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Djouher Ait-Idir et al.
Rheumatology (Oxford, England), 50(12), 2306-2310 (2011-10-25)
FMF is characterized by recurrent self-limiting episodes of fever and painful polyserositis. We aimed to study the spectrum and distribution of MEFV mutations in an Algerian patient cohort using a comprehensive mutation detection method. Using the same methodology, we also
X B Han et al.
Marine pollution bulletin, 63(5-12), 160-165 (2011-05-10)
Polybrominated diphenyl ethers (PBDEs) are now found ubiquitously in the aquatic environment and biota, and there is a growing concern that PBDEs may disrupt endocrine systems, leading to reproductive impairments of aquatic animals. In our study, zebrafish (Danio rerio) were
M Kovacs et al.
Endocrinology, 138(11), 4536-4542 (1997-11-05)
Transgenic mice overexpressing the human GH-releasing hormone (hGHRH) gene, an animal model of acromegaly, were used to investigate the effects of potent GHRH antagonists MZ-4-71 and MZ-5-156 on the excessive GH and insulin-like growth factor I (IGF-I) secretion caused by
Diego Sánchez-Muñoz et al.
European journal of gastroenterology & hepatology, 16(8), 761-765 (2004-07-17)
To determine whether the different tumour necrosis factor alpha (TNF-alpha) promoter gene polymorphisms are involved in the development of steatosis in chronic hepatitis C. One hundred and thirty patients (89 men and 41 women; mean age 42.5 +/- 12.3 years)
Deborah J L Wong et al.
Molecular cancer, 13, 194-194 (2014-08-22)
In melanoma, dysregulation of the MAPK pathway, usually via BRAF(V600) or NRAS(Q61) somatic mutations, leads to constitutive ERK signaling. While BRAF inhibitors are initially effective for BRAF-mutant melanoma, no FDA-approved targeted therapies exist for BRAF-inhibitor-resistant BRAF(V600), NRAS mutant, or wild-type
Kenji Sasaki et al.
Bioorganic & medicinal chemistry, 12(6), 1367-1375 (2004-03-17)
Biological activity of N-acetyl-6-sulfo-beta-d-glucosaminides (6-sulfo-GlcNAc 1) having a structural homology to N-acetylneuraminic acid (Neu5Ac 2) and 2-deoxy-2,3-dehydro-N-acetylneuraminic acid (Neu5Ac2en 3) was examined in terms of inhibitory activity against influenza virus sialidase (influenza, A/Memphis/1/71 H3N2). pNP 6-Sulfo-GlcNAc 1a was proved to
Maria Luisa Testa et al.
Materials (Basel, Switzerland), 13(5) (2020-03-12)
Different solid sulfonic titania-based catalysts were investigated for the hydrothermal dehydration of fructose to 5-hydroxymethylfurfural (5-HMF). The catalytic behavior of the materials was evaluated in terms of fructose conversion and selectivity to 5-HMF. The surface and structural properties of the
J V Cohen et al.
Familial cancer, 11(1), 69-75 (2011-09-08)
Risk-reducing salpingo-oophorectomy (RRSO) significantly reduces the risk of ovarian cancer and breast cancer in pre-menopausal women with BRCA1 and BRCA2 (B1/2) mutations. Despite its clear benefits, little is known about non-cancer endpoints in this population. Medical records were examined in
P Rheault et al.
Biochimica et biophysica acta, 1447(1), 17-24 (1999-09-29)
17beta-Hydroxysteroid dehydrogenases (17beta-HSDs) play a crucial role in the control of active sex steroid intracellular levels. Seven types of 17beta-HSD have been described. In this study, we report the cloning and characterization of the mouse type 5 17beta-HSD belonging to
Radoslav Halko et al.
Journal of AOAC International, 89(5), 1403-1409 (2006-10-18)
A simple and fast analytical method was developed for the determination of benzimidazole fungicides (benomyl, carbendazim, thiabendazole, and fuberidazole) in soil samples. The analytes were extracted from the soil samples by means of conventional microwave-assisted extraction, using the non-ionic surfactants
Roger Reidelberger et al.
American journal of physiology. Endocrinology and metabolism, 307(8), E619-E629 (2014-08-15)
Cholecystokinin (CCK)-induced suppression of feeding is mediated by vagal sensory neurons that are destroyed by the neurotoxin capsaicin (CAP). Here we determined whether CAP-sensitive neurons mediate anorexic responses to intravenous infusions of gut hormones peptide YY-(3-36) [PYY-(3-36)] and glucagon-like peptide-1
Eugenia Vispo et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 56(8), 1117-1122 (2013-01-15)
Noncirrhotic portal hypertension (NCPH) is a rare but potentially life-threatening complication in patients with human immunodeficiency virus (HIV). Cases of NCPH have been reported in HIV-negative individuals as result of treatment with thiopurines for leukemia or inflammatory bowel disease. Exposure
Smaranda Leu-Semenescu et al.
Neurology, 85(19), 1655-1662 (2015-10-11)
To compare the benefits and risks of lithium therapy vs abstention/other treatments in Kleine-Levin syndrome (KLS). In a KLS cohort followed in a single center, 130 patients regularly took lithium carbonate (median dose 1,000 mg/day; n = 71; 40 children)
Cheng-Lin Deng et al.
Journal of virology, 88(20), 11915-11923 (2014-08-08)
Enterovirus 71 (EV71) is a major viral pathogen in China and Southeast Asia. There is no clinically approved vaccine or antiviral therapy for EV71 infection. NITD008, an adenosine analog, is an inhibitor of flavivirus that blocks viral RNA synthesis. Here
Ingu Do et al.
Pathology, research and practice, 203(3), 127-134 (2007-02-15)
Ewing sarcoma is a highly malignant tumor of bone preferentially arising in children and young adults. Its 5-year survival rate is only 50% despite the use of multimodal therapeutic approaches, requiring a search for new therapeutic targets and the development
P Virkkunen et al.
Biochemical and biophysical research communications, 202(1), 49-57 (1994-07-15)
Structural comparison of human and rat prostate-specific acid phosphatase (hPAP and rPAP) genes indicate that the exon number is different between these species. The hPAP gene contains 10 exons, whereas the rPAP gene was 11 exons. However, exons 2-9 of
G L Kennedy
Journal of applied toxicology : JAT, 11(5), 367-371 (1991-10-11)
1,4-Bis(aminocyclohexyl)methane (PACM; CAS No. 1761-71-3) is a white solid considered for use in polymeric systems. PACM is moderately toxic systemically, with the acute oral lethal dose in rats between 670 and 1000 mg kg-1. PACM is a weak dermal sensitizer
J J Ramos et al.
Journal of chromatography. A, 1216(43), 7307-7313 (2009-06-03)
The feasibility of a miniaturised generic sample preparation method based on matrix solid-phase dispersion for the determination of three relevant classes of pesticides (organophosphorus pesticides, triazines and pyrethroids) in selected fruits, i.e. orange, apple, pear and grape, have been demonstrated.
Sara Ekeblad et al.
World journal of surgery, 36(6), 1411-1418 (2011-11-18)
Better prognostic markers are needed for pancreatic endocrine tumors. Survivin is an apoptosis inhibitor that is suggested to have a negative prognostic impact in several tumor types. Contradictory data exist, especially regarding the significance of a nuclear versus cytoplasmic location
R L J van Wanrooij et al.
Journal of clinical immunology, 34(7), 828-835 (2014-07-27)
Different strategies have been developed to identify those refractory celiac disease (RCD) patients who are at risk to develop an enteropathy associated T-cell lymphoma (EATL). Flow cytometric analysis of intra-epithelial lymphocytes (IEL) with an aberrant phenotype is considered the golden
Asal Fallah-Tafti et al.
European journal of medicinal chemistry, 46(10), 4853-4858 (2011-08-20)
KX2-391 (KX-01/Kinex Pharmaceuticals), N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide, is a highly selective Src substrate binding site inhibitor. To understand better the role of pyridine ring and N-benzylsubstitution in KX2-391 and establish the structure-activity relationship, a number of N-benzyl substituted (((2-morpholinoethoxy)phenyl)thiazol-4-yl)acetamide derivatives containing thiazole instead
Shashank Jain et al.
Pharmaceutical development and technology, 20(4), 473-489 (2014-02-05)
The objective of this study was to fabricate and understand ethosomal formulations of diclofenac (DF) for enhanced anti-inflammatory activity using quality by design approach. DF-loaded ethosomal formulations were prepared using 4 × 5 full-factorial design with phosphatidylcholine:cholesterol (PC:CH) ratios ranging
Mingquan Chen et al.
Anesthesia and analgesia, 118(4), 863-868 (2014-03-22)
In this study, we sought to determine the median effective dose (ED50) for motor block of intrathecally administered plain bupivacaine in adults (20-80 years) and to assess the effect of age on ED50 required for motor block. This study was
Glutamate uptake shapes low-[Mg2+] induced epileptiform activity in juvenile rat hippocampal slices.
Gabriella Nyitrai et al.
Brain research, 1309, 172-178 (2009-11-17)
A wide range of data support a role for ambient glutamate (Glu) in epilepsy, although temporal patterns associated with the cellular uptake of Glu have not been addressed in detail. We report on the effects of Glu uptake inhibitors on
Ruiqing Ma et al.
BMC cancer, 20(1), 280-280 (2020-04-08)
To investigate the clinical and pathological characteristics of appendiceal mucinous adenocarcinoma with peritoneal metastasis and analyze the prognostic factors. A retrospective analyses of clinicopathological features of 50 patients with appendiceal mucinous adenocarcinoma with peritoneal metastasis from January, 2013 to December
Vinata B Lokeshwar et al.
The Journal of biological chemistry, 283(43), 29215-29227 (2008-08-23)
HYAL-1 (hyaluronoglucosaminidase-1) belongs to the hyaluronidase family of enzymes that degrade hyaluronic acid. HYAL-1 is a marker for cancer diagnosis and a molecular determinant of tumor growth, invasion, and angiogenesis. The regulation of HYAL-1 expression is unknown. Real time reverse
Zisis Vryzas et al.
Journal of separation science, 30(15), 2529-2538 (2007-09-01)
A well-validated analytical method based on microwave-assisted extraction (MAE) and SPE is presented for the combined analysis of alachlor, alachlor-oxanilic acid (OXA), alachlor-ethanesulfonic acid (ESA), metolachlor, metolachlor-OXA, metolachlor-ESA residues in soils. Extraction of solutes by soil sample was carried out
Carola Buccellati et al.
The Journal of pharmacology and experimental therapeutics, 317(2), 830-837 (2006-01-10)
Thromboxane (TX) A(2), prostacyclin (PGI(2)), and nitric oxide (NO) regulate platelet function and interaction with the vessel wall. Inhibition of TXA(2), implemented synthesis of PGI(2), and supply of exogenous NO may afford therapeutic benefit. 2NTX-99 [4-methoxy-N(1)-(4-trans-nitrooxycyclohexyl)-N(3)-(3-pyridinylmethyl)-1,3-benzenedicarboxamide], a new chemical entity
Kyoichi Kaira et al.
Annals of surgical oncology, 16(12), 3473-3481 (2009-09-25)
The purpose of this study was to evaluate the prognostic value of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in resectable non-small-cell lung cancer (NSCLC) patients with N1 and N2 nodal involvement. A total of
Konstantinos Grintzalis et al.
Free radical research, 43(9), 803-808 (2009-06-24)
The time-related alterations of superoxide radical measured in vivo by employing an ultrasensitive fluorescent assay in the liver, intestine, kidney and brain of rats with experimentally induced obstructive jaundice was investigated. Eighteen rats were randomly divided into Group A, rats
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