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显示 1-30 共 344 条结果 关于 "72-18-4" 范围 论文
Patricia Piña-Sánchez et al.
Medical oncology (Northwood, London, England), 28(4), 1507-1513 (2010-07-28)
Cervical cancer (CC) is the second most common cancer in Mexican women. Human papillomavirus (HPV) infection is necessary but not sufficient for CC development. Furthermore, genetic factors as polymorphisms could be important susceptibility factors. Controversial results regarding TP53 polymorphisms specifically
Jung Yong Eum et al.
Journal of chromatography. A, 460849-460849 (2020-01-14)
Aging refers to the intracellular accumulation of reactive oxygen species that damages proteins, DNA, and lipids. As alterations in lipid metabolism may trigger metabolic disorders and the onset of metabolic diseases, changes in lipid profiles can be closely related to
D Saranath et al.
Gynecologic oncology, 86(2), 157-162 (2002-07-30)
The HPV16/18 code for an oncoprotein-E6, which binds to p53 tumor suppressor protein and degrades the protein via ubiquitination. A common polymorphism of p53 in exon 4 codon 72, resulting in either proline (Pro) or arginine (Arg), affects HPV16/18 E6-mediated
M S Steel et al.
Prostaglandins, leukotrienes, and essential fatty acids, 48(3), 247-251 (1993-03-01)
Male Sprague Dawley rats were fed a butter-enriched diet (50% fat) for 2 weeks which was supplemented orally with 9, 18, 36, or 72 mg/day of ethyl arachidonate for a further 2 weeks. The control group of animals were fed
Kiruthiga Perumal Vijayaraman et al.
Asian Pacific journal of cancer prevention : APJCP, 13(2), 511-516 (2012-04-25)
We investigated the association between polymorphisms in the p53 tumor suppressor gene and breast cancer risk in women especially in the Southern part of India. Genotyping was performed for 50 breast cancer women and 50 controls to determine the status
Heidi C O'Neill et al.
American journal of respiratory cell and molecular biology, 45(2), 323-331 (2011-06-07)
The inhalation of sulfur mustard (SM) causes substantial deposition in the nasal region. However, specific injury has not been characterized. 2-chloroethyl ethyl sulfide (CEES) is an SM analogue used to model injury and screen potential therapeutics. After the inhalation of
Neeraj Jain et al.
Chest, 128(6), 3999-4007 (2005-12-16)
Infection with specific high-risk HPV types 16 and 18 and polymorphism of p53 codon 72 has been strongly associated with the genesis of various neoplasms in humans, but such study in lung cancer is limited and the results are controversial.
Ujjal K Nath et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 118(4), 765-773 (2008-12-04)
High erucic acid rapeseed (HEAR) oil is of interest for industrial purposes because erucic acid (22:1) and its derivatives are important renewable raw materials for the oleochemical industry. Currently available cultivars contain only about 50% erucic acid in the seed
Annette Pantelis et al.
Oncology reports, 17(5), 1243-1248 (2007-03-29)
Epidemiological studies in endemic geographic regions for esophageal squamous cell carcinoma (ESCC) suggested a number of risk factors, including modifications of the p53 tumor suppressor by codon Arg72Pro polymorphism, loss of heterozygosity (LOH) or human papillomavirus type 16 or 18
Zhenning Liu et al.
Inflammation, 38(1), 433-444 (2014-10-24)
The innate immune response is important in paraquat-induced acute lung injury, but the exact pathways involved are not elucidated. The objectives of this study were to determine the specific role of the NLRP3 inflammasome in the process. Acute lung injury
Olivier Richel et al.
The Lancet. Oncology, 14(4), 346-353 (2013-03-19)
Anal cancer is an increasing issue in HIV-positive men who have sex with men (MSM). Screening for its precursor, anal intraepithelial neoplasia (AIN), is subject of discussion. Current treatment options are suboptimum and have not been compared in a prospective
Lotfi Benboubker et al.
The New England journal of medicine, 371(10), 906-917 (2014-09-04)
The combination melphalan-prednisone-thalidomide (MPT) is considered a standard therapy for patients with myeloma who are ineligible for stem-cell transplantation. However, emerging data on the use of lenalidomide and low-dose dexamethasone warrant a prospective comparison of the two approaches. We randomly
M Kinoshita et al.
Clinical and experimental immunology, 143(1), 41-49 (2005-12-22)
Interleukin (IL)-18 is considered to induce exclusively the Th1 immune response but not the Th2 response in the presence of adequate IL-12 stimulation in bacterial infections. However, we demonstrate herein that multiple IL-18 injections to the mice not only enhance
M Reinbold et al.
Oncogene, 27(19), 2788-2794 (2007-11-14)
Codon 72 of human p53 gene is polymorphic, encoding arginine or proline. Here we report construction of a human p53 knock-in (Hupki) mouse encoding the codon 72(pro) variant. The new strain was crossed with the original Hupki mice (codon 72(arg/arg))
S A Larsen et al.
Journal of clinical microbiology, 17(2), 341-345 (1983-02-01)
Both the rapid plasma reagin (RPR) 18-mm circle card test and the toluidine red unheated serum test (TRUST) were designed to be more rapid than the Venereal Disease Research Laboratory slide test for the serodiagnosis of syphilis. The RPR card
Anita A Pinar et al.
Frontiers in pharmacology, 11, 1201-1201 (2020-08-28)
The NLRP3 inflammasome produces interleukin (IL)-1β and IL-18, which when chronically activated by transforming growth factor (TGF)-β1, contribute to fibrosis. The recombinant form of the anti-fibrotic hormone, relaxin (RLX), suppresses the pro-fibrotic influence of TGF-β1 and toll-like receptor (TLR)-4 on
Hwanhui Lee et al.
Analytical and bioanalytical chemistry, 411(21), 5423-5436 (2019-06-05)
It is necessary to characterize and classify neural stem cells (NSCs) and differentiated cells (DCs) for potential use of NSC to treat neurodegenerative diseases. We therefore performed an analysis of NSCs and DCs using gas chromatography mass spectrometry (GC-MS) and
Jinfeng Huang et al.
Dose-response : a publication of International Hormesis Society, 18(2), 1559325820914209-1559325820914209 (2020-05-05)
Radiation biodosimeters are required urgently for fast and accurate evaluation of absorbed dose for irradiated individuals. Lipidomics has appeared as a credible technique for identification and quantification of lipid for researching biomarker of diseases. We performed a lipidomic profile on
Qinjun Zhao et al.
Blood cells, molecules & diseases, 54(1), 90-96 (2014-09-02)
To determine the contribution of the OCT-4 to the pathogenesis of leukemia. Bone marrow (BM) samples obtained from 72 patients with leukemia, and 18 normal healthy subjects were assayed for their OCT-4 expression using both flow cytometry and RT-PCR. OCT-4
X Schneider-Yin et al.
Human heredity, 50(4), 247-250 (2000-04-27)
Acute intermittent porphyria (AIP) is an autosomal dominant disorder caused by decreased activity of porphobilinogen deaminase (PBGD), the third enzyme in the heme biosynthetic pathway. We report the first molecular analysis of PBGD gene mutations in AIP patients of Swiss
Julie L Wang et al.
Nuclear medicine and biology, 37(4), 479-486 (2010-05-08)
The utility of [(18)F]FPBM [2-(2'-((dimethylamino)methyl)-4'-(3-[(18)F]-fluoropropoxy)phenylthio)benzenamine], a selective serotonin transporter (SERT) tracer, and [(18)F]AV-133 [(+)-2-Hydroxy-3-isobutyl-9-(3-fluoropropoxy)-10-methoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine], a selective vesicular monoamine transporter 2 (VMAT2) tracer, were tested in the 6-hydroxydopamine (6-OHDA) unilateral lesioned rat model. Positron emission tomography (PET) imaging of three 6-OHDA
Sanjay Katiyar et al.
Molecular and cellular biochemistry, 252(1-2), 117-124 (2003-10-28)
Infection of high risk human papillomaviruses (HPVs) specifically the types 16 and 18 has been strongly implicated in the development of cervical cancer. The E6 oncoproteins of these high risk HPVs are known to bind and induce degradation of p53
H Zhang et al.
The Journal of urology, 155(1), 163-166 (1996-01-01)
We determined the in vitro effects of cocaine and its 2 major metabolites, benzoylecgonine and ecgonine, on Sertoli cell function. Sertoli cells were isolated from 18 to 20-day-old Sprague-Dawley rats. Sertoli cells were incubated with 4 concentrations (6.25 x 10(-5)
Arvind M Shinde et al.
Breast (Edinburgh, Scotland), 24(1), 18-23 (2014-12-04)
Pathologic complete response (pCR) to neoadjuvant chemotherapy (NCT) is considered a surrogate for improved survival. Platinum-containing NCT, particularly in patients with HER2+ and triple-negative breast cancers (TNBC) may increase pCR rates. Tumor characteristics, pCR rates (no invasive disease in breast
The preliminary study of p53 codon 72 polymorphism and risk of cervical carcinoma in Gabonese women.
Samira Zoa Assoumou et al.
Medical oncology (Northwood, London, England), 32(1), 281-281 (2014-12-17)
Cervical cancer is the leading cause of cancer-related death in Africa and the first most common cancer in Gabonese women due to infection of high-risk human papillomavirus (HPV). However, other cofactors such as genetic factors also come into play. A
Nina Kastner et al.
Frontiers in bioengineering and biotechnology, 8, 502213-502213 (2020-10-31)
Despite major leaps in regenerative medicine, the regeneration of cardiomyocytes after ischemic conditions remains to elucidate. It is crucial to understand hypoxia induced cellular mechanisms to provide advanced treatment options, including the use of stem cell paracrine factors for myocardial
Fan Lin et al.
Archives of pathology & laboratory medicine, 138(8), 1015-1026 (2014-01-21)
Distinction of medullary carcinoma of the large intestine from other cytokeratin (CK) 7⁻/CK20⁻ carcinomas can be challenging when working on a tumor of unknown primary because the majority of medullary carcinomas are negative for CK7, CK20, and CDX2. To investigate
Fengyan Zhao et al.
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 24(5), 588-593 (2010-06-15)
To investigate the expression of telomerase reverse transcriptase (TERT) and cell apoptosis in neonatal rats with hypoxia ischemia brain damage (HIBD). A total of 42 7-day-old SD rats (12-18 g, male or female) were randomly allocated into sham-operation group (n
P M Schiltz et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 8(4), 391-396 (1993-04-01)
This laboratory has purified a unique insulin-like growth factor binding protein (IGFBP-4) that was previously demonstrated to be inhibitory to bone cell proliferation. In this study, the hypothesis that IGFBP-4 is inhibitory to insulin-like growth factor (IGF) actions on cartilage
Susan M Vickers et al.
Inorganic chemistry, 50(7), 2957-2965 (2011-03-12)
By subtly varying crystallization conditions, four distinct cadmium acetate coordination networks with unit cell formulas Cd(87)(H(2)O)(36)(EtOH)(18)(OH)(12)(CH(3)CO(2))(162) (1), Cd(87)(H(2)O)(72)(OH)(12)(CH(3)CO(2))(162) (2), Cd(10)(H(2)O)(6)(OH)(2)(CH(3)CO(2))(18) (3), and Cd(20)(H(2)O)(20)(OH)(4)(CH(3)CO(2))(36) (4) have been isolated. The coordination networks exhibit interesting structural diversity and have been investigated by powder
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