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Olivier Richoz et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 29(12), 842-845 (2014-01-10)
To investigate the effect of fluorescein on the antimicrobial efficacy of photoactivated riboflavin in corneal collagen cross-linking (CXL) in vitro. The ultraviolet light-A (UVA) absorption by fluorescein and riboflavin in different concentrations was analyzed with a spectrophotometer. The killing rate
He Ren et al.
Cancer letters, 354(1), 172-180 (2014-08-19)
The aim of this study is to investigate the regulatory mechanism of leptin receptors (Ob-R) in pancreatic cancer. We found that the over-expression of hypoxia inducible factor (HIF-1)α and hypoxia up-regulated the expression of Ob-R in pancreatic cancer cells. When
Marco Esposito et al.
European journal of oral implantology, 6(2), 169-179 (2013-08-09)
To compare the clinical effectiveness of two implant systems: Way Milano and Kentron (Geass, Pozzuolo del Friuli, UD, Italy). A total of 64 patients requiring at least two single crowns or partial fixed dental prostheses supported by a maximum of
Shulei Liu et al.
The Canadian journal of cardiology, 30(12), 1689-1699 (2014-11-25)
Micro-RNA 21 (miR-21) has been shown to contribute to cardiac fibrosis in many diseases. In this study we investigated the role of miR-21 in excessive production of collagen in diabetic cardiomyopathy. The proliferation rate of cardiac fibroblasts was analyzed by
Justin W Griffin et al.
The Journal of bone and joint surgery. American volume, 95(23), 2144-2151 (2013-12-07)
When possible, direct repair remains the current standard of care for the repair of peripheral nerve lacerations. In large nerve gaps, in which direct repair is not possible, grafting remains the most viable option. Nerve scaffolds include autologous conduits, artificial
Alice E Stanton et al.
Acta biomaterialia, 96, 310-320 (2019-07-01)
Extracellular matrix (ECM) is comprised of different types of proteins, which change in composition and ratios during morphogenesis and disease progression. ECM proteins provide cell adhesion and impart mechanical cues to the cells. Increasing substrate stiffness has been shown to
Yuzhu Hou et al.
Journal of immunology (Baltimore, Md. : 1950), 193(1), 130-138 (2014-06-08)
The high temperature requirement A1 (HTRA1) is a potent protease involved in many diseases, including rheumatoid arthritis (RA). However, the regulatory mechanisms that control HTRA1 expression need to be determined. In this study, we demonstrated that IFN-γ significantly inhibited the
Yuanming Ouyang et al.
Journal of biomedical nanotechnology, 9(6), 931-943 (2013-07-19)
An ideal nerve scaffold should supply structural guidance and trophic support to facilitate nerve regeneration. Aligned electrospun nanofibers have shown considerable promise for the precise guidance of regenerating axons in vitro and in vivo. Therefore, uniaxially aligned three-dimension (3D) nanofiberous
Alejandro Arboleda et al.
Investigative ophthalmology & visual science, 55(4), 2731-2738 (2014-03-29)
To evaluate the efficacy of coulomb-controlled iontophoresis (CCI) for delivery of riboflavin prior to corneal collagen cross-linking (CXL). The eyes of 20 8-week-old Lewis rats, subject to epithelium-ON (epi-ON, n = 20 eyes) or epithelium-OFF (epi-OFF, n = 20 eyes)
Jonathan E Moore et al.
The British journal of ophthalmology, 98(2), 270-274 (2013-11-30)
Cross-linking of the cornea is usually carried out at a young age as a treatment to manage ectasia. The corneal limbal region contains delicate long-lived stem cells, which could potentially be deleteriously affected by Ultraviolet A (UV-A) radiation. Damage to
Brittany J Behar et al.
Journal of wound care, 23(7), S15-S19 (2014-08-27)
Lower extremity traumatic wounds can be difficult to treat owing to limb ischaemia and large zones of injury. Often, muscle or fasciocutaneous flaps are used in the presence of severe open orthopaedic injuries with soft tissue defects. Sometimes local flaps
James R W Conway et al.
Nature reviews. Cancer, 14(5), 314-328 (2014-04-18)
Integrating biological imaging into early stages of the drug discovery process can provide invaluable readouts of drug activity within complex disease settings, such as cancer. Iterating this approach from initial lead compound identification in vitro to proof-of-principle in vivo analysis
Ken Nakata et al.
Clinical calcium, 23(12), 1731-1739 (2013-12-03)
Meniscus is one of the most important tissues in knee joint from the biomechanical point of view. Meniscus injury is well known to cause osteoarthritis. At moment, there is a limitation of operative repair procedure especially for the meniscus injury
PACK-CXL: defining CXL for infectious keratitis.
Farhad Hafezi et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 30(7), 438-439 (2014-07-02)
Jillian L Astarita et al.
Nature immunology, 16(1), 75-84 (2014-10-28)
In lymph nodes, fibroblastic reticular cells (FRCs) form a collagen-based reticular network that supports migratory dendritic cells (DCs) and T cells and transports lymph. A hallmark of FRCs is their propensity to contract collagen, yet this function is poorly understood.
Sriniwas Sriram et al.
Investigative ophthalmology & visual science, 54(13), 8214-8223 (2013-11-28)
Transforming growth factor β1 (TGFβ1), TGFβ receptor (TGFβR2), and connective tissue growth factor (CTGF) are key regulators of fibrosis in the cornea and in other tissues, including liver, skin, and kidney. We developed an antifibrotic treatment targeting these three critical
Hanne Haslene-Hox et al.
American journal of physiology. Heart and circulatory physiology, 308(1), H18-H28 (2014-11-09)
Elements of the extracellular matrix (ECM), notably collagen and glucosaminoglycans, will restrict part of the space available for soluble macromolecules simply because the molecules cannot occupy the same space. This phenomenon may influence macromolecular drug uptake. To study the influence
Paolo Vinciguerra et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 30(11), 746-753 (2014-11-07)
To report initial clinical results of transepithelial corneal collagen cross-linking with iontophoresis (I-CXL). Twenty eyes of 20 patients diagnosed as having progressive keratoconus who underwent I-CXL were included in this prospective non-randomized clinical study. Corrected distance visual acuity (CDVA), spherical
Jun-Hui Choi et al.
Journal of bioscience and bioengineering, 118(4), 372-377 (2014-04-22)
A thrombolytic protease named kitamase possessing anticoagulant property was purified from edible and medicinal plant Aster yomena (Kitam.) Honda. Kitamase showed a molecular weight of 50 kDa by SDS-PAGE and displayed a strong fibrin zymogram lysis band corresponding to the similar
Takeshi Imamura et al.
Clinical calcium, 23(12), 1767-1773 (2013-12-03)
Intravital optical imaging technique is a promising method that allows us to investigate complex vital phenomena in vivo . In particular, discovery and development of unique fluorescent proteins and smart fluorescent dyes in conjunction with appropriate equipment such as two-photon
Yaowu Hu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(1), 116-120 (2013-12-18)
Domestic cats are one of the most popular pets globally, but the process of their domestication is not well understood. Near Eastern wildcats are thought to have been attracted to food sources in early agricultural settlements, following a commensal pathway
Marco Rossi et al.
Investigative ophthalmology & visual science, 54(6), 4148-4157 (2013-05-25)
To evaluate the effect of corneal deswelling prior to a microkeratome and femtosecond (fs) laser cut and the impact of the fs laser energy settings on the tissue surface and collagen quality. Porcine and human corneas were incubated in THIN-C
Joanne B Tayapad et al.
Current opinion in ophthalmology, 24(4), 288-290 (2013-05-25)
This review presents current data regarding the use of collagen cross-linking in the management of corneal infections. Infectious keratitis can lead to blindness without proper antimicrobial therapy. The disease can still progress and lead to corneal melt despite early detection
Kiyomi Koike et al.
Clinical immunology (Orlando, Fla.), 150(1), 78-87 (2013-12-18)
Inflammation is involved in renal fibrosis, a final common pathway for kidney diseases. To clarify how JAK/STAT/SOCS system was involved in renal fibrosis, UUO was induced in BALB/c or SOCS3(+/-) mice in the presence or absence of JAK inhibitor-incorporated nanoparticle
Amir Sedigh et al.
The Journal of surgical research, 191(2), 455-462 (2014-05-14)
Endothelial glycocalyx regulates the endothelial function and plays an active role in maintaining vascular homeostasis. During ischema and reperfusion, the glycocalyx is rapidly shed into the blood stream. A Corline heparin conjugate (CHC; Corline systems AB, Uppsala, Sweden) consists of
Schwann Cell Autophagy and Necrosis as Mechanisms of Cell Death by Acanthamoeba
Ismael Castelan-Ramirez, et al.
Journal of Separation Science, 9(6), 458-458 (2020)
Ahmad Kutkut et al.
Journal of the International Academy of Periodontology, 15(4), 113-124 (2013-12-25)
The aim of this report was to clinically and radiographically evaluate changes to the hard and soft tissues around implants placed in extraction sockets grafted with medical grade calcium sulfate hemihydrate (MGCSH) mixed with platelet-rich plasma (PRP) and a collagen
Evaluation of cell binding activities of Leptospira ECM adhesins.
Robbins G T, et al.
PLoS Neglected Tropical Diseases, 9(4), e0003712-e0003712 (2015)
Farhad Hafezi et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 30(7), 498-500 (2014-06-04)
To report the long-term clinical outcome of a patient diagnosed as having Terrien marginal degeneration (TMD) who was subjected to corneal collagen cross-linking (CXL) with ultraviolet-A and riboflavin in both eyes. Topographical changes were assessed by high-resolution Scheimpflug imaging and
James E Dixon et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(15), 5580-5585 (2014-04-08)
The ability of materials to define the architecture and microenvironment experienced by cells provides new opportunities to direct the fate of human pluripotent stem cells (HPSCs) [Robinton DA, Daley GQ (2012) Nature 481(7381):295-305]. However, the conditions required for self-renewal vs.
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