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Gui-Xin He et al.
Journal of medical microbiology, 63(Pt 5), 735-741 (2014-03-04)
We isolated a total of 653 strains from 64 community environmental samples in Massachusetts, USA. Among these isolates, 9.65 % (63 strains) were benzalkonium chloride (BC)-resistant staphylococci. All BC-resistant strains were collected from surfaces upon which antibacterial wipes or antibacterial sprays
David S Wishart et al.
Nucleic acids research, 37(Database issue), D603-D610 (2008-10-28)
The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community. Since its first release in 2007, the
Fengzhen Wang et al.
Journal of liposome research, 24(3), 171-181 (2014-03-13)
The purpose of the present study was to optimize methazolamide (MTZ)-loaded solid lipid nanoparticles (SLNs) which were used as topical eye drops by evaluating the relationship between design factors and experimental data. A three factor, three-level Box-Behnken design (BBD) was
Ting He et al.
Molecular and cellular endocrinology, 402, 13-20 (2014-12-30)
Resveratrol (RSV) is reported to have renoprotective activity against diabetic nephropathy, while the mechanisms underlying its function have not been fully elucidated. In this study, we investigate the effect and related mechanism of RSV against high glucose-induced epithelial to mesenchymal
Charudharshini Srinivasan et al.
International journal of pharmaceutics, 481(1-2), 104-113 (2015-02-01)
Drug shortages and recalls are often caused due to particulate growth in parenteral products and can have serious clinical implications. Root cause analysis of such recalls and shortages may arise due to insufficient understanding of process, formulations issues and environmental
Yasuo Uchida et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1719-1726 (2014-07-26)
The purpose of this study was to demonstrate experimentally that alterations of in vivo transporter function at the blood-brain barrier (BBB) in disease and during pharmacotherapy can be reconstructed from in vitro data based on our established pharmacoproteomic concept of
B Berchtold et al.
Journal of dairy science, 97(8), 4886-4896 (2014-06-03)
Bovine mastitis is a frequent problem in Swiss dairy herds. One of the main pathogens causing significant economic loss is Staphylococcus aureus. Various Staph. aureus genotypes with different biological properties have been described. Genotype B (GTB) of Staph. aureus was
M M Santana et al.
Mikrobiologiia, 81(6), 720-725 (2013-04-25)
Desulfovibrio vulgaris Hildenborough genome presents a phosphotransferase system putatively involved in the transport of carbohydrates. However, utilization of sugars by this sulfate-reducing bacterium has never been reported. Herein, we have observed proliferation of D. vulgaris Hildenborough with some carbohydrates, in
Georg Bauer et al.
Carcinogenesis, 35(7), 1582-1591 (2014-03-26)
Malignant transformation of gastric epithelial cells by chronic Helicobacter pylori infection is caused by several mechanisms including attraction of reactive oxygen species (ROS)-producing neutrophils and cytotoxin-associated antigen A-mediated dysplastic alterations. Here we show that H.pylori protects transformed cells from ROS-mediated
Emma C Hansson et al.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 46(4), 699-705 (2014-02-01)
Ticagrelor reduces thrombotic events compared with clopidogrel in patients with acute coronary syndrome, but may also increase bleeding complications. Coronary artery bypass grafting (CABG)-related bleeding complications have not previously been compared in clopidogrel and ticagrelor-treated patients outside the controlled environment
K H Polderman et al.
Critical care medicine, 31(2), 584-590 (2003-02-11)
Mannitol is widely used in hospitals worldwide to treat patients with high intracranial pressure and/or cerebral edema. One of the mechanisms by which mannitol is thought to affect intracranial pressure is by increasing the patient's serum osmolarity, but not the
M A Raskind et al.
Biological psychiatry, 46(6), 756-765 (1999-09-24)
High cerebrospinal fluid (CSF) norepinephrine (NE) concentrations in aging and Alzheimer's disease (AD) could reflect decreased NE clearance from central nervous system (CNS) extracellular fluid or increased release of NE into CNS extracellular fluid. Measuring CSF concentrations of the intraneuronal
M O Kristensen et al.
Acta neurologica Scandinavica, 87(6), 475-481 (1993-06-01)
The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20). Supplementing serum cobalamin we measured methylmalonic acid (MMA), a metabolite
Abel Wakai et al.
The Cochrane database of systematic reviews, 8(8), CD001049-CD001049 (2013-08-07)
Mannitol is sometimes effective in reversing acute brain swelling, but its effectiveness in the ongoing management of severe head injury remains unclear. There is evidence that, in prolonged dosage, mannitol may pass from the blood into the brain, where it
Eman F Ahmed et al.
Surgical infections, 15(4), 404-411 (2014-05-13)
Staphylococcus aureus (S. aureus) is isolated frequently from surgical site infections and other soft tissue infections. There are limited data examining the prevalence of methicillin resistant S. aureus (MRSA) among Egyptian patients after surgery. The current study determined the prevalence
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bet 1. Rhabdomyolysis and the use of sodium bicarbonate and/or mannitol.
Rachel Thomas
Emergency medicine journal : EMJ, 27(4), 305-308 (2010-04-14)
Christopher J Burns et al.
Bioorganic & medicinal chemistry letters, 19(20), 5887-5892 (2009-09-19)
A series of phenylaminopyrimidines has been identified as inhibitors of Janus kinases (JAKs). Development of this initial series led to the potent JAK2/JAK1 inhibitor CYT387 (N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzamide). Details of synthesis and SAR studies of these compounds are reported.
Vesicant extravasation.
Vincent M Vacca
Nursing, 43(9), 21-22 (2013-08-22)
Young-Hee Cho et al.
PLoS genetics, 7(1), e1001263-e1001263 (2011-01-22)
Sugars are evolutionarily conserved signaling molecules that regulate the growth and development of both unicellular and multicellular organisms. As sugar-producing photosynthetic organisms, plants utilize glucose as one of their major signaling molecules. However, the details of other sugar signaling molecules
Yub Raj Neupane et al.
International journal of pharmaceutics, 477(1-2), 601-612 (2014-12-03)
The aim of this study was to design and fabricate nanostructured lipid carrier (NLC) for the potential oral delivery of decitabine (DCB). NLC was prepared by cold homogenization technique and optimized by the Box-Behnken experimental design. It was further characterized
Mathilde Severac et al.
The American journal of emergency medicine, 32(7), 813-813 (2014-01-28)
A 42-year-old woman presented to our emergency department with headache, nausea, and confusion after completing an Ironman triathlon. She performed the race at a slow pace, in hot and dry weather. The first medical examination reported confusion with a Glasgow
Anas Al-Hussein et al.
Pharmaceutical development and technology, 20(1), 50-59 (2013-11-30)
The objective of this study was to investigate both the cryoprotective and lyoprotective effects of the polymer hydroxyethyl cellulose (HEC) on the model protein lactate dehydrogenase (LDH) during freeze thawing and freeze drying cycles. The effect of annealing on both
Oluwatoyin A Igbeneghu et al.
Journal of health, population, and nutrition, 32(2), 176-182 (2014-08-01)
Fluted pumpkin (Telfairia occidentalis) is a minimally-processed green leafy vegetable traditionally used for its antianaemic properties in the form of leaf juice without a heating or inactivation step before consumption. The aim of the study was to assess the presence
Tao Chen et al.
Asian Pacific journal of allergy and immunology, 32(4), 345-353 (2014-12-30)
The intestinal tract plays an important role in food allergy and the intestinal mucosa barrier is critical for maintenance of its function. The underlying mechanisms of how food allergens modulate the intestinal permeability in inducing intestinal food allergy remain elusive.
Kerin L Tyrrell et al.
Journal of clinical microbiology, 51(9), 3094-3096 (2013-06-28)
Cycloserine-cefoxitin fructose agar (CCFA), CCFA with horse blood and taurocholate (CCFA-HT), and cycloserine-cefoxitin mannitol broth with taurocholate and lysozyme (CCMB-TAL) were compared for recovery of Clostridium difficile from 120 stool specimens. Compared to CCFA, CCFA-HT enhanced C. difficile growth and
Alan Talevi et al.
European journal of medicinal chemistry, 46(1), 218-228 (2010-11-30)
In order to minimize the high attrition rate that usually characterizes drug research and development projects, current medicinal chemists aim to characterize both pharmacological and ADME profiles at the beginning of drug R&D initiatives. Thus, the development of ADME High-Throughput
Susanne T Wessling et al.
Bioorganic & medicinal chemistry, 15(14), 4946-4950 (2007-05-15)
Caco-2 cell permeability and stability assays were used as an in vitro model to study the intestinal epithelial transport and stability of two analogues of thyrotropin-releasing hormone (TRH; Pyr-His-Pro-NH2). Peptide 1 (Pyr-His-Pro-D-glucopyranuronamide) was more permeable across the Caco-2 cell monolayer
Siti Nur Fadzilah Muhsain et al.
Toxicology and applied pharmacology, 282(1), 77-89 (2014-12-06)
The intracellular level of bilirubin (BR), an endogenous antioxidant that is cytotoxic at high concentrations, is tightly controlled within the optimal therapeutic range. We have recently described a concerted intracellular BR regulation by two microsomal enzymes: heme oxygenase 1 (HMOX1)
Badal C Saha et al.
Applied microbiology and biotechnology, 89(4), 879-891 (2010-11-11)
Mannitol, a naturally occurring polyol (sugar alcohol), is widely used in the food, pharmaceutical, medical, and chemical industries. The production of mannitol by fermentation has become attractive because of the problems associated with its production chemically. A number of homo-
Jennifer L Infanti
The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 40(6), 362-368 (2009-01-28)
Mannitol has long been the "gold standard" for treatment of cerebral edema and refractory intracranial hypertension in traumatic brain injury, subarachnoid hemorrhage, and stroke. Studies performed in animals have shown that hypertonic saline (HS), in doses ranging from 3% to
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