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Rosita Kantola et al.
The International journal of prosthodontics, 24(6), 582-588 (2011-12-08)
Recently, fiber-reinforced composite resin (FRC) has been introduced as a framework material for maxillofacial silicone prostheses. The purpose of this research was to study the tensile bond strength between a room temperature-polymerized maxillofacial silicone elastomer and a unidirectional FRC. Three
Hyun-Ji Park et al.
Biomaterials, 50, 127-139 (2015-03-05)
Current protocols for human pluripotent stem cell (hPSC) expansion require feeder cells or matrices from animal sources that have been the major obstacle to obtain clinical grade hPSCs due to safety issues, difficulty in quality control, and high expense. Thus
Ting Chen et al.
Cancer biology & therapy, 16(1), 106-114 (2014-12-09)
Multidrug resistance (MDR) is one of the major obstacles to the efficiency of cancer chemotherapy, which often results from the overexpression of drug efflux transporters such as P-glycoprotein (P-gp). In the present study, we determined the effect of dasatinib which
Chien-Kuo Han et al.
The American journal of Chinese medicine, 42(6), 1507-1519 (2014-12-09)
Infusion of high-KCl cardioplegic solution (High-KCS) is the most common method used to induce asystole before cardiac surgery. However, our previous study showed the High-KCS can cause the apoptosis of cardiomyocytes in patients who were administered High-KCS prior to undergoing
Wonjae Cha et al.
Anticancer research, 35(4), 2049-2054 (2015-04-12)
Despite an excellent prognosis, certain patients with thyroid cancer suffer from locally invasive disease that cannot be controlled by conventional therapy. Our previous study suggested that hypoxia inducible factor-1-alpha (HIF1α) might be an important marker for the identification of and
Mohammad Fallahi-Sichani et al.
Molecular systems biology, 11(3), 797-797 (2015-03-31)
Drugs that inhibit RAF/MEK signaling, such as vemurafenib, elicit profound but often temporary anti-tumor responses in patients with BRAF(V) (600E) melanoma. Adaptive responses to RAF/MEK inhibition occur on a timescale of hours to days, involve homeostatic responses that reactivate MAP
Nadja Graf et al.
Applied microbiology and biotechnology, 97(18), 8239-8251 (2013-06-19)
A methyl ethyl ketone (MEK)-inducible system based on the broad-host-range plasmid pBBR1MCS2 and on the P mekA promoter region of the MEK degradation operon of Pseudomonas veronii MEK700 was characterized in Escherichia coli JM109 and Pseudomonas putida KT2440. For validation
Richard J Bodnar et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 23(6), 785-796 (2015-07-25)
Pericytes are mural cell that have been found to play important roles in promoting blood vessel development and regulating blood flow. The signals that attract pericytes to maturing vessels during the resolution phase of wound healing are unknown. In this
Lindsay C Stetson et al.
BMC genomics, 15 Suppl 7, S2-S2 (2015-01-13)
A challenge in precision medicine is the transformation of genomic data into knowledge that can be used to stratify patients into treatment groups based on predicted clinical response. Although clinical trials remain the only way to truly measure drug toxicities
Chi-Chiu Lee et al.
Journal of applied toxicology : JAT, 35(4), 407-417 (2014-07-23)
This study reports on a cytotoxic toxin derived from the venom of the crown-of-thorns starfish Acanthaster planci (CAV). The protein toxin was isolated through both ion-exchange and gel-filtration chromatography, and characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and mass
Guosong Li et al.
Medical oncology (Northwood, London, England), 32(2), 478-478 (2015-01-06)
In recent decades, the CXC chemokine receptor 7 (CCR7) [corrected] and its ligand CCL21 have been extensively reported to be associated with tumorigenesis. Meanwhile, Slug signaling induces the epithelial-mesenchymal transition (EMT) process in chondrosarcoma development. In the present study, we
Maria Beatrice Morelli et al.
BMC cancer, 14, 921-921 (2014-12-08)
There is evidence that calcium (Ca(2+)) increases the proliferation of human advanced prostate cancer (PCa) cells but the ion channels involved are not fully understood. Here, we investigated the correlation between alpha(1D)-adrenergic receptor (alpha(1D)-AR) and the transient receptor potential vanilloid
Shintaro Tsuka et al.
Biochemical and biophysical research communications, 459(3), 437-442 (2015-03-05)
A close relationship between the bone and systemic glucose metabolism has recently been the center of attention, since the uncarboxylated form of osteocalcin (GluOC), a bone-derived protein, but not the γ-carboxylated form, is involved in glucose metabolism. However, the analysis
Teppei Sugano et al.
Molecular cancer therapeutics, 14(11), 2433-2440 (2015-09-10)
Patients with non-small cell lung cancer (NSCLC) EGFR mutations have shown a dramatic response to EGFR inhibitors (EGFR-TKI). EGFR T790M mutation and MET amplification have been recognized as major mechanisms of acquired resistance to EGFR-TKI. Therefore, MET inhibitors have recently
Yucui Hou et al.
The journal of physical chemistry. B, 118(47), 13646-13650 (2014-10-30)
Because of similar properties and very low volatility, isomers of benzene poly(carboxylic acid)s (BPCAs) are very difficult to separate. In this work, we found that isomers of BPCAs could be separated efficiently by quaternary ammonium salts (QASs) via formation of
Kuei-Yang Hsiao et al.
Human reproduction (Oxford, England), 29(12), 2747-2755 (2014-10-16)
How does hypoxia-mediated down-regulation of dual specificity phosphatase-2 (DUSP2) promote endometriotic lesion development? Inhibition of DUSP2 by hypoxia enhances endometriotic lesion growth via promoting interleukin-8 (IL-8)-dependent angiogenesis. Angiogenesis is a prerequisite for the development of endometriosis. DUSP2 is down-regulated in
Xingbo Xu et al.
Cardiovascular research, 105(3), 279-291 (2015-01-27)
Methylation of CpG island promoters is a prototypical epigenetic mechanism to stably control gene expression. The aim of this study was to elucidate the contribution of aberrant promoter DNA methylation in pathological endothelial to mesenchymal transition (EndMT) and subsequent cardiac
W G Brydon et al.
European journal of gastroenterology & hepatology, 8(2), 117-123 (1996-02-01)
To assess the reliability of serum 7 alpha-hydroxy-4-cholesten-3-one (7 alpha-3ox-C) in the differential diagnosis of bile acid induced diarrhoea by comparison with 75selenohomocholyltaurine whole body retention (SeHCAT WBR). One hundred and sixty-four patients with chronic diarrhoea were investigated prospectively in
M Schmitt et al.
Cell death and differentiation, 22(4), 677-689 (2014-10-11)
Wnt reception at the membrane is complex and not fully understood. CD44 is a major Wnt target gene in the intestine and is essential for Wnt-induced tumor progression in colorectal cancer. Here we show that CD44 acts as a positive
Wolfgang Baether et al.
The Analyst, 137(11), 2723-2727 (2012-04-27)
Ion mobility spectrometry (IMS) is well known for its very high sensitivity, and thus IMS spectra are commonly used in the identification of trace gases. Extracting quantitative information from IMS spectra is, in contrast, difficult, especially regarding the reproducibility due
Hyun Young Jeong et al.
Molecular and cellular biochemistry, 410(1-2), 247-254 (2015-09-12)
Obesity is a serious medical condition causing various diseases such as heart disease, type-2 diabetes, and cancer. Fat cells (adipocytes) play an important role in the generation of energy through hydrolysis of lipids they accumulate. Therefore, induction of lipolysis (breakdown
Makoto Wada et al.
PloS one, 9(11), e113217-e113217 (2014-11-26)
Although melanoma is the most aggressive skin cancer, recent advances in BRAF and/or MEK inhibitors against BRAF-mutated melanoma have improved survival rates. Despite these advances, a treatment strategy targeting NRAS-mutated melanoma has not yet been elucidated. We discovered CH5126766/RO5126766 as
E Askari et al.
Journal of the mechanical behavior of biomedical materials, 12, 144-150 (2012-06-27)
This study describes the synthesis of Al(2)O(3)/SiC/ZrO(2) functionally graded material (FGM) in bio-implants (artificial joints) by electrophoretic deposition (EPD). A suitable suspension that was based on 2-butanone was applied for the EPD of Al(2)O(3)/SiC/ZrO(2), and a pressureless sintering process was
Chao Long et al.
Journal of hazardous materials, 203-204, 251-256 (2011-12-30)
A novel hypercrosslinked polymeric adsorbent (HY-1) with high surface area and specific bimodal pore size distribution in the regions of micropore (0.5-2.0 nm) and meso-macropore (30-70 nm) was prepared. Adsorption properties of benzene and methyl ethyl ketone (MEK) vapors onto
Caroline Rosier et al.
Applied and environmental microbiology, 78(12), 4516-4518 (2012-04-12)
Acetone carboxylase (Acx) is a key enzyme involved in the biodegradation of acetone by bacteria. Except for the Helicobacteraceae family, genome analyses revealed that bacteria that possess an Acx, such as Cupriavidus metallidurans strain CH34, are associated with soil. The
Hao Yang et al.
Oncotarget, 5(18), 8188-8201 (2014-08-26)
Wogonin, a flavonoid derived from Scutellaria baicalensis Georgi, has been demonstrated to be highly effective in treating hematologic malignancies. In this study, we investigated the anticancer effects of wogonin on K562 cells, K562 imatinib-resistant cells, and primary patient-derived CML cells.
Kyung-Min Lee et al.
Cellular signalling, 27(2), 228-235 (2014-12-03)
The Warburg effect is an oncogenic metabolic switch that allows cancer cells to take up more glucose than normal cells and favors anaerobic glycolysis. Extracellular matrix protein 1 (ECM1) is a secreted glycoprotein that is overexpressed in various types of
Isha Dhande et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 38(1), 21-29 (2014-09-12)
Macrophages have an important role in the pathogenesis of hypertension and associated end-organ damage via the activation of the Toll-like receptors, such as Toll-like receptor-4 (TLR4). Accumulating evidence suggests that the angiotensin AT2 receptor (AT2R) has a protective role in
Jinghui Yang et al.
Biochemical and biophysical research communications, 467(4), 704-710 (2015-10-27)
The autophagy pathway has previously been suggested as an important protective factor in liver injury. The purpose of this study is to demonstrate the protective, autophagy-modulating effect of tri-iodothyronine (T3) on liver ischemia reperfusion injury. Liver ischemia reperfusion was induced
Angela Kolodziej et al.
NeuroImage, 103, 171-180 (2014-09-23)
Electrical and optogenetic methods for brain stimulation are widely used in rodents for manipulating behavior and analyzing functional connectivities in neuronal circuits. High-resolution in vivo imaging of the global, brain-wide, activation patterns induced by these stimulations has remained challenging, in
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