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Sourav Majumdar et al.
International journal of biological macromolecules, 79, 477-489 (2015-05-13)
Fibrin(ogen)olytic enzymes offer great promise for the treatment of thrombosis associated disorders. The present study describes the characterization of an extracellular fibrin(ogen)olytic serine protease (named Bacethrombase) purified from the Bacillus cereus strain FF01. The molecular mass of the Bacethrombase was
T. Bartok et al.
Journal of Liquid Chromatography, 17, 4391-4391 (1994)
Wei Wang et al.
Journal of neuroscience research, 90(6), 1218-1229 (2012-02-23)
Serine racemase (SR) is the only identified enzyme in mammals responsible for isomerization of L-serine to D-serine, a coagonist at N-methyl-D-aspartate (NMDA) receptors in the forebrain. Our previous data showed that an apparent SR dimer resistant to sodium dodecyl sulfate
Zuzana Bubelová et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 50(11), 797-808 (2015-09-12)
The aim of this study was to evaluate the combined effect of temperature (10, 20 and 37°C), pH (4, 5, 6, 7 and 8), and NaCl content (0, 1, 3, 4, 5 and 6% w/v) on the growth and putrescine
Jing Wang et al.
Talanta, 89, 422-426 (2012-01-31)
Aiming to find an alternative electrochemiluminescence (ECL) quenching route of high efficiency, biocatalytic precipitation (BCP) was firstly coupled with ECL for investigating its insulating effect on ECL. Experimental data revealed that an insulating layer could be formed via BCP onto
Celeste R Brennecka et al.
Journal of neurosurgery, 119(1), 228-238 (2013-04-09)
Over the past 20 years, endovascular embolization has become the preferred method of treating cerebral aneurysms. While there are many embolic devices on the market, none is ideal. In this study the authors investigated the use of a liquid-to-solid gelling
Yoshikazu Ishii et al.
Antimicrobial agents and chemotherapy, 54(9), 3625-3629 (2010-07-08)
ME1071, a maleic acid derivative, is a novel specific inhibitor for metallo-beta-lactamases (MBL). In this study, the potentiation of ME1071 in combination with several beta-lactams was evaluated using MBL-producing Pseudomonas aeruginosa isolates. The rates of susceptibility of MBL producers to
Yakup Aykut et al.
ACS applied materials & interfaces, 4(8), 3837-3845 (2012-07-18)
We report on the microstructural crystal phase transformation of electrospun TiO(2) nanofibers generated via sol-gel electrospinning technique, and the incorporation of as-synthesized CdSe quantum dots (QDs) to different phases of TiO(2) nanofibers (NFs) via bifunctional surface modification. The effect of
Uma M Bhalerao et al.
Colloids and surfaces. B, Biointerfaces, 125, 151-159 (2014-12-09)
Herein we report the in-vitro controlled release properties of 1, 3, 5-trisubstituted-2-pyrazolines through Layer-by-Layer (LbL) self assembled thin films fabricated from chitosan and heparin sodium salt as biocompatible polyelectrolytes. This study was carried out as a preliminary step towards the
Qijin Wan et al.
Colloids and surfaces. B, Biointerfaces, 104, 181-185 (2013-01-15)
In order to construct a three-dimensional electrode, in situ electrochemical deposition of gold nanoparticles onto a gold electrode coated with a self-assembled monolayer of 3-mercaptopropionic acid (Au NP/MPA/Au) was conducted. Horseradish peroxidase (HRP) was then immobilized into this three-dimensional electrode
D Kutlán et al.
Journal of chromatography. A, 949(1-2), 235-248 (2002-05-10)
A comprehensive evaluation of papers dealing with the HPLC quantitation of amines as o-phthaldialdehyde (OPA) derivatives has been given and discussed in details. The stability and characteristics of selected representatives of mono [methyl-, ethyl-, n-/isopropyl, n-/isobutyl-, tert.-butyl-, sec.-butyl-, isoamyl amines
Patrick R Brown et al.
ACS nano, 8(6), 5863-5872 (2014-05-16)
The electronic properties of colloidal quantum dots (QDs) are critically dependent on both QD size and surface chemistry. Modification of quantum confinement provides control of the QD bandgap, while ligand-induced surface dipoles present a hitherto underutilized means of control over
Oliva M Primera-Pedrozo et al.
Nanoscale, 4(4), 1312-1320 (2012-01-26)
An aqueous route of synthesis is described for rapid synthesis of lead selenide quantum dots (PbSe QDs) at room temperature in an attempt to produce water-soluble and stable nanocrystals. Several thiol-ligands, including thioglycolic acid (TGA), thioglycerol (TGC), 3-mercaptopropionic acid (MPA)
Mao Shen et al.
Nanoscale research letters, 9(1), 558-558 (2014-10-21)
In this paper, we investigated the functional imaging properties of magnetic microspheres composed of magnetic core and CdTe quantum dots in the silica shell functionalized with folic acid (FA). The preparation procedure included the preparation of chitosan-coated Fe3O4 nanoparticles (CS-coated
Justin D Besant et al.
Nature communications, 6, 6978-6978 (2015-04-23)
Diagnosis of disease outside of sophisticated laboratories urgently requires low-cost, user-friendly devices. Disposable, instrument-free testing devices are used for home and physician office testing, but are limited in applicability to a small class of highly abundant analytes. Direct, unambiguous visual
Zhanxi Fan et al.
Nature communications, 6, 6571-6571 (2015-03-15)
Conventionally, the phase transformation of inorganic nanocrystals is realized under extreme conditions (for example, high temperature or high pressure). Here we report the complete phase transformation of Au square sheets (AuSSs) from hexagonal close-packed (hcp) to face-centered cubic (fcc) structures
Jaco Franken et al.
Applied microbiology and biotechnology, 99(15), 6377-6389 (2015-04-09)
Industrial synthesis of L-carnitine is currently performed by whole-cell biotransformation of industrial waste products, mostly D-carnitine and cronobetaine, through specific bacterial species. No comparable system has been established using eukaryotic microorganisms, even though there is a significant and growing international
Meng-Nan Ma et al.
Analytical chemistry, 87(22), 11389-11397 (2015-10-13)
A highly sensitive electrochemiluminescent (ECL) aptasensor was constructed using semicarbazide (Sem) as co-reaction accelerator to promote the ECL reaction rate of CdTe quantum dots (CdTe QDs) and the co-reactant of peroxydisulfate (S2O8(2-)) for boosting signal amplification. The co-reaction accelerator is
Wafa M Elbjeirami
Kidney international, 80(11), 1115-1117 (2011-11-16)
Interstitial fibrosis plays a major role in the progression of renal diseases. Peroxisome proliferator-activated receptor-α (PPAR-α) ligands are increasingly explored for their potential to reverse or halt tubulointerstitial fibrosis. This Commentary discusses new findings by Boor et al., who show
István Hornyák et al.
Free radical research, 46(2), 214-225 (2011-12-14)
S-nitrosothiol (RSNO) solutions represent a valuable source of nitric oxide and could be used as topical vasodilators, but their fast decomposition rate poses a serious obstacle to their potentially widespread therapeutic use. Our aim was to characterize and quantify the
Feng Jiang et al.
Langmuir : the ACS journal of surfaces and colloids, 28(36), 12931-12940 (2012-08-14)
A strong ligand effect was observed for the aqueous-phase growth of ZnSe quantum dots (QDs) in the Ostwald ripening (OR) stage. The QDs were made by injecting Se monomer at room temperature followed by a ramp to 100 °C. The
Ramesh Chennupati et al.
PloS one, 9(7), e102264-e102264 (2014-07-18)
Argininosuccinate synthetase (ASS) is essential for recycling L-citrulline, the by-product of NO synthase (NOS), to the NOS substrate L-arginine. Here, we assessed whether disturbed arginine resynthesis modulates endothelium-dependent vasodilatation in normal and diabetic male mice. Endothelium-selective Ass-deficient mice (Assfl/fl/Tie2Cretg/- = Ass-KOTie2) were
Siyi Hu et al.
The Analyst, 139(18), 4681-4690 (2014-07-24)
Biofunctionalized quantum dots (QDs), especially protein-coated QDs, are known to be useful targeted fluorescent labels for cellular and deep-tissue imaging. These nanoparticles can also serve as efficient energy donors in fluorescence resonance energy transfer (FRET) binding assays for the multiplexed
Estefanía de Munck et al.
Environmental toxicology and pharmacology, 39(3), 1232-1245 (2015-05-24)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscle paralysis that reflects the motoneurons' degeneration. Several studies support the relationship between β-N-methylamino-l-alanine (l-BMAA), a neurotoxic amino acid produced by cyanobacteria and diatoms, and the sporadic occurrence of
Sabyasachi Bagchi et al.
The journal of physical chemistry. A, 117(7), 1601-1613 (2013-01-22)
Density functional theory was applied to study the interaction of group IIb transition-metal cations (Zn(2+), Cd(2+), and Hg(2+)) with one and two fully or partially deprotonated 3-mercaptopropionic acid ligands. In this investigation, we determined the geometries of all possible complexes
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside.
Henri Mattes et al.
Journal of medicinal chemistry, 53(15), 5367-5382 (2010-04-02)
Ramprasad Kandavar et al.
Journal of clinical hypertension (Greenwich, Conn.), 17(1), 14-19 (2014-12-17)
Prehypertension is an important phenotype for cardiovascular risk and development of established hypertension. To better understand the early circulatory changes in this group, the authors studied 34 patients with prehypertension (blood pressure 120-139/80-89 mm Hg) using digital plethysmography for measurement
Richard J Souness et al.
Biochemistry, 52(43), 7606-7617 (2013-10-03)
Describing the organization of substrates and substrate analogues in the active site of cysteine dioxygenase identifies potential intermediates in this critical yet poorly understood reaction, the oxidation of cysteine to cysteine sulfinic acid. The fortuitous formation of persulfides under crystallization
Benoît M R Liénard et al.
Journal of medicinal chemistry, 51(3), 684-688 (2008-01-22)
The use of protein ESI mass spectrometry under non-denaturing conditions to analyze a dynamic combinatorial library of thiols/disulfides with the BcII metallo-beta-lactamase enabled the rapid identification of an inhibitor with a K(i) of < 1 microM. The study exemplifies the
Zoltan Nemeth et al.
PloS one, 10(8), e0135498-e0135498 (2015-08-28)
Pericardial fluid (PF) contains several biologically active substances, which may provide information regarding the cardiac conditions. Nitric oxide (NO) has been implicated in cardiac remodeling. We hypothesized that L-arginine (L-Arg) precursor of NO-synthase (NOS) and asymmetric dimethylarginine (ADMA), an inhibitor
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