356891

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Adverse local tissue reaction arising from corrosion at the femoral neck-body junction in a dual-taper stem with a cobalt-chromium modular neck.

H John Cooper et al.

The Journal of bone and joint surgery. American volume, 95(10), 865-872 (2013-05-17)

Femoral stems with dual-taper modularity were introduced to allow additional options for hip-center restoration independent of femoral fixation in total hip arthroplasty. Despite the increasing availability and use of these femoral stems, concerns exist about potential complications arising from the

Plasma beta-phenylethylamine in Parkinson's disease.

Y Miura

The Kurume medical journal, 47(4), 267-272 (2001-02-24)

Plasma beta-phenylethylamine (PEA) levels were determined in 27 patients with Parkinson's disease (PD) in order to evaluate its relation with the severity or clinical course of PD. The plasma PEA concentrations in PD patients were significantly lower (mean +/- SD

NO and NO2 sensing properties of WO3 and Co3O4 based gas sensors.

Takafumi Akamatsu et al.

Sensors (Basel, Switzerland), 13(9), 12467-12481 (2013-09-21)

Semiconductor-based gas sensors that use n-type WO3 or p-type Co3O4 powder were fabricated and their gas sensing properties toward NO2 or NO (0.5-5 ppm in air) were investigated at 100 °C or 200 °C. The resistance of the WO3-based sensor

Unique ligand-radical character of an activated cobalt salen catalyst that is generated by aerobic oxidation of a cobalt(II) salen complex.

Takuya Kurahashi et al.

Inorganic chemistry, 52(7), 3908-3919 (2013-03-23)

The Co(salen)(X) complex, where salen is chiral N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine and X is an external axial ligand, has been widely utilized as a versatile catalyst. The Co(salen)(X) complex is a stable solid that has been conventionally described as a Co(III)(salen)(X) complex. Recent

Gene expression profiles reveal distinct immunological responses of cobalt and cerium dioxide nanoparticles in two in vitro lung epithelial cell models.

Sandra Verstraelen et al.

Toxicology letters, 228(3), 157-169 (2014-05-14)

Fragmentary knowledge exists on cellular signaling responses underlying possible adverse health effects of CoO- and CeO2-nanoparticles (NP)s after inhalation. We aimed to perform a time kinetic study of gene expression profiles induced by these NPs in alveolar A549 and bronchial

Raised levels of metal ions in the blood in patients who have undergone uncemented metal-on-polyethylene Trident-Accolade total hip replacement.

P Craig et al.

The bone & joint journal, 96-B(1), 43-47 (2014-01-08)

The issues surrounding raised levels of metal ions in the blood following large head metal-on-metal total hip replacement (THR), such as cobalt and chromium, have been well documented. Despite the national popularity of uncemented metal-on-polyethylene (MoP) THR using a large-diameter

Antimicrobial activity of cobalt imidazolate metal-organic frameworks.

Sonia Aguado et al.

Chemosphere, 113, 188-192 (2014-07-30)

Two cobalt imidazolate metal-organic frameworks were evaluated as a bactericidal material against the growth of the Gram-negative bacteria Pseudomonas putida and Escherichia coli. Under the most unfavourable conditions, within the exponential growth phase and in the culture media for both

A review of the health hazards posed by cobalt.

Dennis J Paustenbach et al.

Critical reviews in toxicology, 43(4), 316-362 (2013-05-10)

Cobalt (Co) is an essential element with ubiquitous dietary exposure and possible incremental exposure due to dietary supplements, occupation and medical devices. Adverse health effects, such as cardiomyopathy and vision or hearing impairment, were reported at peak blood Co concentrations

Galvanic replacement reactions in metal oxide nanocrystals.

Myoung Hwan Oh et al.

Science (New York, N.Y.), 340(6135), 964-968 (2013-05-25)

Galvanic replacement reactions provide a simple and versatile route for producing hollow nanostructures with controllable pore structures and compositions. However, these reactions have previously been limited to the chemical transformation of metallic nanostructures. We demonstrated galvanic replacement reactions in metal

Markers of dopamine metabolism in Parkinson's disease. The Parkinson Study Group.

P A LeWitt et al.

Neurology, 42(11), 2111-2117 (1992-11-01)

We used two analytic methods (a multichannel coulometric electrode array with high-performance liquid chromatography, and gas chromatography-mass spectrophotometry) to measure CSF dopamine (DA) and its metabolites in mildly affected, unmedicated subjects with Parkinson's disease (PD). The mean (+/- SD) concentration

Controlled cobalt doping in biogenic magnetite nanoparticles.

J M Byrne et al.

Journal of the Royal Society, Interface, 10(83), 20130134-20130134 (2013-04-19)

Cobalt-doped magnetite (CoxFe3 -xO4) nanoparticles have been produced through the microbial reduction of cobalt-iron oxyhydroxide by the bacterium Geobacter sulfurreducens. The materials produced, as measured by superconducting quantum interference device magnetometry, X-ray magnetic circular dichroism, Mössbauer spectroscopy, etc., show dramatic

Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: evidence for a protective role of acetylcarnitine.

V Calabrese et al.

Neurochemical research, 28(9), 1321-1328 (2003-08-27)

Recent studies suggest that NO and its reactive derivative peroxynitrite are implicated in the pathogenesis of multiple sclerosis (MS). Patients dying with MS demonstrate increased astrocytic inducible nitric oxide synthase activity, as well as increased levels of iNOS mRNA. Peroxynitrite

Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.

Feiran Zhang et al.

Journal of medicinal chemistry, 56(10), 3996-4016 (2013-05-03)

Methionine aminopeptidases (MetAPs), which remove the initiator methionine from nascent peptides, are essential in all organisms. While MetAP2 has been demonstrated to be a therapeutic target for inhibiting angiogenesis in mammals, MetAP1 seems to be vital for cell proliferation. Our

Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression.

Ryota Shizu et al.

Toxicology letters, 219(2), 143-150 (2013-03-27)

Hypoxia inducible factor (HIF) and 5'-AMP-activated protein kinase are often activated under similar physiological conditions. Constitutive androstane receptor (CAR) translocates into the nucleus in accordance with 5'-AMP-activated protein kinase and thus confers transactivation. The aim of the present study was

Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.

S Carbajo-Pescador et al.

British journal of cancer, 109(1), 83-91 (2013-06-13)

Hepatocellular carcinoma (HCC) growth relies on angiogenesis via vascular endothelial growth factor (VEGF) release. Hypoxia within tumour environment leads to intracellular stabilisation of hypoxia inducible factor 1 alpha (Hif1α) and signal transducer and activator of transcription (STAT3). Melatonin induces apoptosis

Chemistry. Abundant metals give precious hydrogenation performance.

R Morris Bullock

Science (New York, N.Y.), 342(6162), 1054-1055 (2013-11-30)

Al3+ ions dependent structural and magnetic properties of Co-Ni nano-alloys.

R H Kadam et al.

Journal of nanoscience and nanotechnology, 14(6), 4101-4107 (2014-04-18)

Ferrite samples with a chemical formula Co0.5Ni0.5Al(x)Fe(2-x)O4 (where x = 0.0, 0.25, 0.5, 0.75 and 1.0) were synthesized by sol-gel auto-combustion method. The synthesized samples were annealed at 600 degrees C for 4 h. An analysis of X-ray diffraction (XRD)

Cobalt intoxication diagnosed with the help of Dr House.

Kirsten Dahms et al.

Lancet (London, England), 383(9916), 574-574 (2014-02-11)

Cell death of dopamine neurons in aging and Parkinson's disease.

M Naoi et al.

Mechanisms of ageing and development, 111(2-3), 175-188 (2000-02-03)

Dopamine neurons in the substantia nigra of human brain are selectively vulnerable and the number decline by aging at 5-10% per decade. Enzymatic and non-enzymatic oxidation of dopamine generates reactive oxygen species, which induces apoptotic cell death in dopamine neurons.

Induction of miR-21-PDCD4 signaling by tungsten carbide-cobalt nanoparticles in JB6 cells involves ROS-mediated MAPK pathways.

Lichao Hou et al.

Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 32(1), 41-51 (2013-06-14)

Tungsten carbide-cobalt (WC-Co) nanoparticle composites have wide applications because of their hardness and toughness. WC-Co was classified as "probably carcinogenic" to humans by the International Agency for Research on Cancer (IARC) in 2003. It is believed that the toxicity and

Clinical features, testing, and management of patients with suspected prosthetic hip-associated cobalt toxicity: a systematic review of cases.

John J Devlin et al.

Journal of medical toxicology : official journal of the American College of Medical Toxicology, 9(4), 405-415 (2013-11-14)

Safety concerns regarding cobalt-containing metal alloy hip prosthetics (Co-HP) have resulted in product recalls, a medical device alert, and issuance of guidance for clinicians. Recently, cases of suspected prosthetic hip-associated cobalt toxicity (PHACT) from Co-HP have been reported. Although little

Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease.

Takashi Abe et al.

Journal of neuroscience research, 70(3), 447-450 (2002-10-23)

To investigate the possible role of oxidative RNA damage in the pathogenesis of Alzheimer's disease (AD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with AD and

The biological occurrence and trafficking of cobalt.

Sachi Okamoto et al.

Metallomics : integrated biometal science, 3(10), 963-970 (2011-08-02)

Cobalt is an essential trace element in both prokaryotes and eukaryotes. Nevertheless, it occurs less frequently in metalloproteins than other transition metals. This low occurrence appears to be due to the metal's low abundance in nature as well as its

Ten-year outcome of serum metal ion levels after primary total hip arthroplasty: a concise follow-up of a previous report*.

Brett R Levine et al.

The Journal of bone and joint surgery. American volume, 95(6), 512-518 (2013-03-22)

We previously reported on the metal ion concentrations of cobalt, chromium, and titanium that were found in the serum of patients three years after they had undergone primary total hip arthroplasty as compared with the concentrations found in the serum

Measurement of immune markers in the serum and cerebrospinal fluid of multiple sclerosis patients during clinical remission.

C E Shaw et al.

Journal of neurology, 242(2), 53-58 (1995-01-01)

Magnetic resonance imaging of multiple sclerosis (MS) patients often shows active inflammatory lesions despite clinical remission. No immunological marker of disease activity has been identified in these patients. Concentrations of neopterin, interleukin-2 (IL-2), soluble interleukin-2 receptor (sIL-2R) and tumour necrosis

Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease.

S Engelborghs et al.

Neurochemical research, 28(8), 1145-1150 (2003-07-02)

To study changes in amino acid metabolism and biogenic amines in Parkinson's disease, we set up a prospective study and measured biogenic amines, their main metabolites, and 22 different amino acids, in cerebrospinal fluid of Parkinson's disease patients (n =

Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia.

K J Bär et al.

Neurobiology of aging, 24(2), 333-338 (2002-12-25)

Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels of pentosidine and N(epsilon)-(carboxymethyl)-lysine (CML) in serum and cerebrospinal fluid (CSF) of

Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients.

Anna Walter et al.

Neurobiology of aging, 25(10), 1299-1303 (2004-10-07)

Experimental and clinical studies give evidence for breakdown of membrane phospholipids during neurodegeneration. In the present study, we measured the levels of glycerophosphocholine (GPCh), phosphocholine (PCh), and choline, that is, water-soluble metabolites of phosphatidylcholine (PtdCho), in human cerebrospinal fluid (CSF).

Inflammatory multiple-sclerosis plaques generate characteristic metabolic profiles in cerebrospinal fluid.

Norbert W Lutz et al.

PloS one, 2(7), e595-e595 (2007-07-06)

Multiple sclerosis (MS), an inflammatory disease of the central nervous system, manifests itself in numerous forms and stages. A number of brain metabolic alterations have been reported for MS patients vs. control subjects. However, metabolite profiles of cerebrospinal fluid (CSF)

Effects of chemically induced hypoxia on in vitro expression of hypoxia inducible factor-lα, vascular endothelial growth factor, aggrecanase-1, and tissue inhibitor of metalloproteinase-3 in rat mandibular condylar chondrocytes.

Huiping Huang et al.

Journal of oral & facial pain and headache, 28(3), 269-276 (2014-07-30)

To examine the expression of hypoxia inducible factor-lα (HIF-1α), vascular endothelial growth factor (VEGF), aggrecanase-1 (ADAMTS-4), and tissue inhibitor of metalloproteinase-3 (TIMP-3) in rat mandibular condylar chondrocytes under hypoxic conditions and examine the relationship of these expressed factors in early

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