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Johana Musso et al.
Analytical and bioanalytical chemistry, 407(5), 1285-1294 (2014-12-20)
Detection of protein biomarkers is of major interest in proteomics. This work reports the analysis of protein biomarkers directly from a biological fluid, human saliva, by surface plasmon resonance imaging coupled to mass spectrometry (SPRi-MS), using a functionalized biochip in
Emmanuelle Vulliet et al.
Environmental science and pollution research international, 21(12), 7512-7521 (2014-03-07)
To collect a complete dataset regarding the occurrence of organic substances in groundwater, this study presents the examination of 66 organic contaminants in the groundwater of overseas departments, including pesticides, pharmaceutical compounds, hormones and some industrial substances. The selective and
Johanna Krippner et al.
Journal of agricultural and food chemistry, 63(14), 3646-3653 (2015-03-31)
Uptake of perfluoroalkyl acids (PFAAs) by maize represents a potential source of exposure for humans, either directly or indirectly via feed for animals raised for human consumption. The aim of the following study was, therefore, to determine the accumulation potential
Arne Trettin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 959, 71-81 (2014-04-29)
Paracetamol (acetaminophen) is a widely used safe analgesic drug when administered at therapeutic doses. Given the chemical reactivity of its phenolic group towards electrophilic species, we assumed that detection of paracetamol metabolites distinctly different from its known phase I metabolite
Sarah K Poznanovic et al.
Mycorrhiza, 25(2), 153-164 (2014-08-06)
Coarse woody debris (CWD) is an important nursery environment for many tree species. Understanding the communities of ectomycorrhizal fungi (ECMF)and the effect of ECMF species on tree seedling condition in CWD will elucidate the potential for ECMF-mediated effects on seedling
Fei Xu et al.
FEMS microbiology letters, 358(1), 98-105 (2014-07-24)
This study investigated inactivation of bacteria with ultraviolet light A irradiation in combination with vitamin K3 as a photosensitizer. Six bacteria including Bacillus cereus, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae, and Escherichia coli suspended in vitamin K3 aqueous
Claudia Dietze et al.
Analytical and bioanalytical chemistry, 407(29), 8735-8743 (2015-09-24)
A fast and straightforward method to prototype microfluidic chip systems for dead-volume-free hyphenation to electrospray-ionisation mass spectrometry is presented. The developed approach based on liquid-phase lithography provides an inexpensive and reliable access to microfluidic chips for MS coupling which can
Nancy D Epsky et al.
Journal of economic entomology, 105(2), 471-479 (2012-05-23)
Tests were conducted that evaluated efficacy of wax matrix bait stations for Ceratitis capitata (Wiedemann) adults in Guatemala. Bait stations were exposed to outdoor conditions to determine effect of weathering on longevity as indicated by bait station age. Results of
Ana Freitas et al.
Journal of the science of food and agriculture, 95(1), 44-52 (2014-05-24)
The industrial processing of pineapple generates a high quantity of by-products. To reduce the environmental impact of these by-products and the inherent cost of their treatment, it is important to characterise and valorise these products, converting them into high added
Francesco De Pascali et al.
Biochemistry, 53(22), 3679-3688 (2014-04-25)
Ischemia-reperfusion injury is accompanied by endothelial hypoxia and reoxygenation that trigger oxidative stress with enhanced superoxide generation and diminished nitric oxide (NO) production leading to endothelial dysfunction. Oxidative depletion of the endothelial NO synthase (eNOS) cofactor tetrahydrobiopterin can trigger eNOS
Eszter Németh et al.
Protein science : a publication of the Protein Society, 23(8), 1113-1122 (2014-06-05)
The nuclease domain of colicin E7 (NColE7) promotes the nonspecific cleavage of nucleic acids at its C-terminal HNH motif. Interestingly, the deletion of four N-terminal residues (446-449 NColE7 = KRNK) resulted in complete loss of the enzyme activity. R447A mutation was reported
Zênia Maria Maciel Lavra et al.
Drug development and industrial pharmacy, 43(1), 42-54 (2016-06-29)
Efavirenz (EFV), a first-line anti-HIV drug largely used as part of antiretroviral therapies, is practically insoluble in water and belongs to BCS class II (low solubility/high permeability). The aim of this study was to improve the solubility and dissolution performances
Joan Eilstein et al.
Archives of toxicology, 88(9), 1681-1694 (2014-03-25)
Skin function is not limited to a physical barrier. According to its total surface area, it is also considered as an extra-hepatic metabolizing organ. In vitro engineered human skins have been developed to replace limited ex vivo normal human skin
Marta Palusinska-Szysz et al.
International journal of molecular sciences, 15(5), 8256-8279 (2014-05-14)
Phosphatidycholine (PC) is the major membrane-forming phospholipid in eukaryotes but it has been found in only a limited number of prokaryotes. Bacteria synthesize PC via the phospholipid N-methylation pathway (Pmt) or via the phosphatidylcholine synthase pathway (Pcs) or both. Here
Hyuck-Soo Kim et al.
Chemosphere, 142, 153-159 (2015-07-04)
Reclaimed tidal land soil (RTLS) often contains high levels of soluble salts and exchangeable Na that can adversely affect plant growth. The current study examined the effect of biochar on the physicochemical properties of RTLS and subsequently the influence on
Chang-Yin Li et al.
Journal of ethnopharmacology, 162, 225-230 (2015-01-13)
Hydroxysafflor yellow A (HSYA), the major active marker compound isolated from Carthamus tinctorius L., has been demonstrated to possess various attractive pharmacological activities. However, there is a lack of information about the complete clinical pharmacokinetic profiles of HSYA following the
Eva Cífková et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1000, 14-21 (2015-07-25)
The characterization of differences among polar lipid classes in tumors and surrounding normal tissues of 20 kidney cancer patients is performed by hydrophilic interaction liquid chromatography (HILIC) coupled to electrospray ionization mass spectrometry (ESI-MS). The detailed analysis of identified lipid
Weidang Wu et al.
Cancer science, 106(6), 747-756 (2015-04-14)
L-type amino acid transporter 1 (LAT1), overexpressed on the membrane of various tumor cells, is a potential target for tumor-targeting therapy. This study aimed to develop a LAT1-mediated chemotherapeutic agent. We screened doxorubicin modified by seven different large neutral amino
Matthew W Vetting et al.
Biochemistry, 54(3), 909-931 (2014-12-30)
The rate at which genome sequencing data is accruing demands enhanced methods for functional annotation and metabolism discovery. Solute binding proteins (SBPs) facilitate the transport of the first reactant in a metabolic pathway, thereby constraining the regions of chemical space
Chung-Wei Yang et al.
PloS one, 9(7), e100576-e100576 (2014-07-23)
Bisphenol A (BPA) is a ubiquitous endocrine disrupting chemical in our daily life, and its health effect in response to prenatal exposure is still controversial. Early-life BPA exposure may impact brain development and contribute to childhood neurological disorders. The aim
Jian Li et al.
Analytical and bioanalytical chemistry, 407(20), 6137-6148 (2015-06-07)
Benzophenone-type UV filters (BPs) are ubiquitous in the environment. Transformation products (TPs) of BPs with suspected toxicity are likely to be produced during disinfection of water by chlorination. To quickly predict the toxicity of TPs, in this study, a novel
Ruijuan Xu et al.
PloS one, 9(12), e114049-e114049 (2014-12-03)
Glycyrrhizin (GL) is a widely used food additive which can cause severe pseudoaldosteronism at high doses or after a long period of consumption. The aim of the present study was to develop a physiologically based pharmacokinetic (PBPK) pharmacodynamic (PD) model
E D N S Abeyrathne et al.
Poultry science, 94(9), 2280-2287 (2015-07-22)
Ovomucoid is well known as a "trypsin inhibitor" and is considered to be the main food allergen in egg. However, the negative functions of ovomucoid can be eliminated if the protein is cut into small peptides. The objectives of this
Ana R Ribeiro et al.
Journal of chromatography. A, 1418, 140-149 (2015-10-04)
The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of 37 micropollutants including Priority Substances (Directive 2013/39/EU), substances of
Marie Meyer-Monath et al.
Talanta, 138, 231-239 (2015-04-13)
Meconium is the first fecal excretion of newborns. This complex accumulative matrix allows assessing the exposure of the fetus to xenobiotics during the last 6 months of pregnancy. To determine the eventual effect of fetal exposure to micropollutants in this
Ewa Sitkiewicz et al.
PloS one, 9(6), e100200-e100200 (2014-06-20)
Oligomeric forms of Aβ peptide are most likely the main synaptotoxic and neurotoxic agent in Alzheimer's disease. Toxicity of various Aβ oligomeric forms has been confirmed in vivo and also in vitro. However, in vitro preparations were found to be
Ian S Westley et al.
Therapeutic drug monitoring, 37(6), 821-826 (2015-03-17)
The polymorphic nature of cytochrome P450 2D6 has made therapeutic drug monitoring of the anti-anginal agent perhexiline a compulsory step in reducing adverse events associated with plasma concentrations above the therapeutic range (0.15-0.60 mg/L). The aim of this study was
Franziska Heydebreck et al.
Environmental science & technology, 49(14), 8386-8395 (2015-06-25)
The production and use of long-chain perfluoroalkyl substances (PFASs) must comply with national and international regulations. Driven by increasingly stringent regulations, their production has been outsourced to less regulated countries in Asia. In addition, the fluoropolymer industry started to use
Zsófia Edit Pápay et al.
Journal of pharmaceutical and biomedical analysis, 117, 210-216 (2015-09-14)
The aqueous solubility of a flavonoid, apigenin, was studied in the presence of first generation cyclodextrins (α-CyD, β-CyD, γ-CyD), ionic and nonionic synthetic derivatives of β-CyD, namely SBE-β-CyD, HP-β-CyD and RM-β-CyD at various physiological pH. The order of solubility enhancement
Yasumi Anan et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(6), 561-564 (2015-06-13)
We demonstrated the complementary use of inductively coupled plasma-mass spectrometry (ICP-MS) and electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-Q-TOF-MS) for the analysis of Se-containing compounds, such as selenate, selenomethionine (SeMet), and trimethylselenonium ion (TMSe), found in biological samples. The sensitivity
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