C4032

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关键词:'C4032'

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In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition.

Marc-Antoine Bazin et al.

European journal of medicinal chemistry, 210, 112956-112956 (2020-11-06)

Leishmaniasis constitutes a severe public health problem, with an estimated prevalence of 12 million cases. This potentially fatal disease has a worldwide distribution and in 2012, the fatal Visceral Leishmaniasis (VL) was declared as new emerging disease in Europe, mainly

IgE and IgG4 Epitope Mapping of Food Allergens with a Peptide Microarray Immunoassay.

Javier Martínez-Botas et al.

Methods in molecular biology (Clifton, N.J.), 2578, 219-236 (2022-09-25)

Peptide microarrays are a powerful tool to identify linear epitopes of food allergens in a high-throughput manner. The main advantages of the microarray-based immunoassay are as follows: the possibility to assay thousands of targets simultaneously, the requirement of a low

Epitope Mapping of Food Allergens Using Noncontact Piezoelectric Microarray Printer.

Javier Martínez-Botas et al.

Methods in molecular biology (Clifton, N.J.), 2344, 119-135 (2021-06-12)

Peptide microarrays have been used to study protein-protein interaction, enzyme-substrate profiling, epitope mapping, vaccine development, and immuno-profiling. Unlike proteins, peptides are cheap to produce, and can be produced in a high-throughput manner, in a reliable and consistent procedure that reduces

Characterization of Cep85--a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction

Chen C, et al.

Journal of Cell Science, 128(17) (2015)

Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction.

Canhe Chen et al.

Journal of cell science, 128(17), 3290-3303 (2015-07-30)

Nek2 has been implicated in centrosome disjunction at the onset of mitosis to promote bipolar spindle formation, and hyperactivation of Nek2 leads to the premature centrosome separation. Its activity, therefore, needs to be strictly regulated. In this study, we report

The Arabidopsis thaliana GSK3/Shaggy like kinase AtSK3-2 modulates floral cell expansion

Claisse G, et al.

Plant Molecular Biology, 64(1-2) (2007)

Functional Properties of Dephosphorylated Bovine Whole Casein1

Van Hekken DL and Strange, ED

Journal of Dairy Science, 76(11) (1993)

The physical characteristics and emulsification properties of partially dephosphorylated bovine β-casein.

Noel A McCarthy et al.

Food chemistry, 138(2-3), 1304-1311 (2013-02-16)

Bovine β-casein was purified from phosphocasein by rennet coagulation and cold solubilisation from the resultant curd. β-Casein was then dephosphorylated using potato acid phosphatase. Urea-polyacrylamide gel electrophoresis (PAGE) of partially dephosphorylated β-casein showed a number of bands, depending on the

v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II

Chaar Z, et al.

Test, 281(38) (2006)

Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors.

Marie Lawson et al.

European journal of medicinal chemistry, 123, 105-114 (2016-07-31)

We report here the synthesis, the biological evaluation and the molecular modeling studies of new imidazo[1,2-a]pyridines derivatives designed as potent kinase inhibitors. This collection was obtained from 2-aminopyridines and 2-bromoacetophenone which afforded final compound in only one step. The bioactivity

Roles of OsCKI1, a rice casein kinase I, in root development and plant hormone sensitivity.

Wei Liu et al.

The Plant journal : for cell and molecular biology, 36(2), 189-202 (2003-10-11)

Casein kinases are critical in cell division and differentiation across species. A rice cDNA fragment encoding a putative casein kinase I (CKI) was identified via cDNA macroarray under brassinosteroid (BR) treatment, and a 1939-bp full-length cDNA, OsCKI1, was isolated and

Casein, Dephosphorylated, has been used in studies of modulators of circadian clocks. It has been shown that several molecules can inhibit casein kinase which results in the lenghthening of these clocks.

Chen, Z., et al.

Proceedings of the National Academy of Sciences of the USA (2011)

Post-translational processing of chicken bone phosphoproteins. Identification of bone (phospho)protein kinase.

Y Mikuni-Takagaki et al.

The Biochemical journal, 268(3), 593-597 (1990-06-15)

We have detected a protein kinase which phosphorylates bone phosphoproteins (BPPs) in the detergent extract of the membranous fractions in the periosteal bone strips of 12-day-embryonic-chick tibia. This enzyme, tentatively named BPP kinase, has a catalytic subunit of Mr approximately

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIa as a clock regulatory kinase.

Hirota T., et al.

PLoS Biology, 8 (2010)

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