搜索范围
450022
应用筛选条件
关键词:'450022'
显示 31-60 #N/A 602 条结果 关于 "450022" 范围 论文
Kristy Swiderski et al.
Human molecular genetics, 23(25), 6697-6711 (2014-08-02)
Mutations in dystrophin lead to Duchenne muscular dystrophy, which is among the most common human genetic disorders. Dystrophin nucleates assembly of the dystrophin-glycoprotein complex (DGC), and a defective DGC disrupts an essential link between the intracellular cytoskeleton and the basal
Suman Rao et al.
PloS one, 10(2), e0117215-e0117215 (2015-02-07)
Cancer cells are characterized by a complex network of interrelated and compensatory signaling driven by multiple kinases that reduce their sensitivity to targeted therapy. Therefore, strategies directed at inhibiting two or more kinases are required to robustly block the growth
Di Xia et al.
Biochimica et biophysica acta, 1852(5), 913-924 (2015-01-07)
Alzheimer's disease is characterized by the accumulation of amyloid-β (Aβ) and Tau in the brain. In mature neurons, Tau is concentrated in the axon and found at lower levels in the dendrite where it is required for targeting Fyn to
Hiroyuki Takahashi et al.
Biochemical and biophysical research communications, 457(4), 532-537 (2015-01-20)
Insulin signaling in the hypothalamus plays an important role in food intake and glucose homeostasis. Hypothalamic neuronal functions are modulated by glial cells; these form an extensive network connecting the neurons and cerebral vasculature, known as the neurovascular unit (NVU).
Sachiko Ito et al.
Scientific reports, 5, 8327-8327 (2015-02-11)
Autophagy is a common physiological function in all eukaryotes. The process is induced by depletion of nutrients including amino acids. GADD34 is expressed following DNA damage, ER stresses and amino acid deprivation. Here, we investigated the effects of GADD34 on
M J Laye et al.
Disease markers, 2015, 806418-806418 (2015-03-31)
High levels of cardiovascular fitness (CRF) and physical activity (PA) are associated with decreased mortality and risk to develop metabolic diseases. The independent contributions of CRF and PA to metabolic disease risk factors are unknown. We tested the hypothesis that
Nina-Naomi Kreis et al.
Oncotarget, 6(9), 6611-6626 (2014-12-09)
The deregulation of Polo-like kinase 1 is inversely linked to the prognosis of patients with diverse human tumors. Targeting Polo-like kinase 1 has been widely considered as one of the most promising strategies for molecular anticancer therapy. While the preclinical
Sergio Wehinger et al.
Biochimica et biophysica acta, 1852(5), 693-708 (2015-01-13)
A considerable body of evidence exists implicating high levels of free saturated fatty acids in beta pancreatic cell death, although the molecular mechanisms and the signaling pathways involved have not been clearly defined. The membrane protein caveolin-1 has long been
Yan Luo et al.
Oncotarget, 6(6), 4286-4298 (2015-03-05)
Current knowledge indicates that the mammalian target of rapamycin (mTOR) functions as two complexes, mTORC1 and mTORC2, regulating cell growth, proliferation, survival, differentiation, and motility. Recently mSin1 has been identified as a critical component of mTORC2, which is essential for
Yunshuang Yue et al.
The Journal of endocrinology, 224(1), 37-47 (2014-10-29)
Bacterial lipopolysaccharide (LPS), also known as endotoxin, induces profound anorexia. However, the LPS-provoked pro-inflammatory signaling cascades and the neural mechanisms underlying the development of anorexia are not clear. Mammalian target of rapamycin (mTOR) is a key regulator of metabolism, cell
Mariola Olkowicz et al.
Talanta, 131, 510-520 (2014-10-05)
Three procedures for the quantification of cardiac troponin T (cTnT) based on liquid chromatography/mass spectrometry (LC/MS) were developed, validated and compared. The procedures were applied to estimate the cTnT content in the hearts of wild type mice C57BL/6J (WT) and
Dayne A Beccano-Kelly et al.
Human molecular genetics, 24(5), 1336-1349 (2014-10-26)
Mutations in leucine-rich repeat kinase 2 (Lrrk2) are the most common genetic cause of Parkinson's disease (PD), a neurodegenerative disorder affecting 1-2% of those >65 years old. The neurophysiology of LRRK2 remains largely elusive, although protein loss suggests a role
Nabile Boukhettala et al.
Journal of aerosol medicine and pulmonary drug delivery, 28(2), 130-136 (2014-07-23)
During mechanical ventilation, different aerosol generators are employed with various interfaces. The objective of this study was to evaluate the performance of a range of spacers, including a new device called Combihaler® designed for connection with both nebulizers and pressurized
Angelika Muchowicz et al.
Biochemical pharmacology, 93(4), 418-427 (2015-01-13)
Thioredoxins (Trx) together with thioredoxin reductases (TrxR) participate in the maintenance of protein thiol homeostasis and play cytoprotective roles in tumor cells. Therefore, thioredoxin-thioredoxin reductase system is considered to be a promising therapeutic target in cancer treatment. We have previously
Takao Susa et al.
Journal of cellular physiology, 230(7), 1594-1606 (2014-12-24)
We previously encountered regulatory processes wherein dihydrotestosterone (DHT) exerted its inhibitory effect on parathyroid hormone-related protein (PTHrP) gene repression through the estrogen receptor (ER)α, but not the androgen receptor (AR), in breast cancer MCF-7 cells. Here, we investigated whether such
Joann M Spinale et al.
Kidney international, 87(3), 564-574 (2014-10-30)
It has been suggested that soluble urokinase receptor (suPAR) is a causative circulating factor for and a biomarker of focal and segmental glomerulosclerosis (FSGS). Here we undertook validation of these assumptions in both mouse and human models. Injection of recombinant
Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells.
Hao-hao Zhang et al.
Acta pharmacologica Sinica, 36(4), 507-516 (2015-01-27)
To study the function and mechanism of bigelovin, a sesquiterpene lactone from the flower of Chinese herb Inula hupehensis, in regulating JAK2/STAT3 signaling and cancer cell growth. HepG2 cells stably transfected with the STAT3-responsive firefly luciferase reporter plasmid (HepG2/STAT3 cells)
Bharat Jaishy et al.
Journal of lipid research, 56(3), 546-561 (2014-12-23)
Autophagy is a catabolic process involved in maintaining energy and organelle homeostasis. The relationship between obesity and the regulation of autophagy is cell type specific. Despite adverse consequences of obesity on cardiac structure and function, the contribution of altered cardiac
Jianying Shen et al.
Pharmacological reports : PR, 67(2), 217-223 (2015-02-26)
Gambogic amide is the first identified small molecular agonist for TrkA receptor. It mimics NGF functions by selectively activating TrkA receptor and preventing neuron death. However, its function different from that of NGF remains unknown. In the current study, we
Michael C Rudolph et al.
Journal of mammary gland biology and neoplasia, 14(4), 381-386 (2009-12-03)
Analysis of genes and proteins involved in lipid biosynthesis in mammary epithelial cells (MECs) is complicated by the presence of adipose tissue in the mammary gland, which may be predominant in whole tissue lysates depending upon developmental stage. We have
Kang Chen et al.
Journal of cellular biochemistry, 116(3), 467-475 (2014-11-02)
Eph receptor (Eph)-ephrin signaling plays an important role in organ development and tissue regeneration. Bidirectional signaling of EphB4-ephrinB2 regulates cardiovascular development. To assess the role of EphB4-ephrinB2 signaling in cardiac lineage development, we utilized two GFP reporter systems in embryonic
Kun-Peng Wang et al.
Molecular medicine reports, 11(2), 1174-1180 (2014-11-06)
Morphine is used to relieve pain in patients with cancer in terminal phases. Dickkopf‑1 (DKK1), a secreted protein, is a negative regulator of the Wnt/β‑catenin signaling pathway. Morphine and DKK1 are associated with tumorigenesis. However, to the best of our
Heba Alshaker et al.
Breast cancer research and treatment, 149(1), 59-67 (2014-12-08)
Obesity is a known risk factor for breast cancer. We have recently identified that adipokine leptin regulates the expression of a proto-oncogenic enzyme sphingosine kinase 1 (SK1). Signal transducer and activator of transcription 3 (STAT3) has been linked to breast
Angela Margarida Costa et al.
Oncotarget, 6(3), 1422-1434 (2015-01-19)
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade extracellular matrix (ECM), thus assisting invasion. Upregulation of MMPs, frequently reported in gliomas, is associated with aggressive behavior. WNK2 is a tumor suppressor gene expressed in normal brain, and silenced by promoter
Sharanya M Kousik et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 432-439 (2014-09-04)
Recently abstinent methamphetamine (Meth) abusers showed neurovascular dysregulation within the striatum. The factors that contribute to this dysregulation and the persistence of these effects are unclear. The current study addressed these knowledge gaps. First, we evaluated the brains of rats
Julien Pelletier et al.
Molecular neurobiology, 51(1), 240-251 (2014-05-29)
Nerve recovery following injury is usually incomplete, leaving functional deficits. Our aim was to investigate the neural changes in pro-angiogenic, pro-inflammatory and apoptotic factors during and after chronic nerve compression (CNC). Nerve function was impaired after CNC and was progressively
Scott C Smith et al.
Nucleic acids research, 42(18), 11517-11527 (2014-09-14)
The Replication Stress Response (RSR) is a signaling network that recognizes challenges to DNA replication and coordinates diverse DNA repair and cell-cycle checkpoint pathways. Gemcitabine is a nucleoside analogue that causes cytotoxicity by inducing DNA replication blocks. Using a synthetic
Tao He et al.
American journal of dentistry, 23 Spec No B, 3B-10B (2011-02-02)
Despite oral health improvements in many geographies, the prevalence of oral concerns, including caries, gingivitis, dentin hypersensitivity, breath malodor, calculus, and extrinsic staining remains unacceptably high across the globe. Dentifrice offers a convenient and accessible vehicle to deliver ingredients--such as
Hitomi Hasegawa et al.
PloS one, 9(12), e116048-e116048 (2014-12-30)
Activating transcription factor 2 (ATF2) and its homolog ATF7 are phosphorylated at Thr-69/Thr-71 and at Thr-51/Thr-53, respectively, by stress-activated MAPKs regulating their transcriptional functions in G1 and S phases. However, little is known about the role of ATF2 and ATF7
Christine Wasinger et al.
British journal of pharmacology, 171(24), 5708-5727 (2014-08-06)
Despite new therapeutic approaches, metastatic melanomas still have a poor prognosis. Statins reduce low-density lipoprotein cholesterol and exert anti-inflammatory and anti-proliferative actions. We have recently shown that simvastatin triggers an apoptotic burst in human metastatic melanoma cells by the synthesis
2/21