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45763
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Seikou Nakamura et al.
Bioorganic & medicinal chemistry, 21(5), 1043-1049 (2013-02-05)
A methanolic extract and its ethyl acetate-soluble fraction from Sri Lankan curry-leaf, the leaves of Murraya koenigii, inhibited melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. Two new carbazole alkaloids, karapinchamines A and B, were isolated from the ethyl acetate-soluble
Kimiko Fukuoka et al.
Biodegradation, 26(5), 359-373 (2015-07-02)
3-Methylindole, also referred to as skatole, is a pollutant of environmental concern due to its persistence, mobility and potential health impacts. Petroleum refining, intensive livestock production and application of biosolids to agricultural lands result in releases of 3-methylindole to the
Woong-Kee Choi et al.
Journal of separation science, 38(11), 1872-1880 (2015-03-27)
A new, rapid, and sensitive liquid chromatography with tandem mass spectrometry method was developed for the determination of vitisin B and validated in rat plasma and urine using carbamazepine as an internal standard. The plasma (0.05 mL) or urine (0.2
Mitja Križman et al.
Journal of chromatography. A, 1405, 149-155 (2015-06-24)
The recently developed comprehensive TLC×GC technique using headspace sampling is presented. The main advantage of this approach, as demonstrated in lipid analysis, is the possibility to include a transesterification step of glycerides into fatty acid methyl ester derivatives (FAME) because
Jicheng Gong et al.
Environment international, 85, 104-110 (2015-09-19)
1-Nitro-pyrene has been considered a compound specific to diesel combustion emission, while 1- and 2-nitro-napthalene are mainly produced through photochemical conversion of naphthalene released to the atmosphere. Metabolites of these compounds may serve as biomarkers of exposure to traffic related
Paula Arbeláez et al.
Journal of chromatography. A, 1393, 106-114 (2015-04-05)
High-intensity sweeteners have been suggested as potential organic contaminants due to their widespread use in food, drugs and sanitary products. As a consequence, they are introduced into the environment by different pathways, affecting aquatic life. In this study, a method
Johannes Goll et al.
Journal of chromatography. A, 1284, 59-68 (2013-03-08)
Sequential centrifugal partition chromatography (sCPC) is a cyclic solid support-free liquid-liquid chromatographic process, in which a continuously introduced feed mixture is separated into two sequentially collected product streams. The few experimental demonstrations of this concept already revealed its potential for
Martina Kovarova et al.
PLoS pathogens, 11(8), e1005075-e1005075 (2015-08-14)
Vaginal HIV transmission accounts for the majority of new infections worldwide. Currently, multiple efforts to prevent HIV transmission are based on pre-exposure prophylaxis with various antiretroviral drugs. Here, we describe two novel nanoformulations of the reverse transcriptase inhibitor rilpivirine for
Juan Xu et al.
Food chemistry, 187, 75-81 (2015-05-16)
Due to the furanocoumarin compounds in the fruit, the production and consumption of grapefruit have been affected in the past decades since the 'grapefruit juice effect' was declared. To provide elite germplasm and obtain knowledge for future citrus breeding programs
Shuangshuang Ding et al.
Environmental science and pollution research international, 22(21), 17171-17181 (2015-07-04)
The objectives of this work are to track the contamination levels, distribution characteristics, and sources of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in atmospheric particulate matter (APM) of Northern China and to provide more comprehensive and fundamental data for
Benjamin A Ayil-Gutiérrez et al.
Natural product communications, 10(11), 1955-1958 (2016-01-12)
The biological activity of Ruta graveolens leaf tissue extracts obtained with different solvents (ethyl acetate, ethanol, and water) and metabolites (psoralen, 2- undecanone and rutin) against Spodoptera frugiperda was evaluated. Metabolites levels in extracts were quantified by HPLC and GC.
Solomon Matongo et al.
Chemosphere, 134, 133-140 (2015-05-04)
The little data about pharmaceutical residue contamination in African water bodies motivated our study on the occurrence of pharmaceutical residues in the water and sediment of Msunduzi River in the KwaZulu-Natal province of South Africa; and in the Darvill wastewater
Solomon Matongo et al.
Environmental science and pollution research international, 22(13), 10298-10308 (2015-02-25)
Selected pharmaceuticals including antibiotics, antipyretics, a stimulant, an antiepileptic and an antipsychotic drug were determined in wastewater, surface water and sediment along the Umgeni River which is the main source of water to Durban City in KwaZulu-Natal, South Africa. Samples
Christopher A Lear et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(4), R387-R395 (2014-06-20)
Perinatal exposure to infection is highly associated with adverse outcomes. Experimentally, acute, severe exposure to gram-negative bacterial lipopolysaccharide (LPS) is associated with increased fetal heart rate variability (FHRV). It is unknown whether FHRV is affected by subclinical infection with or
Lene H Petersen et al.
Environmental toxicology and chemistry, 34(2), 379-390 (2014-12-04)
As knowledge of contaminants capable of adversely modulating endocrine functions increases, attention is focused on the effects of synthetic progestins as environmental endocrine disrupters. In the present study, effects of exposure to a synthetic progestin (norethindrone, 168 ± 7.5 ng/L) and endogenous progestogen
Shuai Wang et al.
Nanoscale, 7(42), 17848-17854 (2015-10-16)
In this paper, nanotubes with a uniform diameter were prepared by self-assembly of an achiral azobenzene-containing fatty acid. The polymorphic transformation of the assemblies during the cooling process was systematically studied. By controlling the incubation temperature, different morphologies, such as
L Amaya-Delgado et al.
World journal of microbiology & biotechnology, 29(5), 875-881 (2013-01-19)
Traditionally, industrial tequila production has used spontaneous fermentation or Saccharomyces cerevisiae yeast strains. Despite the potential of non-Saccharomyces strains for alcoholic fermentation, few studies have been performed at industrial level with these yeasts. Therefore, in this work, Agave tequilana juice
Stephanie L Wright et al.
Scientific reports, 5, 14119-14119 (2015-09-16)
Marine debris is a global environmental issue. Smoked cigarette filters are the predominant coastal litter item; 4.5 trillion are littered annually, presenting a source of bioplastic microfibres (cellulose acetate) and harmful toxicants to marine environments. Despite the human health risks
Veronika Cakova et al.
Journal of separation science, 38(17), 3006-3013 (2015-06-25)
Vandaterosides are polar glucosyloxybenzyl eucomate derivatives found in Vanda teres (Orchidaceae), which display biological activities that slow the skin ageing process. In order to obtain larger quantities to allow us to go further in the bioassays, the hydroalcoholic extract of
Hao Dong et al.
Journal of chromatography. A, 1422, 82-88 (2015-11-01)
A sensitive gas chromatography-mass spectrometry method was established for the simultaneous determination of thirteen N-nitrosamines (NAs) in skin care cosmetics. The cosmetics samples were firstly dispersed by water and subsequently extracted and purified using salting out-acetonitrile homogeneous extraction method. Finally
Kathy S Xue et al.
Scientific reports, 5, 17545-17545 (2015-12-03)
Green tea polyphenols (GTP) are highly effective in inhibiting a variety of tumorigenic effects induced by carcinogens. In this study we assessed GTP mitigation on biomarkers of fumonisin B1 (FB1), a class 2B carcinogen, in blood and urine samples collected
Helen L Barr et al.
The European respiratory journal, 46(4), 1046-1054 (2015-05-30)
Pseudomonas aeruginosa produces quorum sensing signal molecules that are potential biomarkers for infection.A prospective study of 60 cystic fibrosis patients with chronic P. aeruginosa, who required intravenous antibiotics for pulmonary exacerbations, was undertaken. Clinical measurements and biological samples were obtained
Elena Zanni et al.
Research in microbiology, 166(2), 84-92 (2015-01-13)
In Kluyveromyces lactis yeast, OCH1 encodes for the α-1,6-mannosyltrasferase that adds the initial α-1,6-mannose to the outer-chains of N-glycoproteins. Kloch1-1 mutant cells showed altered calcium homeostasis and endoplasmic reticulum (ER) stress. Since ER plays a major role in lipid biosynthesis
Siân Marsden-Jones et al.
Journal of chromatography. A, 1398, 66-72 (2015-05-02)
Countercurrent chromatography (CCC) is a form of liquid-liquid chromatography. It works by running one immiscible solvent (mobile phase) over another solvent (stationary phase) being held in a CCC column using centrifugal force. The concentration of compound in each phase is
Zhen-Feng Chen et al.
Journal of medicinal chemistry, 58(5), 2159-2179 (2015-02-05)
Two G-quadruplex ligands [Pt(L(a))(DMSO)Cl] (Pt1) and [Pt(L(b))(DMSO)Cl] (Pt2) have been synthesized and fully characterized. The two complexes are more selective for SK-OV-3/DDP tumor cells versus normal cells (HL-7702). It was found that both Pt1 and Pt2 could be a telomerase
Amy M Worthington et al.
The Journal of experimental biology, 218(Pt 17), 2720-2727 (2015-06-27)
Direct benefits are considered to be the driving force of high female mating rates, yet species in which females do not receive material resources from males still experience increased fitness from mating frequently. One hypothesis suggests that substances within the
Naiyu Zheng et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 988, 66-74 (2015-03-10)
Apixaban (Eliquis™) was developed by Bristol-Myers Squibb (BMS) and Pfizer to use as an antithrombotic/anticoagulant agent and has been recently approved for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. A clinical study of apixaban
Mylène Ratelle et al.
Toxicology letters, 232(2), 369-375 (2014-12-17)
Permethrin is a widely used pyrethroid insecticide for which the toxicokinetics of exposure biomarkers in humans is not fully documented. The time courses of key biomarkers of permethrin exposure were thus assessed in accessible biological matrices of orally exposed volunteers.
Tereza Lundová et al.
Chemico-biological interactions, 234, 178-187 (2014-12-03)
Dehydrogenase/reductase (SDR family) member 3 (DHRS3), also known as retinal short-chain dehydrogenase/reductase (retSDR1) is a member of SDR16C family. This family is thought to be NADP(H) dependent and to have multiple substrates; however, to date, only all-trans-retinal has been identified
Jacqueline Ferris et al.
Cytogenetic and genome research, 145(1), 50-58 (2015-04-15)
Bisphenol A (BPA) exposure in humans is widespread, and BPA has been detected in a variety of samples including follicular fluid. BPA levels have been found to negatively correlate with the developmental potential of oocytes in women undergoing in vitro
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