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Gunhyuk Park et al.
Journal of medicinal food, 17(8), 862-868 (2014-06-26)
Contact dermatitis (CD) is a pattern of inflammatory responses in the skin that occurs through contact with external factors. The clinical picture is a polymorphic pattern of skin inflammation characterized by a wide range of clinical features, including itching, redness
Manouela V Valtcheva et al.
The journal of pain : official journal of the American Pain Society, 16(4), 346-356 (2015-02-03)
Chronic pruritic conditions are often associated with dry skin and loss of epidermal barrier integrity. In this study, repeated application of acetone and ether followed by water (AEW) to the cheek skin of mice produced persistent scratching behavior with no
Julia M Lewis et al.
The Journal of investigative dermatology, 135(5), 1405-1414 (2014-09-19)
Cutaneous squamous cell carcinoma (SCC) is the most prevalent invasive malignancy with metastatic potential. The epidermis is exposed to a variety of environmental DNA-damaging chemicals, principal among which are polyaromatic hydrocarbons (PAHs) ubiquitous in the environment, tobacco smoke, and broiled
Petr Tůma et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 821(1), 53-59 (2005-05-19)
Capillary electrophoretic (CE) method was developed for the determination of urinary 3-methylhistidine (3MH) and 1-methylhistidine (1MH) indicating the extent of degradation of skeletal muscle proteins and thereby the state of human health. 3MH, 1MH and histidine can be separated in
Xiaolin Li et al.
NPJ breast cancer, 7(1), 132-132 (2021-10-09)
Chemotherapy-induced ovarian dysfunction is a serious adverse effect in premenopausal patients with cancer. Gonadotrophin-releasing hormone analogs (GnRHa) protect ovarian function, but its molecular mechanisms have not yet been determined. In this study, we attempted to determine the previously unknown molecular
Jianpeng Sheng et al.
eLife, 10 (2021-03-27)
Dendritic cells residing in the skin represent a large family of antigen-presenting cells, ranging from long-lived Langerhans cells (LC) in the epidermis to various distinct classical dendritic cell subsets in the dermis. Through genetic fate mapping analysis and single-cell RNA-sequencing
M Y Khuhawar et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 873(1), 15-19 (2008-09-02)
Capillary gas chromatographic (GC) determination of methylglyoxal (MGo) was developed on the basis of precolumn derivatization with 1,2-diaminopropane (DAP) at pH 3. The elution was carried out on an HP-5 (30 m x 0.32 mm i.d.) connected with FID. The
Konrad Kleszczyński et al.
Journal of pineal research, 58(1), 117-126 (2014-11-27)
Melatonin, a lipophilic compound synthesized and released from the pineal gland, effectively acts against ultraviolet radiation (UVR), one of the main inducers of epidermal damage, skin cancer, inflammation, and DNA photo damage. One of the common known stress protein induced
Shabir Ahmad Lone et al.
BMC complementary medicine and therapies, 20(1), 131-131 (2020-05-01)
The global prevalence of fungal diseases is increasing rapidly, which affects more than a billion people every year with significant mortality rate. On the other hand, the development of new drugs to treat these fungal infections is slow, while the
Natural killer T cells are essential for the development of contact hypersensitivity in BALB/c mice.
Chihiro Shimizuhira et al.
The Journal of investigative dermatology, 134(11), 2709-2718 (2014-04-24)
Contact hypersensitivity (CHS) has been widely used to study cutaneous immune responses, as a prototype of delayed-type hypersensitivity. Although natural killer T (NKT) cells have been assumed to have an important role in CHS, their role is controversial. Here, we
Hiba Al-Hamidi et al.
Pharmaceutical development and technology, 20(1), 74-83 (2014-01-08)
The solid dispersion technique is one of the most effective methods for improving the dissolution rate of poorly water-soluble drugs; however this is reliant on a suitable carrier and solvent being selected. The work presented explores amino sugars (d-glucosamine HCl
Xiaoxia Yang et al.
Environmental science and pollution research international, 22(9), 6696-6712 (2014-11-26)
The concentrations, distribution, possible sources, and cancer risks of polycyclic aromatic hydrocarbons (PAHs) in total suspended particles (TSPs) and surface soils collected from the same sampling spots were compared in Kunming, China. The total PAH concentrations were 9.35-75.01 ng/m(3) and
Dian Zhang et al.
Nutrition and cancer, 67(1), 177-190 (2014-11-21)
Nuclear factor-kappa B (NF-κB) is an important molecule in mediating inflammatory colitis, which can lead to colorectal cancer (CRC). The aim of this study was to evaluate the chemopreventive efficacy of apple polysaccharide extract (AP) in inhibiting NF-κB-mediated inflammation pathways
Lin Sha et al.
Clinical and experimental medicine, 15(1), 55-64 (2014-08-02)
The function of the epithelial-to-mesenchymal transition (EMT) during hepatocellular carcinoma (HCC) progression is well established. However, the regulatory mechanisms modulating this phenomenon remain unclear. Homeobox B9 (HOXB9) has been proposed as an oncogene in many cancer developments, but its function
Supradip Saha et al.
Food chemistry, 177, 369-375 (2015-02-11)
Accelerated solvent extraction (ASE) is applied for the extraction of carotenoids from orange carrot and the extraction parameters were optimized. Two carotenoids, lutein and β-carotene, are selected as the validation process. Hildebrand solubility parameters and dielectric constant of solvents were
James Townsend et al.
ACS nano, 8(7), 6970-6978 (2014-06-21)
We report the fabrication of flexible chains of ferromagnetic Ni nanoparticles that possess the ability to adapt other than the typically observed rigid (nearly) straight configurations in the absence of an external magnetic field. The dynamic mobility of the ferromagnetic
Iain R White et al.
Journal of breath research, 7(1), 017112-017112 (2013-03-01)
The prospects for exploiting proton transfer reaction-time of flight-mass spectrometry (PTR-ToF-MS) in medical diagnostics are illustrated through a series of case studies. Measurements of acetone levels in the breath of 68 healthy people are presented along with a longitudinal study
Tomoya Katakai et al.
Journal of immunology (Baltimore, Md. : 1950), 193(2), 617-626 (2014-06-18)
T cells exhibit high-speed migration within the paracortical T zone of lymph nodes (LNs) as they scan cognate Ags displayed by dendritic cells in the tissue microenvironment supported by the network of stromal cells. Although intranodal T cell migration is
Milena M Madry et al.
Bioanalysis, 6(23), 3183-3196 (2014-12-23)
Toenails were assessed as an alternative matrix to hair for retrospective monitoring of cocaine consumption of recreational and dependent users. Results/methodology: Toenail clippings, scrapings and hair samples from recreational and dependent cocaine users were analyzed for cocaine and metabolites. Dependent
Maria Celeiro et al.
Journal of chromatography. A, 1344, 1-14 (2014-04-29)
An effective, simple and low cost sample preparation method based on matrix solid-phase dispersion (MSPD) followed by gas chromatography-mass spectrometry (GC-MS) or gas chromatography-triple quadrupole-mass spectrometry (GC-MS/MS) has been developed for the rapid simultaneous determination of 38 cosmetic ingredients, 25
Samia Yazid et al.
Journal of autoimmunity, 58, 1-11 (2015-01-27)
Annexin-A1 (Anx-A1) is an endogenous anti-inflammatory molecule and while described as a repressor of innate immune responses, the role of Anx-A1 in adaptive immunity, and in particular in T helper (Th) cell responses, remains controversial. We have used a T-cell
Iain M McIntyre et al.
Journal of analytical toxicology, 39(2), 156-159 (2014-11-29)
A 20-year-old man, a college student, became unresponsive in front of his girlfriend. He was known to consume alcohol and take an unknown drug at some point while in attendance at a local music festival earlier in the day/evening. Upon
Anna H Le et al.
PloS one, 9(8), e106013-e106013 (2014-08-26)
Angiogenesis, the formation of new blood vessels, is important for the survival of ovarian transplants and the restoration of ovarian functions. Without angiogenesis, transplanted ovarian tissue becomes more susceptible to tissue damage and necrosis. Administration of analgesics for pain management
Timothy R DeGrado et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(8), 1348-1354 (2014-07-23)
Abnormalities of zinc homeostasis are indicated in many human diseases. A noninvasive imaging method for monitoring zinc in the body would be useful to understand zinc dynamics in health and disease. To provide a PET imaging agent for zinc, we
Marta Maciejewska et al.
Antonie van Leeuwenhoek, 107(2), 519-531 (2014-12-11)
A novel actinobacterium, designated MM109(T), was isolated from a moonmilk deposit collected from the cave 'Grotte des Collemboles' located in Comblain-au-Pont, Belgium. Based on a polyphasic taxonomic approach comprising chemotaxonomic, phylogenetic, morphological, and physiological characterization, the isolate has been affiliated
Tiina Kelkka et al.
Antioxidants & redox signaling, 21(16), 2231-2245 (2014-05-03)
Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by mutations in the phagocyte reactive oxygen species (ROS)-producing NOX2 enzyme complex and characterized by recurrent infections associated with hyperinflammatory and autoimmune manifestations. A translational, comparative analysis of CGD patients and
Feng Zhu et al.
ACS nano, 9(3), 2948-2959 (2015-02-11)
Organometallic halide perovskites CH3NH3PbX3 (X = I, Br, Cl) have quickly become one of the most promising semiconductors for solar cells, with photovoltaics made of these materials reaching power conversion efficiencies of near 20%. Improving our ability to harness the
Naila A Mugheirbi et al.
International journal of pharmaceutics, 471(1-2), 400-411 (2014-06-01)
Itraconazole (ITR) is an antifungal drug with a limited bioavailability due to its poor aqueous solubility. In this study, ITR was used to investigate the impact of nanonisation and solid state change on drug's apparent solubility and dissolution. A bottom
Feng-Ming Ding et al.
Experimental lung research, 41(1), 44-55 (2014-11-15)
We aimed to investigate the activity of regulatory T (Treg) cells in chronic Pseudomonas aeruginosa (PA) lung infection and its influence on effector T-cell responses. C57BL/6 mice were randomly inoculated with PA-laden agarose beads (1 × 10(5) CFU/50 μL) or
Abdulreza Mashroofeh et al.
Chemosphere, 120, 575-583 (2014-12-03)
The levels of 16 polycyclic aromatic hydrocarbons (PAHs) were determined in the liver, kidney, gills and muscle tissues of Persian sturgeon (Acipenser persicus; n=16), and Stellate sturgeon (Acipenser stellatus; n=7) collected from coastal waters of the South Caspian Sea from
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