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Poguang Wang et al.
Journal of the American Society for Mass Spectrometry, 26(10), 1713-1721 (2015-06-28)
N-(2-(Bromomethyl)benzyl)-N,N-diethylethanaminium bromide, that we designate as CAX-B (cationic xylyl-bromide), is presented as a derivatization reagent for increasing sensitivity in mass spectrometry. Because of its aryl bromomethyl moiety, CAX-B readily labels compounds having an active hydrogen. In part, a CAX-tagged analyte
Stacy M Copp et al.
ACS nano, 9(3), 2303-2310 (2015-01-30)
The remarkable precision that DNA scaffolds provide for arraying nanoscale optical elements enables optical phenomena that arise from interactions of metal nanoparticles, dye molecules, and quantum dots placed at nanoscale separations. However, control of ensemble optical properties has been limited
Paola Mura et al.
International journal of pharmaceutics, 475(1-2), 306-314 (2014-09-10)
Transdermal administration of clonazepam, a poorly water-soluble benzodiazepine, is an interesting strategy for overcoming the drawbacks of its oral administration. With this aim, two nano-carrier formulations, based on ultra-deformable liposomes and microemulsions, have been developed to favour clonazepam transdermal delivery.
Joohyung Lee et al.
Langmuir : the ACS journal of surfaces and colloids, 31(44), 11989-11999 (2015-10-21)
Electric charging of colloidal particles in nonpolar solvents plays a crucial role for many industrial applications and products, including rubbers, engine oils, toners, or electronic displays. Although disfavored by the low solvent permittivity, particle charging can be induced by added
Chikako Gemba et al.
Journal of neurophysiology, 113(10), 3720-3735 (2015-04-24)
Histamine receptors are densely expressed in the mesencephalic trigeminal nucleus (MesV) and trigeminal motor nucleus. However, little is known about the functional roles of neuronal histamine in controlling oral-motor activity. Thus, using the whole-cell recording technique in brainstem slice preparations
Naoki Itoh et al.
Journal of chromatography. A, 1404, 141-145 (2015-06-11)
A rapid and mild purification method for nanoparticles using the commercially available monolithic silica disk, MonoSpin(®), was developed. The nanoparticles were purified from a dispersed solution by filtration with the aid of centrifugation at 2290×g for 2min. The purification conditions
Ana Pascual et al.
Biomacromolecules, 16(4), 1169-1178 (2015-03-13)
In this study, a new family of broad-spectrum antimicrobial polycarbonate hydrogels has been successfully synthesized and characterized. Tertiary amine-containing eight-membered monofunctional and difunctional cyclic carbonates were synthesized, and chemically cross-linked polycarbonate hydrogels were obtained by copolymerizing these monomers with a
Hazit Zayas et al.
Organic & biomolecular chemistry, 12(36), 6994-7003 (2014-06-17)
Six novel functional monomers: 4-(4-vinylphenyl)pyridine (M1), 4′-vinylbiphenyl-4-ol (M2), N,N-dimethyl-4′-vinylbiphenyl-3-amine (M3), (4′-vinylbiphenyl-4-yl)methanol (M4), 4′-vinylbiphenyl-4-carboxylic acid (M5) and 4-hydroxy-5-methyl-4′-vinylbiphenyl-3-carboxylic acid (M6), were examined for their ability to imprint theophylline (1). Using a molecular modelling-NMR titration approach, M2 and M6 were predicted to
Antonelle Pardo et al.
Journal of chromatography. A, 1364, 128-139 (2014-09-10)
Molecularly imprinted polymers (MIPs) based on quercetin and synthesized by either bulk, precipitation or suspension polymerization were characterized in terms of size and shape by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). After a study of rebinding protocols
Bingfang Shi et al.
Talanta, 142, 131-139 (2015-05-25)
Nitrogen doping has been a powerful method to modulate the properties of carbon materials for various applications, and N-doped graphene quantum dots (GQDs) have gained remarkable interest because of their unique chemical, electronic, and optical properties. Herein, we introduce a
Yi Yang et al.
Journal of chromatography. A, 1273, 44-48 (2012-12-26)
A sample pretreatment method using acid-base extraction was established for pH-zone-refining counter-current chromatography (CCC) to increase the yield of the target compound. As the most important step, selection of two-phase solvent system for pH-zone-refining CCC should follow some rules. One
High-throughput carotenoid profiling using multivariate curve resolution.
Wehrens R, Carvalho E, Masuero D, et al.
Analytical and Bioanalytical Chemistry (2012)
Jane Kilcoyne et al.
Journal of agricultural and food chemistry, 63(20), 5083-5091 (2015-04-25)
Azaspiracids (AZAs) are marine biotoxins produced by dinoflagellates that can accumulate in shellfish, which if consumed can lead to poisoning events. AZA7-10, 7-10, were isolated from shellfish and their structures, previously proposed on the basis of only LC-MS/MS data, were
Takaki Amamoto et al.
Chemical & pharmaceutical bulletin, 62(7), 649-653 (2014-07-06)
We have developed a general method for controlling molecular functions using a photodegradable hydrogel; gels containing molecules made from such materials are capable of release and activation by light stimulus. As the elimination of molecular leaching from the gel before
Jiwoong Kwon et al.
Scientific reports, 5, 17804-17804 (2015-12-08)
Far-field optical nanoscopy has been widely used to image small objects with sub-diffraction-limit spatial resolution. Particularly, reversible saturable optical fluorescence transition (RESOLFT) nanoscopy with photoswitchable fluorescent proteins is a powerful method for super-resolution imaging of living cells with low light
Mark D Swartzlander et al.
Biomaterials, 41, 79-88 (2014-12-20)
The implantation of non-biological materials, including scaffolds for tissue engineering, ubiquitously leads to a foreign body response (FBR). We recently reported that this response negatively impacts fibroblasts encapsulated within a synthetic hydrogel and in turn leads to a more severe
Yu He et al.
Drug and chemical toxicology, 38(2), 145-151 (2014-05-23)
Tripterygium wilfordii Hook. f. (TW) is a traditional herbal medicine which has been widely used for the treatment of rheumatoid arthritis and other autoimmune diseases. However, adverse reactions of TW such as hepatotoxicity and nephrotoxicity have been frequently reported in
Steven Pham et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt B, 436-444 (2014-09-10)
Castration resistant prostate cancer (CRPC) is often lethal and inevitably develops after androgen ablation therapy. However, in the majority of cases it remains androgen dependent. CRPC tumors have the ability to synthesize their own androgens from cholesterol by engaging in
Luo Fang et al.
Biomedical chromatography : BMC, 29(12), 1937-1940 (2015-05-28)
The quantification of intracranial gefitinib (GEF) exposure is limited owing to the sensitivity of analytical equipment. Although mass spectrometry (MS) is the preferred method because of its high sensitivity, the equipment is not available in many laboratories, especially in developing
Krassimira Yoncheva et al.
International journal of pharmaceutics, 490(1-2), 298-307 (2015-06-01)
The aim of the present study was to develop curcumin loaded cationic polymeric micelles and to evaluate their loading, preservation of curcumin antioxidant activity and intracellular uptake ability. The micelles were prepared from a triblock copolymer consisting of poly(ϵ-caprolactone) and
Ting Zhang et al.
Nanotechnology, 26(14), 145101-145101 (2015-03-17)
Based on the complementary effects of doxorubicin (DOX), all-trans retinoic acid (ATRA) and low molecular weight heparin (LMWH), the combination therapy of DOX, ATRA and LMWH was expected to exert the enhanced anti-tumor effects and reduce the side effects. In
Akiko Ido et al.
Chemosphere, 90(1), 57-64 (2012-09-04)
Polychlorinated biphenyls (PCBs) were mainly used as lubricants and coolants in electrical equipment. However, their chemical stabilities as well as hydrophobic properties caused persistent environmental pollution and damage to human health based on their bioaccumulative property. PCBs are currently targeted
Ana Oliveira et al.
Biomedical chromatography : BMC, 28(9), 1263-1270 (2014-09-23)
Morphine is one of the most effective agents for the control of significant pain, primarily metabolized to morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G). While M6G is a potent opioid agonist, M3G has no opioid action and seems to have a role
Myrna R Rosenfeld et al.
Autophagy, 10(8), 1359-1368 (2014-07-06)
Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment the efficacy of DNA-damaging therapy. The primary objective of this trial was to determine the maximum tolerated dose (MTD) and efficacy of HCQ in combination with radiation therapy (RT) and
Jun He et al.
Analytical chemistry, 84(12), 5236-5242 (2012-05-23)
By combining a novel chiral amino-acid surfactant containing an acryloyl amide tail, a carbamate linker, and a leucine headgroup of different chain lengths with a conventional cross-linker and a polymerization technique, a new "one-pot" synthesis for the generation of amino-acid
Masahito Wakita et al.
Journal of neurophysiology, 114(2), 1109-1118 (2015-05-29)
The effects of heavy water (deuterium oxide, D2O) on GABAergic and glutamatergic spontaneous and evoked synaptic transmission were investigated in acute brain slice and isolated "synaptic bouton" preparations of rat hippocampal CA3 neurons. The substitution of D2O for H2O reduced
Maria Lapteva et al.
Nanoscale, 7(44), 18651-18662 (2015-10-27)
Acne vulgaris is a highly prevalent dermatological disease of the pilosebaceous unit (PSU). An inability to target drug delivery to the PSU results in poor treatment efficacy and the incidence of local side-effects. Cutaneous application of nanoparticulate systems is reported
Mateusz Szalka et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 59, 1-11 (2014-04-22)
HPLC analysis of drug products containing bisoprolol fumarate and lactose revealed the presence of N-formylbisoprolol, which is a final product of the Maillard reaction. Formulations containing secondary amines and reducing carbohydrates are prone to the condensation of amine and carbonyl
Ali Behbahani et al.
Journal of AOAC International, 98(5), 1417-1422 (2015-11-04)
A new method was applied to produce modified nanoporous silica as a novel sorbent for Pb(II) ion SPE from industrial wastewater samples. In this modified method, the produced nanoporous silica has a higher functional group loading, which leads to a
Chen Chen et al.
The journal of adhesive dentistry, 16(2), 169-176 (2014-04-01)
To evaluate the effects of a commercial zirconia primer (Choice or RelyX Unicem) on shear bond strength (SBS) of two different resin composite cements - Choice (a conventional bis-GMA-based resin cement) and RelyX Unicem (self-adhesive resin cement) - to zirconia.
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