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M Touaibia et al.
Mini reviews in medicinal chemistry, 11(8), 695-713 (2011-06-18)
The caffeic acid scaffold, which is abundant in nature, is extremely versatile and is found in a number of biologically active molecules. The purpose of this review is to provide an overview of the pharmacological activity of synthetic caffeic acid
Jérémie Doiron et al.
Bioorganic & medicinal chemistry letters, 19(4), 1118-1121 (2009-01-21)
Novel cinnamoyl and caffeoyl clusters were synthesized by multiple Cu(I)-catalyzed [1,3]-dipolar cycloadditions and their anti-5-lipoxygenase inhibitory activity was tested. Caffeoyl cluster showed an improved 5-lipoxygenase inhibitory activity compared to caffeic acid, with caffeoyl trimer 16 and tetramer 19 showing the
Hiroko Tani et al.
Bioorganic & medicinal chemistry, 18(1), 151-157 (2009-11-28)
The effects of Brazilian green propolis ethanol extract on Cry j1-induced cys-leukotrienes and histamine release from peripheral leukocytes of patients with allergic rhinitis were investigated. One of the key mechanisms for the anti-allergic properties of the extract was revealed to
Wan Cao et al.
Electrophoresis, 36(7-8), 1055-1063 (2015-02-03)
This report describes the use of surfactant-coated graphitized multiwalled carbon nanotubes (SC-GMWNTs) as a novel pseudostationary phase in CE with diode array detection for the determination of phenolic acids and tanshinones in herbal and urine samples. Several parameters influencing the
Li Zhen Zhang et al.
Food chemistry, 174, 495-501 (2014-12-23)
Commonly consumed foxtail millet varieties Jingu28 and Jingu34 were compared in terms of phytochemical composition, antioxidant property, and antiproliferative activity. The cellular antioxidant activity (CAA) was evaluated based on HepG2 cell cultivation. Antiproliferative properties against HepG2 and MDA cell were
Fate of microbial metabolites of dietary polyphenols in rats: is the brain their target destination?
Mattia Gasperotti et al.
ACS chemical neuroscience, 6(8), 1341-1352 (2015-04-22)
Different polyphenol compounds are ingested when consuming a serving of fruits rich in polyphenols, spanning from one-phenol hydroxybenzoic acid to more complex polymeric compounds. Only a minor quantity of the polyphenols (5-10%) is absorbed. The remainder reaches the colon and
Ye Yang et al.
PloS one, 8(3), e58915-e58915 (2013-03-22)
Skin cancer is the most common cancer throughout the world. The epithelial-mesenchymal transition (EMT) and the acquisition of cancer stem cells (CSCs)-like properties emerge as critical steps in the metastasis of human skin cancers. Caffeic acid (CaA) exerts anticarcinogenic effects.
Jéssica V Faria et al.
Food research international (Ottawa, Ont.), 139, 109836-109836 (2021-01-30)
Fruits are widely recognized as sources of biologically active metabolites, such as antioxidant compounds. In this context, fruits commonly consumed in the central Amazonia, especially in its biggest metropolis (Manaus - AM/Brazil), are attractive as potential sources of antioxidant compounds
Xiaojian Huang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 107, 433-439 (2018-08-14)
Osteoarthritis (OA) is a common articular disease that features cartilage loss and destruction. It has been confirmed that inflammation plays major roles in the progression of osteoarthritis. Caffeic acid (CA), a key dietary nutrient commonly found in coffee, has shown
Panpan Guo et al.
Journal of separation science, 38(7), 1156-1163 (2015-01-27)
A sensitive and selective high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry method has been developed and validated for the simultaneous determination of 25 active constituents, including 21 flavonoids and four phenolic acids in the total flavonoids extract
Syed Muhammad Mukarram Shah
BMC complementary and alternative medicine, 15, 299-299 (2015-09-01)
Teucrium stocksianum (T. stocksianum) is one of the important members of the genus Teucrium which contains numerous biologically active compounds. Traditionally, it is used for the treatment of fever, pain, as expectorant and blood purifier. Researchers are trying to discover
Alicia P Cárdenas-Castro et al.
Food chemistry, 360, 130051-130051 (2021-05-22)
Two of the most important Mexican plant-foods are tomato (Solanum lycopersicum L.) and husk tomato (Physalis ixocarpa Brot.). In this study three objectives were followed: i) to evaluate the bioaccessible phenolic compounds (PC) in T and HT during upper gastrointestinal
Elisabeta Baiceanu et al.
Molecules (Basel, Switzerland), 20(6), 11063-11075 (2015-06-18)
Artemisia abrotanum L. ("southernwood") belongs to the Artemisia genus and it is used in traditional medicine for the treatment of a variety of illnesses. Scarce data is available on the chemical composition of this medicinal plant, most research being focused
Canan Sevimli-Gur et al.
Molecular biology reports, 46(4), 3691-3699 (2019-04-21)
Detached leaves of Posidonia oceanica and Zostera marina creating nuisance at the shores were extracted by means of supercritical CO2 enriched with a co-solvent, compared with that of soxhlet extraction. The extracts and their active compounds which are phenylpropanoids (chicoric
Rubén del Barrio-Galán et al.
Journal of the science of food and agriculture, 95(10), 2132-2144 (2014-09-27)
The objective of this work was to study the effect of two Saccharomyces cerevisiae yeast strains with different capabilities of polysaccharide liberation during alcoholic fermentation in addition to subsequent aging on lees with or without oak wood chips as well
Elena Neagu et al.
Metabolites, 13(3) (2023-03-30)
Lately, there has been increased interest in the development of phytochemical alternatives for the prevention and treatment of type 2 diabetes, the alternatives that are able to reduce or prevent glucose absorption by inhibiting digestive enzymes. In this context, this
Yu-Ting Cheng et al.
The Journal of nutritional biochemistry, 25(10), 1045-1057 (2014-07-20)
Ketoprofen is widely used to alleviate pain and inflammation in clinical medicine; however, this drug may cause oxidative stress and lead to gastrointestinal (GI) ulcers. We previously reported that nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role
N Mihailovic-Stanojevic et al.
Plant foods for human nutrition (Dordrecht, Netherlands), 68(3), 235-240 (2013-07-06)
The low incidence of cardiovascular disease in Mediterranean countries leads to an increased interest of the scientific community for the Mediterranean diet. Our aim was to evaluate total phenol and flavonoid contents, antioxidant capacity, free radical scavenging activity and potential
Alper Gökbulut et al.
Natural product communications, 8(4), 475-478 (2013-06-07)
Three Inula species, I. viscosa, I. helenium ssp. turcoracemosa and I. montbretiana, collected from different locations of Anatolia were investigated for their antioxidant and antimicrobial potential, and their total phenolic content and phenolic composition. Antioxidant activities of various extracts of
Comparing antioxidative food additives and secondary plant products-use of different assays
Kranl K, et al.
Food Chemistry, 93(1), 171-175 (2005)
Yue Li et al.
Bioorganic & medicinal chemistry, 19(6), 2074-2083 (2011-02-26)
Cyclooxygenase-1/2 (COX-1/2) and 5-lipoxygenase (5-LOX) are enzymes in two different pathways in the inflammatory process. In the present study, a variety of new nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into nimesulide followed with some structural modifications
María Pilar de Torre et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 129, 110424-110424 (2020-06-22)
Aging-related diseases can be triggered by multiple factors such as oxidative stress. Oxidative stress is an imbalance between free radicals and antioxidants, so today, compounds capable of reducing or neutralizing free radicals are being studied for a therapeutic use. Origanum
Yuli Li et al.
PloS one, 10(5), e0125722-e0125722 (2015-05-06)
Cistanche deserticola is a completely non-photosynthetic parasitic plant with great medicinal value and mainly distributed in desert of Northwest China. Its dried fleshy stem is a crucial tonic in traditional Chinese medicine with roles of mainly improving male sexual function
Luis Bustamante et al.
Journal of agricultural and food chemistry, 65(13), 2793-2804 (2017-03-10)
A novel 'Red Globe' (RG)-derived grape variety, 'Pink Globe' (PG), was described and registered as a new genotype, with earlier ripening and sweeter taste than those of RG. Microsatellite analysis revealed that PG and RG are undifferentiable; however, the PG
Elizabeth L Cordonier et al.
The Journal of nutritional biochemistry, 26(11), 1379-1384 (2015-08-26)
Holocarboxylase synthetase (HLCS) is the sole protein-biotin ligase in the human proteome. HLCS has key regulatory functions in intermediary metabolism, including fatty acid metabolism, and in gene repression through epigenetic mechanisms. The objective of this study was to identify food-borne
Andrzej L Dawidowicz et al.
Journal of food science and technology, 52(7), 4523-4529 (2015-07-04)
The presented paper shows the influence of temperature increase in the range typically used during antioxidant measurements (15-35 °C) on the estimation of antioxidant properties of phenolic compounds (caffeic acid, ferulic acid, gallic acid, trolox, butylhydroxyanisole, butylhydroxytoluene and 2,6-diisopropylphenol) in associating
Yitong Liu et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(5), 461-468 (2013-02-06)
The beneficial or adverse effects of isolated phytochemicals are not always concordant with effects of the botanical dietary supplements from which they were derived. This disparity could be due to interactions between the various phytochemicals present in the whole plant.
Akinobu Tanaka et al.
Molecules (Basel, Switzerland), 19(6), 8238-8260 (2014-06-20)
Besides being a useful building material, bamboo also is a potential source of bioactive substances. Although some studies have been performed to examine its use in terms of the biological activity, only certain parts of bamboo, especially the leaves or
Gang Yu et al.
Bioorganic & medicinal chemistry letters, 20(3), 896-902 (2010-01-05)
A novel class of phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore attached to its C-2, C-3 or C-4 position was designed for evaluation as anti-inflammatory (AI) agents. A number of compounds exhibited a combination of potent in vitro cyclooxygenase-2 (COX-2)
Jun Liu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 51, 310-316 (2012-10-27)
The antioxidant activities of ethanolic extract from edible mushroom Agaricus bisporus (A. bisporus) were evaluated by various methods in vitro and in vivo. In antioxidant assays in vitro, ethanolic extract of A. bisporus was found to have strong reducing power
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