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Ran Matsudaira et al.
The Journal of rheumatology, 30(6), 1208-1214 (2003-06-05)
To determine the relationships between subtypes of anti-Ki antibodies and clinical manifestations of systemic lupus erythematosus. The cDNA encoding full-length bovine Ki antigens or N- or C-terminal fragments were produced by polymerase chain reaction, and the fragments of Ki antigen
Steinar Uran et al.
Journal of pharmaceutical and biomedical analysis, 39(3-4), 746-751 (2005-06-21)
Sonazoid is a new contrast agent for ultrasound imaging comprising an aqueous suspension of lipid-stabilised perfluorobutane (PFB) gas microbubbles. A respiration-metabolism chamber system was developed to collect exhaled air following intravenous administration of Sonazoid to rats. Analysis of PFB in
Gregory J Riely et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(18), 5731-5734 (2008-09-17)
KRAS mutations are found in approximately 25% of lung adenocarcinomas in Western countries and, as a group, have been strongly associated with cigarette smoking. These mutations are predictive of poor prognosis in resected disease as well as resistance to treatment
Peter M Etaware et al.
PloS one, 15(1), e0209306-e0209306 (2020-01-11)
Food poisoning and environmental pollution are products of excessive chemical usage in Agriculture. In Nigeria, cocoa farmers apply fungicides frequently to control black pod disease (BPD), this practice is life threatening and lethal to the environment. The development of a
Johanna Berkhout et al.
Antimicrobial agents and chemotherapy, 59(2), 1138-1144 (2014-12-10)
To evaluate the in vitro effects of the combination of ceftazidime and avibactam on the MICs of both compounds, checkerboard assays were performed for 81 clinical strains, including 55 Enterobacteriaceae strains (32 Klebsiella pneumoniae, 19 Escherichia coli, 1 Citrobacter freundii
Li Shao et al.
Cell biochemistry and biophysics, 61(2), 377-382 (2011-08-11)
Thyroid stimulating hormone receptor (TSHR) is thought to play a critical role in the pathogenesis of certain thyroid diseases, including Graves' disease (GD), multinodular thyroid goiter (MTG), and Hashimoto's thyroiditis (HT). In order to understand whether single nucleotide polymorphisms in
Mark J Mentrikoski et al.
Applied immunohistochemistry & molecular morphology : AIMM, 22(9), 635-641 (2014-10-04)
Clear-cell renal cell carcinoma (CC-RCC) is the most common primary kidney malignancy, yet this morphology is not unique to renal primary tumors, as clear-cell variants of numerous nonrenal carcinomas of varying lineages exist. Therefore, because of CC-RCC's ability to metastasize
Sajid Jalil et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 8(3), 297-302 (2009-12-02)
Porphyria cutanea tarda (PCT) is the most common of the human porphyrias and results from an acquired deficiency of hepatic uroporphyrinogen decarboxylase (UROD). Some susceptibility factors have been identified; we examined associations among multiple factors in a large cohort of
L Wang et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24(9), e425-e436 (2012-07-12)
Prevalent non-motor symptoms of Parkinson's disease (PD) include gastrointestinal motor impairments and advanced stage PD displays pathological aggregates of α-synuclein in colonic enteric neurons. We previously showed that 12 months old mice overexpressing human wild type (WT) α-synuclein under the
M Coulet et al.
Journal of veterinary pharmacology and therapeutics, 25(2), 89-97 (2002-05-10)
The pharmacokinetics of ibafloxacin, a new veterinary fluoroquinolone antimicrobial agent, was studied following intravenous (i.v.) and oral administration to healthy dogs. The mean absolute bioavailability of ibafloxacin after oral doses of 7.5, 15 and 30 mg/kg ranged from 69 to
Mary Jo Fackler et al.
International journal of cancer, 107(6), 970-975 (2003-11-06)
Little is known about epigenetic silencing of genes by promoter hypermethylation in lobular breast cancers. The promoter methylation status of 5 cancer-related genes (RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist) was evaluated in 2 types of lobular cancers, in situ
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes.
Mathis K Stokke et al.
Cardiovascular research, 86(1), 63-71 (2009-12-19)
To describe the overall role of reduced sarcoplasmic reticulum Ca(2+) ATPase (SERCA2) for Ca(2+) wave development. SERCA2 knockout [Serca2(flox/flox) Tg(alphaMHC-MerCreMer); KO] mice allowing inducible cardiomyocyte-specific disruption of the Serca2 gene in adult mice were compared with Serca(flox/flox) (FF) control mice.
C C Duke et al.
Chemical research in toxicology, 1(5), 294-303 (1988-09-01)
The major metabolites of the carcinogen dibenz[a,j]acridine formed in rodent liver microsomal preparations were trans-3,4-dihydroxy-3,4-dihydrodibenz[a,j]acridine (DBAJAC-3,4-DHD) and dibenz[a,j]acridine 5,6-oxide (DBAJAC 5,6-oxide) [Gill et al. (1987) Carcinogenesis 8, 425-431]. The enantiomers of DBAJAC-3,4-DHD were prepared from the separable diastereoisomeric esters with
Lionel D Lewis et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 13(11), 3302-3311 (2007-06-05)
Increased clearance of drugs, such as oral cyclosporine, that are CYP3A and/or ABCB1 (P-gp/MDR1) substrates was reported in African-American compared with Caucasian patients. We hypothesized that the pharmacokinetics and pharmacodynamics of docetaxel, an i.v. administered cytotoxic and substrate for CYP3A4
J D Nkrumah et al.
Journal of animal science, 85(12), 3170-3181 (2007-08-22)
Feed intake and feed efficiency of beef cattle are economically relevant traits. The study was conducted to identify QTL for feed intake and feed efficiency of beef cattle by using genotype information from 100 microsatellite markers and 355 SNP genotyped
M C Cheung et al.
Journal of lipid research, 27(11), 1135-1144 (1986-11-01)
Two types of A-I-containing lipoproteins are found in human high density lipoproteins (HDL): particles with A-II (Lp(A-I with A-II] and particles without A-II (Lp(A-I without A-II]. We have studied the distribution of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer (CET)
Delphine Détaint et al.
European heart journal, 31(18), 2223-2229 (2010-08-17)
In patients with Marfan syndrome and other type-1 fibrillinopathies, genetic testing is becoming more easily available, leading to the identification of mutations early in the course of the disease. This study evaluates the cardiovascular (CV) risk associated with the discovery
Y B Koo et al.
Endocrinology, 128(5), 2297-2308 (1991-05-01)
The genomic structure of the LH receptor is important to our understanding of its expression mechanisms, functional domains, relationships with other hormone receptors, and evolution. We have isolated four overlapping cosmid clones and six subgenomic clones of the rat LH
Guoliang Yu et al.
Anesthesiology, 133(2), 408-425 (2020-05-21)
Dorsal root ganglion field stimulation is an analgesic neuromodulation approach in use clinically, but its mechanism is unknown as there is no validated animal model for this purpose. The authors hypothesized that ganglion stimulation is effective in reducing pain-like behaviors
S Bailey et al.
European journal of cancer (Oxford, England : 1990), 49(18), 3856-3862 (2013-09-10)
Diffuse intrinsic pontine glioma (DIPG) has a dismal prognosis with no chemotherapy regimen so far resulting in any significant improvement over standard radiotherapy. In this trial, a prolonged regimen (21/28d) of temozolomide was studied with the aim of overcoming O(6)-methylguanine
A A Izzo et al.
Neuroscience, 91(4), 1575-1580 (1999-07-03)
The effect of muscarinic cholinoceptor antagonists was investigated on the ascending neural pathways activated by electrical stimulation in the guinea-pig ileum. For comparison, prejunctional and postjunctional effects of muscarinic cholinoceptor antagonists were also studied on circular smooth muscle. A two-compartment
Neil Rajan et al.
Archives of dermatology, 145(11), 1277-1284 (2009-11-18)
To comprehensively ascertain the extent and severity of clinical features in affected individuals from 2 large families with proven heterozygous mutations in the CYLD locus and to correlate these findings with the 3 appendageal tumor predisposition syndromes (familial cylindromatosis, Brooke-Spiegler
J Marín et al.
British journal of pharmacology, 124(3), 473-478 (1998-07-01)
1. The aim of the present study was to explore the contribution of adrenergic, sensory and nitrergic innervations to the inhibitory effects of the beta2-adrenoceptor agonist clenbuterol on responses to electrical field stimulation (EFS, 200 mA, 0.3 ms, 1-16 Hz
Kathrin Seidemann et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 23(33), 8414-8421 (2005-11-19)
To analyze the association of genetic variation within the tumor necrosis factor (TNF -308 [G-->A]) and lymphotoxin alfa (LT-a +252 [A-->G]) genes with outcome in non-Hodgkin's lymphoma of childhood and adolescence. Genotyping of the TNF -308 (G-->A) and LT-a +252
Alex Iranzo et al.
The Lancet. Neurology, 10(9), 797-805 (2011-08-02)
Serial dopamine transporter (DAT) imaging in patients with Parkinson's disease (PD) and other synucleinopathies shows progressive nigrostriatal dopaminergic dysfunction. Because idiopathic rapid-eye-movement (REM) sleep behaviour disorder (IRBD) can precede the classic symptoms of PD and other synucleinopathies, we postulated that
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or
Lani K Clinton et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 27(6), 1165-1170 (2017-06-13)
The aim of this study was to determine the histopathologic characteristics of patients with endometrial carcinoma with low-volume metastases (micrometastases and isolated tumor cells) compared with macrometastases. We performed a retrospective review of patients with endometrial carcinoma. Among 350 robotic-assisted
Nobuyuki Hamajima et al.
BMC medical genetics, 12, 33-33 (2011-03-04)
Although SLC22A12 258X allele was found among those with hypouricemia, it was unknown that serum uric acid distribution among those with SLC22A12 258X allele. This study examined serum uric acid (SUA) distribution according to SLC22A12 W258X genotype in a general
Shinjiro Mizuguchi et al.
Lung cancer (Amsterdam, Netherlands), 58(3), 369-375 (2007-08-19)
This study aimed to establish the clinical significance of preoperative serum cytokeratin 19 fragment (CYFRA21-1) and Sialyl Lewis(x) (SLX) in patients with stage I non-small cell lung cancer (NSCLC). The study involved 137 patients (87 male, 50 female; median age
M J Nahuis et al.
Human reproduction (Oxford, England), 27(12), 3577-3582 (2012-09-25)
Laparoscopic electrocautery of the ovaries and ovulation induction with gonadotrophins are both second line treatments for women with clomiphene citrate-resistant polycystic ovary syndrome (PCOS). Long-term follow-up after electrocautery versus ovulation induction with gonadotrophins has demonstrated at least comparable chances for
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