure is increasing as cobalt demand rises worldwide due to its use in enhancing rechargeable battery efficiency, super-alloys, and magnetic products. Cobalt is considered a possible human carcinogen with the lung being a primary target. However, few studies have
Zhirui Niu et al.
Chemosphere, 109, 92-98 (2014-05-31)
Release of Co and Li from spent lithium ion batteries (LIBs) by bioleaching has attracted growing attentions. However, the pulp density was only 1% or lower, meaning that a huge quantity of media was required for bioleaching. In this work
Heather De Bari et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 69(Pt 3), 228-236 (2013-03-23)
The X-ray crystal structure of ribosome hibernation promoting factor (HPF) from Vibrio cholerae is presented at 2.0 Å resolution. The crystal was phased by two-wavelength MAD using cocrystallized cobalt. The asymmetric unit contained two molecules of HPF linked by four Co
Ming Xu et al.
DNA and cell biology, 33(5), 275-281 (2014-03-13)
Hypoxia and hypoxia-driven angiogenesis play an important role on the recurrence of hepatocellular carcinoma after insufficient radiofrequency ablation. The hypoxia-inducible factor (HIF)-1α/vascular endothelial growth factor-A (VEGFA) pathway plays an important part in this process. Sorafenib is a multikinase inhibitor with
Marta Fort et al.
Environmental research, 136, 148-154 (2014-12-03)
Cobalt is an essential trace element but may cause toxic effects upon occupational or environmental exposure. Women accumulate more cobalt than men at similar exposure levels which may be related to higher metabolic iron loss. During pregnancy these losses are
Yi-Min Wang et al.
Chemosphere, 112, 232-239 (2014-07-23)
Toxicity assessment of Zn-Co mixtures involves multiple ions interactions. The negative potential (ψ0) at the cell membrane surface (CMs) concentrated cationic toxicants (denoted {M(2+)}0) and influenced the rhizotoxicity of Co(2+) or Zn(2+). The single and joint rhizotoxicity of Co(2+) and
Ja Bin Lee et al.
Journal of nanoscience and nanotechnology, 13(11), 7783-7787 (2013-11-20)
We describe the influence of inserted oxygen atoms on the structural and magnetic properties of a [Co/Pt]n multi-layer matrix. The correlation of magnetic properties with oxygen gas flow rate was studied as an alternative perpendicular medium in spin transfer torque
Christopher Jantzen et al.
Acta orthopaedica, 84(3), 229-236 (2013-04-19)
Widely different metal ion concentrations in blood and serum have been reported with metal-on-metal (MoM) implants. We reviewed the literature on blood and serum ion concentrations of chromium (Cr) and cobalt (Co) following various MoM hip arthroplasties. Studies were searched
William L Griffin
The Journal of arthroplasty, 29(4), 659-660 (2014-03-25)
Ion levels have been shown to reliably predict abnormal function of the bearing surface with increased wear, but ion levels should not be used alone as a trigger for when to proceed with revision surgery with metal-metal articulations. Risk stratification
Markus Mandl et al.
Biochemical and biophysical research communications, 434(1), 166-172 (2013-04-02)
Solid tumors include hypoxic areas due to excessive cell proliferation. Adaptation to low oxygen levels is mediated by the hypoxia-inducible factor (HIF) pathway promoting invasion, metastasis, metabolic alterations, chemo-resistance and angiogenesis. The transcription factor HIF-1, the major player within this
A N Fonteh et al.
Amino acids, 32(2), 213-224 (2006-10-13)
Our aim was to determine changes in free amino acid (FAA) and dipeptide (DP) concentrations in probable Alzheimer's disease (pAD) subjects compared with control (CT) subjects using liquid chromatography and electrospray ionization tandem mass spectrometry (LCMS2). We recruited gender- and
Takashi Abe et al.
Neuroscience letters, 336(2), 105-108 (2002-12-25)
In order to investigate the possible role of oxidative RNA damage in the pathogenesis of Parkinson's disease (PD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with
Jacob P Thyssen
Dermatitis : contact, atopic, occupational, drug, 23(5), 203-209 (2012-09-27)
This clinical review article presents clinical and scientific data on cobalt sensitization and dermatitis. It is concluded that cobalt despite being a strong sensitizer and a prevalent contact allergen to come up on patch testing should be regarded as a
Richard Lass et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(9), 1234-1240 (2014-05-21)
Diagnosis of adverse reactions to metal debris in metal-on-metal hip arthroplasty is a multifactorial process. Systemic ion levels are just one factor in the evaluation and should not be relied upon solely to determine the need for revision surgery. Furthermore
S Valanarasu et al.
Journal of nanoscience and nanotechnology, 14(6), 4286-4291 (2014-04-18)
Cobalt Oxide (Co3o4) thin films have been successfully coated onto glass substrates at various solution pH by sol-gel spin coating technique. The film thickness was estimated using weight gain method and it revealed that the film thickness increased with solution
Rima Obeid et al.
Clinical chemistry, 53(6), 1129-1136 (2007-03-27)
Increased plasma total homocysteine (tHcy) is a risk factor for neurological diseases, but the underlying pathophysiology has not been adequately explained. We evaluated concentrations of tHcy, S-adenosyl homocysteine (SAH), S-adenosyl methionine (SAM), folate, and vitamin B(12) in cerebrospinal fluid (CSF)
Douglas A Weigent
Cellular immunology, 282(1), 9-16 (2013-05-04)
We report here that culture of lymphoid cells under hypoxic conditions showed an increase in both luciferase expression from a GH-promoter luciferase construct and the levels of lymphocyte GH. The effect was mimicked by treatment of cells with cobalt chloride
Huseyin Serencam et al.
Acta chimica Slovenica, 60(2), 287-293 (2013-07-25)
A simple and highly sensitive separation and preconcentration procedure, which has minimal impact on the environment, has been developed. The procedure is based on the carrier element free coprecipitation (CEFC) of Co(II), Cu(II), and Ni(II) ions by using 2-{4-[2-(1H-indol-3-yl)ethyl]-3-(4-methylbenzyl)-5-oxo-4,5-dihydro- 1H-1,2,4-triazol-l-yl}-N'-(pyridin-2-yl
Lorale J Lalgee et al.
Biochimica et biophysica acta, 1838(5), 1247-1254 (2014-02-11)
Three amphiphilic cobalt-cage congeners bearing a diaza-crown bridge and varying alkyl chains (1:2:3; n = 12, 16, 18) have been assessed for their ion transport across planar lipid bilayer membranes. In symmetrical electrolyte solutions, a range of ion transport activity
Goran Gajski et al.
Biochimica et biophysica acta, 1840(1), 565-576 (2013-10-22)
The main objective of the present study was to investigate chemical composition and possible cyto/genotoxic potential of several medical implant materials commonly used in total hip joint replacement. Medical implant metal alloy (Ti6Al4V and CoCrMo) and high density polyethylene particles
Marilda Helena Toledo Brandão et al.
Anais brasileiros de dermatologia, 87(2), 269-276 (2012-05-10)
Metals, especially nickel, are the most common contact allergens in children. Recent data has shown increased incidence of allergy in industrialized countries. Sensitization can occur at any age, even in neonates. Costume jewelry, particularly earrings, is linked to increased sensitization
Duy Duc Nguyen et al.
Biochemical and biophysical research communications, 447(1), 101-107 (2014-04-08)
The peptidases in clan MH are known as cocatalytic zinc peptidases that have two zinc ions in the active site, but their metal preference has not been rigorously investigated. In this study, the molecular basis for metal preference is provided
O M Vasyliv et al.
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 75(2), 37-44 (2013-06-01)
Superoxide dismutase, as one of the enzymes of cells' antioxidant defensive system, catalyzes superoxide anion-radical (O2-) dismutation with O2 and H2O2 forming. The influence of such transition metal compounds, as FeSO4, FeCl3, MnCl2, NiCl2, and CoCl2 on superoxide dismutase activity
Ji-Yun Seon et al.
Journal of nanoscience and nanotechnology, 13(11), 7540-7545 (2013-11-20)
A dielectophoretic (DEP) device fabricated by a conventional low temperature co-fired ceramic (LTCC) process, for manipulating micro and nanostructure materials, such as spherical polystyrene microspheres, titanium dioxide (TiO2) nanotubes, and silver (Ag) nanowires, is described. To generate a non-uniform electric
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