87-72-9

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Synthesis and in vitro cytotoxicity of haloderivatives of noscapine.

Akhilesh Kumar Verma et al.

Bioorganic & medicinal chemistry, 14(19), 6733-6736 (2006-06-21)

Three haloderivatives of noscapine 2-4 were synthesized chemoselectively and their in vitro cytotoxicity was assessed by MTT assay on U-87 human glioblastoma cell lines. At 50 microM concentration after 72 h, 9-chloronoscapine 2, 9-bromonoscapine 3 (EM011), and 9-iodonoscapine 4 killed

Family of cadmium acetate coordination networks with structurally diverse [Cd4(OAc)9(μ3-OH)]2- secondary building units.

Susan M Vickers et al.

Inorganic chemistry, 50(7), 2957-2965 (2011-03-12)

By subtly varying crystallization conditions, four distinct cadmium acetate coordination networks with unit cell formulas Cd(87)(H(2)O)(36)(EtOH)(18)(OH)(12)(CH(3)CO(2))(162) (1), Cd(87)(H(2)O)(72)(OH)(12)(CH(3)CO(2))(162) (2), Cd(10)(H(2)O)(6)(OH)(2)(CH(3)CO(2))(18) (3), and Cd(20)(H(2)O)(20)(OH)(4)(CH(3)CO(2))(36) (4) have been isolated. The coordination networks exhibit interesting structural diversity and have been investigated by powder

Assessment of stability of drug biomarkers in municipal wastewater as a factor influencing the estimation of drug consumption using sewage epidemiology.

Ivan Senta et al.

The Science of the total environment, 487, 659-665 (2014-01-15)

Stability of the selected urinary biomarkers of six illicit drugs and two therapeutic opioids in municipal wastewater was studied in order to determine errors associated with their possible transformation in the sewer. The stability was assessed in experiments conducted at

Plasma FGF21 displays a circadian rhythm during a 72-h fast in healthy female volunteers.

Birgitte Andersen et al.

Clinical endocrinology, 75(4), 514-519 (2011-04-28)

Fibroblast growth factor (FGF21) is a potent regulator of glucose and lipid metabolism. In rodents, the hepatic expression of FGF21 is controlled by fasting and a circadian regulation, but the physiological role and regulation of FGF21 in humans is not

Response to angiotensin-converting enzyme inhibition is selectively blunted by high sodium in angiotensin-converting enzyme DD genotype: evidence for gene-environment interaction in healthy volunteers.

A Titia Lely et al.

Journal of hypertension, 28(12), 2414-2421 (2010-09-11)

Renin-angiotensin-aldosterone system blockade is a cornerstone in cardiovascular protection. Angiotensin-converting enzyme (ACE)-DD genotype has been associated with resistance to angiotensin-converting enzyme inhibition (ACEi), but data are conflicting. As sodium intake modifies the effect of ACEi as well as the genotype-phenotype

Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study.

Qiujin Shen et al.

The Lancet. Oncology, 13(8), 817-826 (2012-06-29)

Hepatocellular carcinoma (HCC) is prevalent worldwide and improvements in timely and effective diagnosis are needed. We assessed whether measurement of Dickkopf-1 (DKK1) in serum could improve diagnostic accuracy for HCC. We analysed data for patients with HCC, chronic hepatitis B

Systematic and combined endosonographic staging of lung cancer (SCORE study).

Laurence M M Crombag et al.

The European respiratory journal, 53(2) (2018-12-24)

Guidelines recommend endosonography for mediastinal nodal staging in patients with resectable nonsmall cell lung cancer (NSCLC). We hypothesise that a systematic endobronchial ultrasound (EBUS) evaluation combined with an oesophageal investigation using the same EBUS bronchoscope (EUS-B) improves mediastinal nodal staging

G protein-coupled receptor kinases, beta-arrestin-2 and associated regulatory proteins in the human brain: postmortem changes, effect of age and subcellular distribution.

Muriel Grange-Midroit et al.

Brain research. Molecular brain research, 101(1-2), 39-51 (2002-05-15)

G protein-coupled receptor kinases (GRKs) and beta-arrestin-2 play a crucial role in the regulation of neurotransmitter receptors in brain. In this study, GRK2, GRK6, beta-arrestin-2 and associated regulatory proteins (Gbeta proteins and protein phosphatase (PP)-2A) were quantitated in human brains

Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6.

C M Seabury et al.

Genomics, 92(4), 235-245 (2008-07-22)

The mammalian Toll-like receptors (TLRs) recognize invading pathogens, thereafter provoking innate immune responses, whereas peptidoglycan recognition protein 1 (PGLYRP1) is directly microbicidal. The primary objective of this study was to characterize single-nucleotide polymorphisms (SNPs) and insertion-deletion polymorphisms (indels) within bovine

Androgens regulate MMPs and the cellular processes of intimal hyperplasia.

Deidra J H Mountain et al.

The Journal of surgical research, 184(1), 619-627 (2013-06-19)

Testosterone deficiency has been associated with an increased risk of vascular disease. Matrix metalloproteinases (MMPs) have been implicated in vascular remodeling. Our group has demonstrated an association between female hormones and MMP-modulated intimal hyperplasia. In the present study, we investigated testosterone

Xpert MTB/RIF Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study.

Fiona V Cresswell et al.

The Lancet. Infectious diseases, 20(3), 308-317 (2020-01-12)

Tuberculous meningitis accounts for 1-5% of tuberculosis cases. Diagnostic delay contributes to poor outcomes. We evaluated the performance of the new Xpert MTB/RIF Ultra (Xpert Ultra) for tuberculous meningitis diagnosis. In this prospective validation study, we tested the cerebrospinal fluid

Diabetic microvascular complications are not associated with two polymorphisms in the GLUT-1 and PC-1 genes regulating glucose metabolism in Caucasian type 1 diabetic patients.

L Tarnow et al.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 16(8), 1653-1656 (2001-07-31)

An XbaI polymorphism in the gene encoding the glucose transporter, GLUT-1, is associated with development of diabetic nephropathy in Chinese type 2 diabetic patients. In addition, an amino acid variant (K121Q) in the gene encoding the glycoprotein plasma cell differentiating

Semiquantitative analysis of power doppler ultrasonography versus Tc-99m DMSA scintigraphy in diagnostic and severity assessment of acute childhood pyelonephritis.

Hui Zhu et al.

Translational pediatrics, 9(4), 487-495 (2020-09-22)

This study aimed to compare the diagnostic and predictive value of power Doppler ultrasonography (PDU) with Tc-99m dimercaptosuccinic acid (DMSA) renal scintigraphy in pediatric acute pyelonephritis (APN) using a semiquantitative analysis system. A total of 92 children and infants (184

The travails of setting up a living donor liver transplant program: Experience from Pakistan and lessons learned.

Faisal Saud Dar et al.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 21(7), 982-990 (2015-04-22)

Living donor liver transplantation (LDLT) is the only treatment option for patients with end-stage liver disease (ESLD) where cadaveric donors are not available. In developing countries, the inception of LDLT programs remains a challenge. The first successful liver transplantation program

First report of the repellency of 2-tridecanone against ticks.

N W Kimps et al.

Medical and veterinary entomology, 25(2), 202-208 (2010-11-16)

2-Tridecanone and 2-undecanone are both found naturally in the trichomes of wild tomato plants and are important in plant resistance to herbivory. 2-Undecanone is the U.S. Environmental Protection Agency (EPA)-registered active ingredient in the commercially available arthropod repellent, BioUD(®) .

Preoperative serum thyroglobulin concentration as a predictive factor of malignancy in small follicular and Hürthle cell neoplasms of the thyroid gland.

Rok Petric et al.

World journal of surgical oncology, 12, 282-282 (2014-09-13)

Cytologic examination of a fine-needle aspiration biopsy specimen cannot distinguish between benign and malignant follicular or Hürthle cell neoplasms. Serum thyroglobulin (Tg) concentrations are higher in follicular and Hürthle cell carcinomas than in benign follicular or Hürthle cell tumors, but

Exposure to Latent Tuberculosis Treatment during Pregnancy. The PREVENT TB and the iAdhere Trials.

Ruth N Moro et al.

Annals of the American Thoracic Society, 15(5), 570-580 (2018-02-03)

Data are limited regarding the safety of 12-dose once-weekly isoniazid (H, 900 mg) plus rifapentine (P, 900 mg) (3HP) for latent infection treatment during pregnancy. To assess safety and pregnancy outcomes among pregnant women who were inadvertently exposed to study

The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation.

T J Seng et al.

Oncogene, 26(6), 934-944 (2006-07-25)

Identification of tumor suppressor genes (TSG) silenced by methylation uncovers mechanisms of tumorigenesis and identifies new epigenetic tumor markers for early cancer detection. Both nasopharyngeal carcinoma (NPC) and esophageal carcinoma are major tumors in Southern China and Southeast Asia. Through

The reaction of cytochromes c and c2 with the Rhodospirillum rubrum reaction center involves the heme crevice domain.

J Hall et al.

The Journal of biological chemistry, 262(23), 11046-11051 (1987-08-15)

In order to define the interaction domain on Rhodospirillum rubrum cytochrome c2 for the photosynthetic reaction center, positively charged lysine amino groups on cytochrome c2 were modified to form negatively charged carboxydinitrophenyl lysines. The reaction mixture was separated into six

In vivo studies of the SERT-selective [18F]FPBM and VMAT2-selective [18F]AV-133 radiotracers in a rat model of Parkinson's disease.

Julie L Wang et al.

Nuclear medicine and biology, 37(4), 479-486 (2010-05-08)

The utility of [(18)F]FPBM [2-(2'-((dimethylamino)methyl)-4'-(3-[(18)F]-fluoropropoxy)phenylthio)benzenamine], a selective serotonin transporter (SERT) tracer, and [(18)F]AV-133 [(+)-2-Hydroxy-3-isobutyl-9-(3-fluoropropoxy)-10-methoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine], a selective vesicular monoamine transporter 2 (VMAT2) tracer, were tested in the 6-hydroxydopamine (6-OHDA) unilateral lesioned rat model. Positron emission tomography (PET) imaging of three 6-OHDA

The human peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetes.

Maria Luiza Caramori et al.

Diabetes, 52(12), 3010-3013 (2003-11-25)

The peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism has been associated with a decreased risk of type 2 diabetes and a lower albumin excretion rate (AER) in patients with established diabetes. We performed a case-control study aiming to evaluate the

Prognostic value of test(s) for O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation for predicting overall survival in people with glioblastoma treated with temozolomide.

Alexandra McAleenan et al.

The Cochrane database of systematic reviews, 3, CD013316-CD013316 (2021-03-13)

Glioblastoma is an aggressive form of brain cancer. Approximately five in 100 people with glioblastoma survive for five years past diagnosis. Glioblastomas that have a particular modification to their DNA (called methylation) in a particular region (the O6-methylguanine-DNA methyltransferase (MGMT)

Changes in prostaglandin E2 in patients with idiopathic overactive bladder syndrome after botulinum toxin type A treatment: is there a clinical benefit?

Axel Hegele et al.

BMC urology, 14, 85-85 (2014-11-06)

The causality of overactive bladder syndrome (OAB) is still not fully understood. Several studies indicate a significant increase of prostaglandin E2 (PGE2) in patients with OAB. However, in order to clarify whether these compounds can help to objectify the clinical

Pharmacokinetics of aminomethylpropanol in rats following oral and a novel dermal study design.

Shakil A Saghir et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 46(2), 678-687 (2007-10-27)

This study determined the oral and dermal ADME of 2-amino-2-methyl-1-propanol (AMP), a substituted aliphatic alcohol used in a number of industrial and consumer products. Groups of 4 male Fischer 344 rats received either a single bolus oral or dermal dose

[Expression and significance of interleukin-18, 12 and tumor necrosis factor-α in intrahepatic cholestasis of pregnancy].

Ping Jin et al.

Zhonghua fu chan ke za zhi, 46(5), 329-332 (2011-07-08)

To investigate the effect of Interleukin (IL)-18, IL-12 and tumor necrosis factor-α (TNF-α) in hepatic injury in intrahepatic cholestasis of pregnancy (ICP). Sixty-two cases of ICP patients (ICP group), 30 cases of normal pregnant women (control group) and 30 cases

[Effects of rosiglitazone on peroxisome proliferator activated receptor-γ pathway in patients with chronic obstructive pulmonary disease].

Xiao-li Zeng et al.

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 34(10), 743-748 (2012-02-11)

To explore the effects of rosiglitazone on peroxisome proliferator activated receptor-γ (PPAR-γ), nuclear factor-κB and tumor necrosis factor-α (TNF-α) in patients with chronic obstructive pulmonary disease (COPD). From Apr. 2010 to Nov. 2010, 30 patients with acute exacerbations of COPD

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