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Yingcai Wang et al.
Bioorganic & medicinal chemistry letters, 20(2), 493-498 (2009-12-17)
Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor for which only short-chain fatty acids (SCFAs) have been reported as endogenous ligands. We describe the discovery and optimization of phenylacetamides as allosteric agonists of FFA2. These novel ligands
Tsukasa Ito et al.
Bioresource technology, 123, 599-607 (2012-09-05)
We investigated the major phylogenetic groups and population size of glucose-, propionate-, and acetate-degrading bacteria in the glucose-degrading anaerobic digester sludge by stable-isotope probing analysis of 16S rRNA (RNA-SIP) with [(13)C(6)]glucose followed by time course analysis of microautoradiography combined with
Nien-Chi Huang et al.
Acta biomaterialia, 28, 55-63 (2015-09-13)
Gene delivery into cells can be facilitated by adding plasmid DNA/transfection reagent complexes in culture medium or pre-adsorbing the complexes on the substrate before cell seeding. Using transfection reagents, however, often causes cytotoxicity. Effective delivery of naked plasmid without any
L Camus et al.
Ecotoxicology and environmental safety, 113, 248-258 (2014-12-19)
Produced water is the main discharge stream from oil and gas production. For offshore activities this water is usually discharged to the marine environment. Produced water contains traces of hydrocarbons such as polycyclic aromatic hydrocarbons as well as alkylphenols, which
Pingxi Xu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(46), 16592-16597 (2014-10-29)
Insect repellents are important prophylactic tools for travelers and populations living in endemic areas of malaria, dengue, encephalitis, and other vector-borne diseases. DEET (N,N-diethyl-3-methylbenzamide) is a 6-decade-old synthetic repellent, which is still considered the gold standard of mosquito repellents. Mosquitoes
Ravi B Marala et al.
European journal of pharmacology, 451(1), 37-41 (2002-09-12)
We evaluated the in vitro pharmacological profile of a novel, potent and highly selective Na(+)/H(+) exchanger-1 (NHE-1) inhibitor, [1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine hydrochloride monohydrate (zoniporide or CP-597,396). The potency and selectivity of zoniporide were determined via inhibition of 22Na(+) uptake by PS-120 fibroblast
R Pignatello et al.
Drug development and industrial pharmacy, 40(11), 1463-1467 (2013-08-16)
This study proposes polymeric micelles produced using new amphiphilic conjugates between amino- or carboxy-mPEG2000 and three different α-lipoamino acids (PEG-LAA). The characterization of these colloidal systems showed CMC values, in the order of 10(-5 )M, that are interesting in the view
Jennifer L Pluznick et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(11), 4410-4415 (2013-02-13)
Olfactory receptors are G protein-coupled receptors that mediate olfactory chemosensation and serve as chemosensors in other tissues. We find that Olfr78, an olfactory receptor expressed in the kidney, responds to short chain fatty acids (SCFAs). Olfr78 is expressed in the
Sangkyu Lee et al.
Journal of proteome research, 12(2), 1007-1013 (2012-12-28)
Protein post-translational modification (PTM) is one of the major regulatory mechanisms that fine-tune protein functions. Undescribed mass shifts, which may suggest novel types of PTMs, continue to be discovered because of the availabilities of more sensitive mass spectrometry technologies and
Atanu Jana et al.
Dalton transactions (Cambridge, England : 2003), 44(1), 359-367 (2014-11-11)
A novel electron rich, tetrathiafulvalene fused zinc porphyrin, (TTF)4PZn, has been newly synthesized and characterized using spectral and electrochemical methods. In spite of the presence of eight t-butyl groups, (TTF)4PZn exhibited appreciable aggregation in solution. Scanning electron microscopic (SEM) imaging
Zhongjiang Jia et al.
Journal of pharmaceutical sciences, 102(3), 960-966 (2013-01-03)
The binding constants (K(b)s) of 17 aryl propionic acid derivatives (APADs) and related compounds with polyvinylpyrrolidone (PVP K30) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64) in aqueous media were determined by affinity capillary electrophoreses (ACE). The K(b)s of APAD to polymers
Yu Jiang et al.
Journal of biomaterials science. Polymer edition, 26(14), 917-930 (2015-07-07)
Series of thermo-sensitive hydrogels (PNAs) based on N-isopropylacrylamide/acrylamide interpenetrating polymer networks were synthesized via in situ free-radical polymerization. Poly (ethylene glycol diacrylate) and poly (ε-caprolactone diacrylate) were synthesized as macro-cross-linkers due to their excellent biocompatibilities. The macro-cross-linkers and hydrogels were
Enhancing Effect of Trachelogenin from Trachelospermi caulis Extract on Intestinal Barrier Function.
Hee Soon Shin et al.
Biological & pharmaceutical bulletin, 38(11), 1707-1713 (2015-08-14)
Trachelospermi caulis is used widely as an herbal medicine in oriental countries to attenuate fever and pain. We wished to reveal the novel function of this herb and its active component on barrier function in intestinal epithelial cells. Monolayers of
Emanuele Brai et al.
The European journal of neuroscience, 40(10), 3436-3449 (2014-09-23)
Notch signalling plays an important role in synaptic plasticity, learning and memory functions in both Drosophila and rodents. In this paper, we report that this feature is not restricted to hippocampal networks but also involves the olfactory bulb (OB). Odour
Konstanze K Julich-Gruner et al.
Clinical hemorheology and microcirculation, 60(1), 13-23 (2015-03-31)
Desamino tyrosine (DAT) and desamino tyrosyl tyrosine (DATT) can be used to functionalize the end groups of water soluble polymers. The phenolic groups may enable physical interactions by π- π interaction and hydrogen bonds, which might lead to the formation
Susumu Muroya et al.
Meat science, 98(4), 726-735 (2014-08-12)
To determine key compounds and metabolic pathways associated with meat quality, we profiled metabolites in postmortem porcine longissimus lumborum (LL) and vastus intermedius (VI) muscles with different aging times by global metabolomics using capillary electrophoresis-time of flight mass spectrometry. Loading
Long Liu et al.
Applied and environmental microbiology, 81(7), 2256-2264 (2015-01-18)
Microbial production of propionic acid (PA), an important chemical building block used as a preservative and chemical intermediate, has gained increasing attention for its environmental friendliness over traditional petrochemical processes. In previous studies, we constructed a shuttle vector as a
B P Espósito et al.
Journal of inorganic biochemistry, 75(1), 55-61 (1999-07-14)
Various divalent rhodium complexes Rh2(L)4 (L = acetate, propionate, butyrate, trifluoroacetate and trifluoroacetamidate) have been found to bind to non-defatted human serum albumin (HSA) at molar ratios about 8:1. The circular dichroism measurements showed that the more liposoluble carboxylates, butyrate
S Daniele et al.
Cell death & disease, 5, e1539-e1539 (2014-11-28)
Therapies that target the signal transduction and biological characteristics of cancer stem cells (CSCs) are innovative strategies that are used in combination with conventional chemotherapy and radiotherapy to effectively reduce the recurrence and significantly improve the treatment of glioblastoma multiforme
Joerg Fleischer et al.
Cell and tissue research, 361(3), 697-710 (2015-03-31)
The precise regulation of digestive and other physiological processes in the gastrointestinal tract in accordance with the food ingested requires continuous monitoring of the luminal content by chemosensory cells. With regard to the detection of chemical compounds in the lumen
Hamed Daemi et al.
Carbohydrate polymers, 92(1), 490-496 (2012-12-12)
A series of aqueous polyurethane dispersions were synthesized by the reaction of polytetramethylene glycol and isophorone diisocyanate, extended with dimethylol propionic acid. Their chemical structures were characterized using FTIR, (1)H NMR, and (13)C NMR, and thermal properties were determined by
Stéphane Dagnas et al.
Journal of food protection, 78(9), 1689-1698 (2015-09-01)
The combined effect of undissociated lactic acid (0 to 180 mmol/liter), acetic acid (0 to 60 mmol/liter), and propionic acid (0 to 12 mmol/liter) on growth of the molds Aspergillus niger, Penicillium corylophilum, and Eurotium repens was quantified at pH
Mariana C F C B Damião et al.
Archiv der Pharmazie, 347(12), 885-895 (2014-10-07)
A novel class of benzo[d][1,3]dioxol-5-ylmethyl alkyl/aryl amide and ester analogues of capsaicin were designed, synthesized, and evaluated for their cytotoxic activity against human and murine cancer cell lines (B16F10, SK-MEL-28, NCI-H1299, NCI-H460, SK-BR-3, and MDA-MB-231) and human lung fibroblasts (MRC-5).
M Denise Robertson et al.
The American journal of clinical nutrition, 82(3), 559-567 (2005-09-13)
Resistant starch may modulate insulin sensitivity, although the precise mechanism of this action is unknown. We studied the effects of resistant starch on insulin sensitivity and tissue metabolism. We used a 4-wk supplementation period with 30 g resistant starch/d, compared
Eduardo Baltierra-Trejo et al.
Bioresource technology, 196, 418-425 (2015-08-12)
The wheat straw lignin-rich fraction (WSLig-RF) can be used as a raw material for the production of metabolites for industrial use if ligninolytic mitosporic fungi are used for its biodegradation into aromatics and short-chain fatty acids (SCFAs, i.e., SCFA2-6). Although
Anong Bintvihok et al.
Toxicon : official journal of the International Society on Toxinology, 47(1), 41-46 (2005-11-22)
This study was undertaken to the study toxic effects of aflatoxins and reducing toxic effects of calcium propionate on performance, hepatic enzyme activities and aflatoxin residues in broilers. Two hundred and seventy 1-day-old hybrid Arbor Acor broiler chickens were fed
Mila Kojadinovic et al.
Journal of the Royal Society, Interface, 10(81), 20121001-20121001 (2013-02-01)
Chemotaxis is one of the best-characterized signalling systems in biology. It is the mechanism by which bacteria move towards optimal environments and is implicated in biofilm formation, pathogenesis and symbiosis. The properties of the bacterial chemosensory response have been described
A Hafeez et al.
Poultry science, 93(7), 1754-1763 (2014-05-28)
Minerals play an important role for growth and bone stability in broilers. Thermal treatment and inclusion of organic acids in feed may affect the mineral absorption and tibial quality in broilers. The study was conducted to investigate the effect of
Junya Zhang et al.
Bioresource technology, 200, 253-261 (2015-10-27)
The effects of microwave pretreatment (MW) on co-digestion of food waste (FW) and sewage sludge (SS) have never been investigated. In this study, a series of mesophilic biochemical methane potential (BMP) tests were conducted to determine the optimized ratio of
Martin Maldonado et al.
Neurochemistry international, 85-86, 31-39 (2015-05-06)
The effect of reserpine on histamine (HA) and tele-methylhistamine (N(τ)-MHA) in hypothalamus and cortex of rats was analyzed and compared to catecholamines. IP injection of reserpine (5 mg/kg) confirmed the effectiveness of reserpine treatment on noradrenaline and dopamine levels. Our in-vitro
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