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Nadem Soufir et al.
The Journal of investigative dermatology, 130(6), 1537-1542 (2010-01-08)
Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder that is associated with an inherited defect of the nucleotide excision repair pathway (NER). In this study, we investigated the involvement of XP genes in 86 XP patients belonging to 66
Ze-Hua Wang et al.
Asian Pacific journal of cancer prevention : APJCP, 12(8), 1973-1977 (2012-02-02)
Human arrest defective 1 protein (ARD1), as a N-terminal acetyltransferase, has been reported to play a crucial role in tumorigenesis, but the results are somewhat controversial. To explore the clinical and pathological significance of ARD1 in breast tumorigenesis, we analyzed
Ruo-Zhi Zhao et al.
Biochemical and biophysical research communications, 327(4), 985-992 (2005-01-18)
We investigated the effect of TNF-alpha on interleukin-8 (IL-8) and endothelin-1 (ET-1) expression, and their different signal transduction pathways. Human dermal microvascular endothelial cells (HMECs) were treated with TNF-alpha. By Northern blot analysis, TNF-alpha at 50, 100, 200, and 400
Hao Wu et al.
Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology, 20(6), 249-250 (2006-06-03)
To investigate the expression of fragile histidine triad gene protein (Fhit) and the possible relationship between Fhit and biological behaviors of hypopharyngeal carcinoma. The expression of Fhit protein in 66 cases with hypopharyngeal carcinoma were detected by rabbit antibody to
Yue Huang et al.
International journal of ophthalmology, 12(3), 369-374 (2019-03-29)
To explore the protective effect of zeaxanthin on human limbal and conjunctival epithelial cells against UV-radiation and excessive oxidative stress. Human limbal and conjunctival epithelial cells were isolated from cadaver and cultured in vitro. They were challenged with UVB radiation
F Giangaspero et al.
Applied pathology, 7(2), 134-144 (1989-01-01)
An immunocytochemical study using a panel of commercially available antisera, has been performed to distinguish on the basis of their immunoreactivity a series of spindle cell sarcomas diagnosed solely on the histologic features: 11 malignant schwannomas (MS), 8 leiomyosarcomas (LMS)
R Bruce David et al.
Molecular and cellular endocrinology, 188(1-2), 207-218 (2002-03-26)
A partial cDNA of the sheep erythropoietin receptor (EpoR) was obtained and used in real-time PCR to quantitate mRNA levels in placenta, liver and kidney throughout development (term=150 days). This was compared with Epo mRNA levels in the same tissues.
Kiruthiga Perumal Vijayaraman et al.
Asian Pacific journal of cancer prevention : APJCP, 13(2), 511-516 (2012-04-25)
We investigated the association between polymorphisms in the p53 tumor suppressor gene and breast cancer risk in women especially in the Southern part of India. Genotyping was performed for 50 breast cancer women and 50 controls to determine the status
S Weidinger et al.
Journal of medical genetics, 41(9), 658-663 (2004-09-03)
Several studies have shown linkage of chromosome 12q 13-24 with atopy related phenotypes. Among candidate genes in this region is STAT6 (signal transducer and activator of transcription), which is essential for Th2 cell differentiation, recruitment, and effector function. We evaluated
Ian Ashmole et al.
The Journal of allergy and clinical immunology, 129(6), 1628-1635 (2012-03-14)
Influx of extracellular Ca(2+) into human lung mast cells (HLMCs) is essential for the FcεRI-dependent release of preformed granule-derived mediators and newly synthesized autacoids and cytokines. However, the identity of the ion channels underlying this Ca(2+) influx is unknown. The
Juan Peris-Vicente et al.
Journal of chromatographic science, 52(9), 1121-1126 (2013-11-14)
A capillary electrophoresis method was developed to quantify caffeine and theophylline, xanthine derivatives with bronchodilator activity. Buffer concentration, pH and applied voltage were optimized using a central composite design-face centred. Separation conditions were: silica capillary tube, 75 μm (i.d.) and
Lalji K Gediya et al.
Journal of medicinal chemistry, 51(13), 3895-3904 (2008-06-12)
Novel mutual prodrugs (MPs) of ATRA (all- trans-retinoic acid) and HDIs (histone deacetylase inhibitors) ( 10, 13, 17- 19) connected via glycine acyloxyalkyl carbamate linker (AC linker) or through a benzyl ester linker (1,6-elimination linker) were rationally designed and synthesized.
Anna Maria Ierardi et al.
La Radiologia medica, 122(1), 69-76 (2016-09-08)
To evaluate the technical and clinical success, primary patency (PP) and complications of angioplasty performed with paclitaxel-coated balloon (PCBs) associated with cutting balloon and for the treatment of the outflow stenoses of failing hemodialysis arteriovenous shunt. From September 2014 to
C L Gerez et al.
Journal of food science, 75(6), M354-M359 (2010-08-21)
The effect of lactic acid bacteria (LAB) on pathogenic fungi was evaluated and the metabolites involved in the antifungal effect were characterized. Penicillium digitatum (INTA 1 to INTA 7) and Geotrichum citri-aurantii (INTA 8) isolated from decayed lemon from commercial
Gisele C Vaz et al.
Journal of neuroscience methods, 273, 55-63 (2016-10-25)
Liposomes are concentric lipid vesicles that allow a sustained release of entrapped substances. GABA (γ-aminobutyric acid) is the most prevalent inhibitory neurotransmitter in the central nervous system. Using GABA-containing liposomes (GL) prepared by the freeze-thawing method, we determined the effect
Dominik Domanski et al.
Journal of proteomics, 75(12), 3514-3528 (2011-12-08)
In this study we demonstrate the use of a multiplexed MRM-based assay to distinguish among normal (NL) and iron-metabolism disorder mouse models, particularly, iron-deficiency anemia (IDA), inflammation (INFL), and inflammation and anemia (INFL+IDA). Our initial panel of potential biomarkers was
B Bereznai et al.
Neuromuscular disorders : NMD, 7(2), 113-116 (1997-03-01)
We report on an Austrian pedigree with autosomal dominant amyotrophic lateral sclerosis (ALS), diagnosed in six patients from two generations. The only surviving clinically affected family member was examined in our ALS clinic. Historical information on other affected individuals was
Amna Salah et al.
Journal of critical care, 24(3), e11-e14 (2009-08-12)
Lipoprotein lipase (LPL) is a rate-limiting enzyme responsible for the hydrolysis of triacylglycerol-rich lipoproteins releasing monoglycerides and free fatty acids, which are taken up by skeletal muscles and adipose tissue. S447X polymorphism in exon 9 of LPL gene on chromosome
Bai-Qi Liu et al.
Insect science, 25(5), 739-750 (2017-05-26)
Thirteen cuticular protein (CP) families have been recognized in arthropods. In this study, 250 Anopheles sinensis CP genes were identified and named based on genome and transcriptome sequences. They were classified into 10 families based on motifs and phylogenetic analyses.
Gulfer Okumus et al.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 13(1), 101-103 (2006-12-14)
Two silent polymorphisms (807C/T and 873G/A) within glycoprotein Ia (GPIa) gene have been implicated in increased risk of developing thrombosis and myocardial infarction in affected individuals. The aim of this study was to investigate the GPIa gene polymorphism in patients
T Nakayama et al.
Analytical biochemistry, 138(2), 421-424 (1984-05-01)
A rapid procedure for the purification of L-methionine gamma-lyase from Pseudomonas putida ICR 3460 by DEAE- TOYOPEARL 650M and DEAE-Sephadex A-50 column chromatography is presented. The enzyme was purified with an average yield of 75% and showed about 10-fold higher
R Ryan et al.
Irish medical journal, 105(10), 335-338 (2013-03-19)
The provision of specialist palliative care to Irish patients suffering from motor neurone disease has not been described in the literature. The purpose of this study was to characterize the care provided at a Dublin hospice. Consecutive referrals between 1st
Vinciane Rebours et al.
The American journal of gastroenterology, 104(9), 2312-2317 (2009-06-25)
Patients with hereditary pancreatitis (HP) bear a high risk of pancreatic adenocarcinoma, but their life expectancy remains unknown. The objective of the study was to assess whether the high risk of cancer decreases survival. Inclusion criteria were the presence of
M Yiallourides et al.
Reproduction (Cambridge, England), 138(3), 601-608 (2009-06-16)
Nutrient restriction (NR) during critical windows of pregnancy has differential effects on placento-fetal growth and development. Our study, therefore, investigated developmental and metabolic adaptations within the ovine placenta following NR at different critical windows during the first 110 days of
Edmondo Falleti et al.
Human immunology, 71(10), 999-1004 (2010-07-27)
Genetic polymorphisms of interleukin-6 (IL-6) (-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C) may affect the outcomes of several diseases. This study was aimed to verify the role of these polymorphisms on the disease progression of patients with hepatitis C virus (HCV) infection
A J Jonas et al.
The Journal of clinical investigation, 84(1), 200-204 (1989-07-01)
Tryptophan ethyl ester, a lipid-soluble tryptophan derivative, was used to bypass defective gastrointestinal neutral amino acid transport in a child with Hartnup disease. The child's baseline tryptophan concentrations in serum (20 +/- 6 microM) and cerebrospinal fluid (1.0 +/- 0.2
Isabelle Plante et al.
Pflugers Archiv : European journal of physiology, 452(3), 316-323 (2006-01-18)
Non-synonymous single nucleotide polymorphisms (SNPs) in the KCNA5/hKv1.5 gene, which encodes for a voltage-gated K+ channel responsible for the I (Kur) current in the human atria, have been recently reported. To gain further knowledge on potential influence of hKv1.5 SNPs
T G J Derks et al.
Journal of inherited metabolic disease, 31(1), 88-96 (2008-01-12)
The outcome was determined of population-wide neonatal screening for medium-chain acyl-CoA dehydrogenase (MCAD) deficiency using tandem mass spectrometry (MS/MS) in The Netherlands, between October 2003 and September 2005. Prospective population-wide neonatal screening for MCAD deficiency was performed in the northern
Rafal Pawliczak et al.
Physiological genomics, 23(1), 28-45 (2005-06-30)
Interferon gamma (IFN-gamma) plays a role in a variety of lung inflammatory responses, and corticosteroids are frequently employed as a treatment in these conditions. Therefore, the effect of IFN-gamma, of the corticosteroid dexamethasone (Dex), or of both on gene expression
Prithviraj Karaka et al.
Biological & pharmaceutical bulletin, 27(12), 2010-2013 (2004-12-04)
Dicyclomine hydrochloride is an antispasmodic agent. The MIC of dicyclomine against standard strains of Gram positive and Gram negative bacteria were performed by NCCLS broth dilution technique. These drugs showed a rapid killing action on Gram positive bacteria, Staphylococcus aureus
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