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48877
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关键词:'48877'
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Shintaro Tsuka et al.
Biochemical and biophysical research communications, 459(3), 437-442 (2015-03-05)
A close relationship between the bone and systemic glucose metabolism has recently been the center of attention, since the uncarboxylated form of osteocalcin (GluOC), a bone-derived protein, but not the γ-carboxylated form, is involved in glucose metabolism. However, the analysis
Lore Lapeire et al.
Cancer research, 74(23), 6806-6819 (2014-09-26)
Increasing evidence supports the critical roles played by adipose tissue in breast cancer progression. Yet, the mediators and mechanisms are poorly understood. Here, we show that breast cancer-associated adipose tissue from freshly isolated tumors promotes F-actin remodeling, cellular scattering, invasiveness
W G Brydon et al.
European journal of gastroenterology & hepatology, 8(2), 117-123 (1996-02-01)
To assess the reliability of serum 7 alpha-hydroxy-4-cholesten-3-one (7 alpha-3ox-C) in the differential diagnosis of bile acid induced diarrhoea by comparison with 75selenohomocholyltaurine whole body retention (SeHCAT WBR). One hundred and sixty-four patients with chronic diarrhoea were investigated prospectively in
Kyung-Min Lee et al.
Cellular signalling, 27(2), 228-235 (2014-12-03)
The Warburg effect is an oncogenic metabolic switch that allows cancer cells to take up more glucose than normal cells and favors anaerobic glycolysis. Extracellular matrix protein 1 (ECM1) is a secreted glycoprotein that is overexpressed in various types of
Chao Long et al.
Journal of hazardous materials, 203-204, 251-256 (2011-12-30)
A novel hypercrosslinked polymeric adsorbent (HY-1) with high surface area and specific bimodal pore size distribution in the regions of micropore (0.5-2.0 nm) and meso-macropore (30-70 nm) was prepared. Adsorption properties of benzene and methyl ethyl ketone (MEK) vapors onto
Caroline Rosier et al.
Applied and environmental microbiology, 78(12), 4516-4518 (2012-04-12)
Acetone carboxylase (Acx) is a key enzyme involved in the biodegradation of acetone by bacteria. Except for the Helicobacteraceae family, genome analyses revealed that bacteria that possess an Acx, such as Cupriavidus metallidurans strain CH34, are associated with soil. The
Kuei-Yang Hsiao et al.
Human reproduction (Oxford, England), 29(12), 2747-2755 (2014-10-16)
How does hypoxia-mediated down-regulation of dual specificity phosphatase-2 (DUSP2) promote endometriotic lesion development? Inhibition of DUSP2 by hypoxia enhances endometriotic lesion growth via promoting interleukin-8 (IL-8)-dependent angiogenesis. Angiogenesis is a prerequisite for the development of endometriosis. DUSP2 is down-regulated in
Xingbo Xu et al.
Cardiovascular research, 105(3), 279-291 (2015-01-27)
Methylation of CpG island promoters is a prototypical epigenetic mechanism to stably control gene expression. The aim of this study was to elucidate the contribution of aberrant promoter DNA methylation in pathological endothelial to mesenchymal transition (EndMT) and subsequent cardiac
Hyun Young Jeong et al.
Molecular and cellular biochemistry, 410(1-2), 247-254 (2015-09-12)
Obesity is a serious medical condition causing various diseases such as heart disease, type-2 diabetes, and cancer. Fat cells (adipocytes) play an important role in the generation of energy through hydrolysis of lipids they accumulate. Therefore, induction of lipolysis (breakdown
Chun-Han Hou et al.
Molecular cancer, 13, 236-236 (2014-10-20)
Osteosarcoma is the most common primary malignant tumor in children and young adults, and its treatment requires effective therapeutic approaches because of a high mortality rate for lung metastasis. Epithelial to mesenchymal transition (EMT) has received considerable attention as a
Yong Pan et al.
Oncotarget, 6(36), 38816-38826 (2015-10-10)
The purpose of this study was to identify the role COX-2 plays in K-ras-induced lung carcinogenesis. We crossed COX-2-homozygous knockout mice with K-rasLA1 (G12D) expressing mice to obtain COX-2-deficient mice with K-ras expression (K-ras/COX-2(-/-) mice) and COX-2 wild type mice
E Askari et al.
Journal of the mechanical behavior of biomedical materials, 12, 144-150 (2012-06-27)
This study describes the synthesis of Al(2)O(3)/SiC/ZrO(2) functionally graded material (FGM) in bio-implants (artificial joints) by electrophoretic deposition (EPD). A suitable suspension that was based on 2-butanone was applied for the EPD of Al(2)O(3)/SiC/ZrO(2), and a pressureless sintering process was
Makoto Wada et al.
PloS one, 9(11), e113217-e113217 (2014-11-26)
Although melanoma is the most aggressive skin cancer, recent advances in BRAF and/or MEK inhibitors against BRAF-mutated melanoma have improved survival rates. Despite these advances, a treatment strategy targeting NRAS-mutated melanoma has not yet been elucidated. We discovered CH5126766/RO5126766 as
Richard J Bodnar et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 23(6), 785-796 (2015-07-25)
Pericytes are mural cell that have been found to play important roles in promoting blood vessel development and regulating blood flow. The signals that attract pericytes to maturing vessels during the resolution phase of wound healing are unknown. In this
Hao Yang et al.
Oncotarget, 5(18), 8188-8201 (2014-08-26)
Wogonin, a flavonoid derived from Scutellaria baicalensis Georgi, has been demonstrated to be highly effective in treating hematologic malignancies. In this study, we investigated the anticancer effects of wogonin on K562 cells, K562 imatinib-resistant cells, and primary patient-derived CML cells.
Jinghui Yang et al.
Biochemical and biophysical research communications, 467(4), 704-710 (2015-10-27)
The autophagy pathway has previously been suggested as an important protective factor in liver injury. The purpose of this study is to demonstrate the protective, autophagy-modulating effect of tri-iodothyronine (T3) on liver ischemia reperfusion injury. Liver ischemia reperfusion was induced
Isha Dhande et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 38(1), 21-29 (2014-09-12)
Macrophages have an important role in the pathogenesis of hypertension and associated end-organ damage via the activation of the Toll-like receptors, such as Toll-like receptor-4 (TLR4). Accumulating evidence suggests that the angiotensin AT2 receptor (AT2R) has a protective role in
Lindsay C Stetson et al.
BMC genomics, 15 Suppl 7, S2-S2 (2015-01-13)
A challenge in precision medicine is the transformation of genomic data into knowledge that can be used to stratify patients into treatment groups based on predicted clinical response. Although clinical trials remain the only way to truly measure drug toxicities
Wonjae Cha et al.
Anticancer research, 35(4), 2049-2054 (2015-04-12)
Despite an excellent prognosis, certain patients with thyroid cancer suffer from locally invasive disease that cannot be controlled by conventional therapy. Our previous study suggested that hypoxia inducible factor-1-alpha (HIF1α) might be an important marker for the identification of and
Hyun-Ji Park et al.
Biomaterials, 50, 127-139 (2015-03-05)
Current protocols for human pluripotent stem cell (hPSC) expansion require feeder cells or matrices from animal sources that have been the major obstacle to obtain clinical grade hPSCs due to safety issues, difficulty in quality control, and high expense. Thus
Ting Chen et al.
Cancer biology & therapy, 16(1), 106-114 (2014-12-09)
Multidrug resistance (MDR) is one of the major obstacles to the efficiency of cancer chemotherapy, which often results from the overexpression of drug efflux transporters such as P-glycoprotein (P-gp). In the present study, we determined the effect of dasatinib which
Chien-Kuo Han et al.
The American journal of Chinese medicine, 42(6), 1507-1519 (2014-12-09)
Infusion of high-KCl cardioplegic solution (High-KCS) is the most common method used to induce asystole before cardiac surgery. However, our previous study showed the High-KCS can cause the apoptosis of cardiomyocytes in patients who were administered High-KCS prior to undergoing
Yucui Hou et al.
The journal of physical chemistry. B, 118(47), 13646-13650 (2014-10-30)
Because of similar properties and very low volatility, isomers of benzene poly(carboxylic acid)s (BPCAs) are very difficult to separate. In this work, we found that isomers of BPCAs could be separated efficiently by quaternary ammonium salts (QASs) via formation of
Yi-Te Lin et al.
Biochemical pharmacology, 93(1), 110-124 (2014-12-03)
Prothymosin alpha (PTMA) is overexpressed in various human tumors, including hepatocellular carcinoma (HCC). The significance of PTMA overexpression and its underlying mechanism remain unclear. We show here that silencing PTMA sensitizes HCC cells to the kinase inhibitor sorafenib. In contrast
Nora V Lieske et al.
PloS one, 10(11), e0141903-e0141903 (2015-11-07)
Human regulatory T cells (Tregs) are essential in maintaining immunological tolerance and suppress effector T cells. Tregs are commonly up-regulated in chronic infectious diseases such as tuberculosis (TB) and human immunodeficiency virus (HIV) infection and thereby hamper disease-specific immune responses
Chunshu Piao et al.
Experimental neurology, 273, 288-300 (2015-09-24)
Astrocyte glutamate transporters GLAST and GLT1 play a key role in regulating neuronal excitation and their levels are altered in patients with epilepsy, and after traumatic brain injury. The mechanisms which regulate their expression are not well understood. We tested
Taisuke Yoshimoto et al.
Biochemical and biophysical research communications, 455(3-4), 251-255 (2014-12-03)
Vinculin regulates a variety of cellular functions partly through stabilization of tumor suppressor PTEN. In order to study the role of vinculin in tumor progression other than PTEN stabilization, vinculin was knocked down in PTEN-deficient squamous cell carcinoma HSC-4 cells.
Mohammad Fallahi-Sichani et al.
Molecular systems biology, 11(3), 797-797 (2015-03-31)
Drugs that inhibit RAF/MEK signaling, such as vemurafenib, elicit profound but often temporary anti-tumor responses in patients with BRAF(V) (600E) melanoma. Adaptive responses to RAF/MEK inhibition occur on a timescale of hours to days, involve homeostatic responses that reactivate MAP
Rosita Kantola et al.
The International journal of prosthodontics, 24(6), 582-588 (2011-12-08)
Recently, fiber-reinforced composite resin (FRC) has been introduced as a framework material for maxillofacial silicone prostheses. The purpose of this research was to study the tensile bond strength between a room temperature-polymerized maxillofacial silicone elastomer and a unidirectional FRC. Three
Chen-Yu Wang et al.
Molecular and cellular biology, 35(10), 1712-1726 (2015-03-11)
Growth-associated protein 43 (GAP43) is known to regulate axon growth, but whether it also plays a role in synaptogenesis remains unclear. Here, we found that GAP43 regulates the aggregation of gephyrin, a pivotal protein for clustering postsynaptic GABA(A) receptors (GABA(A)Rs)
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