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关键词:'C5533'
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Arthur Hammer et al.
Investigative ophthalmology & visual science, 55(5), 2881-2884 (2014-03-29)
New corneal cross-linking (CXL) devices are capable of using higher UV-A light irradiances than used in original CXL protocols. The Bunsen-Roscoe law states that a photochemical reaction should stay constant if the delivered total energy is kept constant; however, little
Qian Zhang et al.
The Journal of experimental medicine, 211(13), 2549-2566 (2014-11-26)
DOCK8 mutations result in an inherited combined immunodeficiency characterized by increased susceptibility to skin and other infections. We show that when DOCK8-deficient T and NK cells migrate through confined spaces, they develop cell shape and nuclear deformation abnormalities that do
Marjan M Tajrishi et al.
Biochemical and biophysical research communications, 446(4), 1219-1224 (2014-04-01)
Progressive loss of skeletal muscle mass and strength (sarcopenia) is a major clinical problem in the elderly. Recently, proinflammatory cytokine TWEAK and its receptor Fn14 were identified as key mediators of muscle wasting in various catabolic states. However, the role
Moshe Yamin et al.
International forum of allergy & rhinology, 5(7), 573-582 (2015-04-29)
The mechanism of airway remodeling in chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unknown. We wished to determine whether profibrotic transforming growth factor beta 1 (TGF-β1) and activin A and their downstream signaling proteins are increased in CRSwNP and if
Graysen Vigneux et al.
Bioengineering (Basel, Switzerland), 9(1) (2022-01-21)
The lens of the eye is one of the most radiosensitive tissues. Although the exact mechanism of radiation-induced cataract development remains unknown, altered proliferation, migration, and adhesion have been proposed as factors. Lens epithelial cells were exposed to X-rays (0.1-2
SuRak Eo et al.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 68(1), 104-112 (2014-12-03)
Fifteen rabbits were used to assess the effect of Lipo-PGE1 on neovascularization. Merocel(®) and Alloderm(®) of the same size were implanted separately under the back skin to act as matrices for vessel growth. Lipo-PGE1 was injected intravenously for 2 weeks
Nwanmegha Young et al.
The Annals of otology, rhinology, and laryngology, 123(11), 765-768 (2014-06-21)
The predictability of laryngeal cancer spread is due in part to connective tissue membranes. These membranes function as barriers to cancer and divide the larynx into subunits. The field of laryngeal conservation surgery is based on these concepts. The quadrangular
Shaun D Mendenhall et al.
Plastic and reconstructive surgery, 135(1), 29e-42e (2014-12-30)
Use of acellular dermal matrix in tissue expander breast reconstruction has become a popular adjunct to the total submuscular technique. The question remains as to which matrix, if any, is ideal for breast reconstruction. A randomized trial was conducted to
Colin McGuckin et al.
Nature protocols, 3(6), 1046-1055 (2008-06-10)
This 3-week protocol produces embryonic-like stem cells from human umbilical cord blood (CBEs) for neural differentiation using a three-step system (cell isolation/expansion/differentiation). The CBE isolation produces a highly purified fraction (CD45-, CD33-, CD7-, CD235a-) of small pluripotent stem cells (2-3
Winfried Neuhaus et al.
Frontiers in molecular neuroscience, 10, 149-149 (2017-06-13)
The blood-brain barrier (BBB) is damaged during ischemic insults such as traumatic brain injury or stroke. This contributes to vasogenic edema formation and deteriorate disease outcomes. Enormous efforts are pursued to understand underlying mechanisms of ischemic insults and develop novel
Yan Bi et al.
American journal of physiology. Cell physiology, 307(7), C622-C633 (2014-08-01)
Hepatic stellate cells (HSCs) generate matrix, which in turn may also regulate HSCs function during liver fibrosis. We hypothesized that HSCs may endocytose matrix proteins to sense and respond to changes in microenvironment. Primary human HSCs, LX2, or mouse embryonic
Caroline Forsell et al.
The Annals of thoracic surgery, 98(1), 65-71 (2014-06-03)
The prevalence for thoracic aortic aneurysms (TAAs) is significantly increased in patients with a bicuspid aortic valve (BAV) compared with patients who have a normal tricuspid aortic valve (TAV). TAA rupture is a life-threatening event, and biomechanics-based simulations of the
Maurits L van Montfoort et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(8), 1668-1673 (2014-06-21)
Coagulation factor XI is proposed as therapeutic target for anticoagulation. However, it is still unclear whether the antithrombotic properties of factor XI inhibitors influence atherosclerotic disease and atherothrombosis. Our aim is to investigate whether factor XI antisense oligonucleotides could prevent
Visian toric ICL implantation for residual refractive errors after ICRS implantation and corneal collagen cross-linking in keratoconus.
Elias Jarade et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 29(7), 444-444 (2013-07-04)
Mootaz M Salman et al.
Frontiers in bioengineering and biotechnology, 8, 573775-573775 (2020-10-30)
We describe here the design and implementation of an in vitro microvascular open model system using human brain microvascular endothelial cells. The design has several advantages over other traditional closed microfluidic platforms: (1) it enables controlled unidirectional flow of media
Mark A Castanares et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(5), 805-811 (2014-04-05)
Genetic reporters provide a noninvasive method to monitor and evaluate a population of cells. The ideal properties of a gene reporter-probe system include biocompatibility, lack of immunogenicity, low background expression or signal, and high sensitivity of detection. The prostate-specific membrane
Shusaku Hayashi et al.
JCI insight, 7(23) (2022-10-28)
Acute and chronic intestinal inflammation is associated with epithelial damage, resulting in mucosal wounds in the forms of erosions and ulcers in the intestinal tract. Intestinal epithelial cells (IECs) and immune cells in the wound milieu secrete cytokines and lipid
M Özgen Öztürk-Öncel et al.
Materials science & engineering. C, Materials for biological applications, 126, 112147-112147 (2021-06-05)
Low proliferation capacity of corneal endothelial cells (CECs) and worldwide limitations in transplantable donor tissues reveal the critical need of a robust approach for in vitro CEC growth. However, preservation of CEC-specific phenotype with increased proliferation has been a great
Steinunn Sara Helgudottir et al.
Molecular neurobiology, 56(4), 2362-2374 (2018-07-22)
Ferroportin is the only known iron exporter, and its regulation seems to be controlled at both transcriptional, post-transcriptional, and post-translational levels. The objective of the current work was to investigate how cellular iron status affects the expression of the ferroportin
Sirintip Chaichalotornkul et al.
Biochemical and biophysical research communications, 456(1), 92-97 (2014-12-03)
Secondhand cigarette smoke exposure (SSE) has been linked to carcinogenic, oxidative, and inflammatory reactions. Herein, we investigated whether premature skin aging could be induced by SSE in a rat model, and assessed the cytoplasmic translocation of high mobility group box
Arianna Carolina Rosa et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 308-316 (2014-09-04)
Pulmonary fibrosis, a progressive and lethal lung disease characterized by inflammation and accumulation of extracellular matrix components, is a major therapeutic challenge for which new therapeutic strategies are warranted. Cyclooxygenase (COX) inhibitors have been previously utilized to reduce inflammation. Histamine
High fluence iontophoretic corneal collagen cross-linking: in vivo OCT imaging of riboflavin penetration.
Paolo Vinciguerra et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 29(6), 376-377 (2013-06-07)
Georgios Kotsakis et al.
The Journal of oral implantology, 40(6), 690-698 (2014-12-17)
It has been documented that after every extraction of one or more teeth, the alveolar bone of the respective region undergoes resorption and atrophy. Therefore, ridge preservation techniques are often employed after tooth extraction to limit this phenomenon. The benefits
Tomohiro Tanaka et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(4), 1370-1379 (2014-01-24)
Formation of proper neuromuscular connections is a process coordinated by both motoneuron-intrinsic and target-dependent programs. Under these programs, motoneurons innervate target muscles, escape programmed cell death during fetal development, and form neuromuscular junctions (NMJ). Although a number of studies have
Anastasios John Kanellopoulos
Journal of refractive surgery (Thorofare, N.J. : 1995), 29(7), 504-505 (2013-07-04)
To report a novel application of collagen cross-linking (CXL) in refractive astigmatic enhancement of previously performed astigmatic keratotomy. A 28-year-old woman with prior history of bioptics correction of high myopic astigmatism with femtosecond laser-assisted astigmatic keratotomy followed by topography-guided LASIK
Di Tang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 46(6), 2460-2470 (2018-05-10)
Regional hypoxia promptly develops after trauma because of microvascular injury and increased oxygen consumption. This acute hypoxia plays a positive role in early skin wound healing. One of the mechanisms underlying the beneficial effects of acute hypoxia on wound healing
Solfrid J Sagstad et al.
American journal of physiology. Heart and circulatory physiology, 308(1), H29-H38 (2014-11-02)
Collagen and glycosaminoglycans (GAGs) constituting the ECM may limit the space available and thus exclude macromolecules from a fraction of the interstitial fluid (IF) phase. This exclusion phenomenon is of importance for transcapillary fluid and solute exchange. The purpose of
Emily N Sevcik et al.
Current protocols in cell biology, 75, 10-10 (2017-06-20)
The cell microenvironment plays an important role in many biological processes, including development and disease progression. Key to this is the extracellular matrix (ECM), a complex biopolymer network serving as the primary insoluble signaling network for physical, chemical, and mechanical
Eun Young Hwang et al.
Biochemical and biophysical research communications, 449(4), 425-431 (2014-05-27)
Periostin appears to be a unique extracellular protein secreted by fibroblasts that is upregulated following injury to the heart or changes in the environment. Periostin has the ability to associate with other critical extracellular matrix (ECM) regulators such as TGF-β
Atul Katarkar et al.
Biochemical and biophysical research communications, 456(3), 707-713 (2014-12-20)
Heat shock protein-47 (Hsp-47) is exclusive collagen specific molecular chaperone involved in the maturation, processing and secretion of procollagen. Hsp-47 is consistently upregulated in several fibrotic diseases. Till date there is no potential antifibrotic small molecule drug available and Hsp-47
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