- Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters.
Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters.
Bioorganic & medicinal chemistry letters (2009-01-21)
Jérémie Doiron, Luc H Boudreau, Nadia Picot, Benoît Villebonet, Marc E Surette, Mohamed Touaibia
PMID19152786
摘要
Novel cinnamoyl and caffeoyl clusters were synthesized by multiple Cu(I)-catalyzed [1,3]-dipolar cycloadditions and their anti-5-lipoxygenase inhibitory activity was tested. Caffeoyl cluster showed an improved 5-lipoxygenase inhibitory activity compared to caffeic acid, with caffeoyl trimer 16 and tetramer 19 showing the best 5-lipoxygenase inhibitory activity.