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Paola Devoto et al.
Addiction biology, 19(4), 612-622 (2013-01-08)
The dopamine-beta-hydroxylase inhibitor nepicastat has been shown to reproduce disulfiram ability to suppress the reinstatement of cocaine seeking after extinction in rats. To clarify its mechanism of action, we examined the effect of nepicastat, given alone or in association with
Jiejun Shi et al.
Nucleic acids research, 42(15), 9730-9739 (2014-08-02)
ATP-dependent chromatin remodeling complexes regulate nucleosome organizations. In Drosophila, gene Brm encodes the core Brahma complex, the ATPase subunit of SWI/SNF class of chromatin remodelers. Its role in modulating the nucleosome landscape in vivo is unclear. In this study, we
Guiling Zhao et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(34), E4792-E4801 (2015-08-12)
In ventricular myocytes, the physiological function of stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum (ER/SR) Ca(2+) sensor, is unclear with respect to its cellular localization, its Ca(2+)-dependent mobilization, and its action on Ca(2+) signaling. Confocal microscopy was used to
Alireza Valanezhad et al.
Journal of materials science. Materials in medicine, 26(7), 212-212 (2015-07-17)
Hydroxyapatite (HAp) coating was formed on zinc phosphate (Ti-Zn-PO4) coated Ti plates by hydrothermal treatment in CaCl2 solution at 200 °C for 12 h. Uniform surface coverage of the fabricated HAp coating was obtained by this method. SEM-EDX analysis of the adhesion
Mohamed Zeriouh et al.
Clinical transplantation, 29(4), 383-392 (2015-02-11)
Lung transplantation (LTx) remains the definitive treatment for end-stage lung failure, whereas chronic obstructive pulmonary disease (COPD) represents one of the main diagnoses leading to the indication for a transplant. We sought to assess long-term outcomes after LTx in patients
N Colin Heath et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(26), 8800-8812 (2014-06-27)
The cerebellum receives sensory information by mossy fiber input from a multitude of sources that require differential signal processing. A compartmentalization of function begins with the segregation of mossy fibers across 10 distinct lobules over the rostrocaudal axis, with tactile
An Phan Duy et al.
Developmental neuroscience, 37(4-5), 417-427 (2015-03-21)
Several lines of evidence demonstrate that inhaled nitric oxide (iNO) not only acts locally on the pulmonary vasculature but also has remote effects on the mature and developing brain under basal or pathological conditions by modulating cerebral blood flow and
Ruben D Arroyo-Olarte et al.
PLoS biology, 13(11), e1002288-e1002288 (2015-11-14)
The major membrane phospholipid classes, described thus far, include phosphatidylcholine (PtdCho), phosphatidylethanolamine (PtdEtn), phosphatidylserine (PtdSer), and phosphatidylinositol (PtdIns). Here, we demonstrate the natural occurrence and genetic origin of an exclusive and rather abundant lipid, phosphatidylthreonine (PtdThr), in a common eukaryotic
Qingqing Li et al.
Journal of neuroimmunology, 288, 1-12 (2015-11-05)
Immune activation can exert multiple effects on synaptic transmission. Our study demonstrates the influence of neonatal vaccination on hippocampal synaptic plasticity in rats under normal physiological conditions. The results revealed that neonatal BCG vaccination enhanced synaptic plasticity. In contrast, HBV
Courtney Sobieski et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(31), 11105-11117 (2015-08-08)
Neuron-astrocyte interactions are critical for proper CNS development and function. Astrocytes secrete factors that are pivotal for synaptic development and function, neuronal metabolism, and neuronal survival. Our understanding of this relationship, however, remains incomplete due to technical hurdles that have
Daniela A Parodi et al.
Reproductive toxicology (Elmsford, N.Y.), 54, 66-75 (2014-12-30)
Early life exposure to estrogens and estrogen like contaminants in the environment is thought to contribute to the early onset of puberty and consequently increases the risk of developing breast cancer in the exposed female. The results of this study
Luciana Meli et al.
Stem cell research, 13(1), 36-47 (2014-05-13)
We developed a three-dimensional (3D) cellular microarray platform for the high-throughput (HT) analysis of human neural stem cell (hNSC) growth and differentiation. The growth of an immortalized hNSC line, ReNcell VM, was evaluated on a miniaturized cell culture chip consisting
Somnath Mukherjee et al.
Journal of molecular biology, 427(16), 2707-2725 (2015-07-15)
Reversible, high-affinity immobilization tags are critical tools for myriad biological applications. However, inherent issues are associated with a number of the current methods of immobilization. Particularly, a critical element in phage display sorting is functional immobilization of target proteins. To
Marilena Briglia et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 37(2), 768-778 (2015-09-12)
The JAK1/JAK2 tyrosine kinase inhibitor ruxolitinib is widely used for the treatment of myeloproliferative neoplasm-associated myelofibrosis and other malignancies. Most important side effects include anemia. A common cause of anemia is accelerated suicidal death of erythrocytes or eryptosis, which is
Terry W Moody et al.
Journal of molecular neuroscience : MN, 56(3), 663-672 (2015-03-13)
Cholecystokinin (CCK) receptors are G-protein coupled receptors (GPCR) which are present on lung cancer cells. CCK-8 stimulates the proliferation of lung cancer cells, whereas the CCK2R receptor antagonist CI-988 inhibits proliferation. GPCR for some gastrointestinal hormones/neurotransmitters mediate lung cancer growth
Zhantao Han et al.
Water research, 70, 394-403 (2015-01-03)
This paper discusses the sorbent properties of magnetic activated carbons and biochars produced by wet impregnation with iron oxides. The sorbents had magnetic susceptibilities consistent with theoretical predictions for carbon-magnetite composites. The high BET surface areas of the activated carbons
Lenea Nørskov-Lauritsen et al.
FEBS letters, 589(5), 588-597 (2015-01-27)
Investigation of post-translational modifications of receptor proteins is important for our understanding of receptor pharmacology and disease physiology. However, our knowledge about post-translational modifications of class C G protein-coupled receptors and how these modifications regulate expression and function is very
Liliya Vinarova et al.
Food & function, 6(4), 1319-1330 (2015-03-17)
Quillaja saponin extracts are known to reduce plasma cholesterol levels in humans. Here we study the mechanism of this effect with Quillaja Dry saponin extract (QD). In vitro model of triglyceride lipolysis is used to quantify the effect of QD
HyeSook Youn et al.
Journal of cellular biochemistry, 116(11), 2504-2516 (2015-04-23)
Frequent relapse and spreading of tumors during radiotherapy are principal obstacles to treatment of non-small cell lung cancer (NSCLC). In this study, we aimed to investigate how macrophage migration inhibitory factor (MIF) which is expressed at high levels in metastatic
Tetsuhiko Yasuno et al.
Biochemical and biophysical research communications, 448(2), 175-181 (2014-05-02)
Carnitine palmitoyltransferase II (CPT II) deficiency is an inherited disorder involving β-oxidation of long-chain fatty acids (FAO), which leads to rhabdomyolysis and subsequent acute renal failure. The detailed mechanisms of disease pathogenesis remain unknown; however, the availability of relevant human
Maryam Khodai-Kalaki et al.
mBio, 6(3), e00679-e00679 (2015-06-06)
Burkholderia cenocepacia causes opportunistic infections in plants, insects, animals, and humans, suggesting that "virulence" depends on the host and its innate susceptibility to infection. We hypothesized that modifications in key bacterial molecules recognized by the innate immune system modulate host
Frank Richter et al.
Annals of neurology, 76(1), 43-53 (2014-05-07)
Brain damage and ischemia often trigger cortical spreading depression (CSD), which aggravates brain damage. The proinflammatory cytokine tumor necrosis factor (TNF) is significantly upregulated during brain damage, but it is unknown whether TNF influences spreading depression in cerebral cortex in
James M Kuczmarski et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(5), 482-491 (2014-07-26)
The purpose of this investigation was to determine the effect of 4 wk of voluntary wheel running on cardiac performance in the 5/6 ablation-infarction (AI) rat model of chronic kidney disease (CKD). We hypothesized that voluntary wheel running would be
Shefeeq M Theparambil et al.
Glia, 63(9), 1581-1594 (2015-03-31)
Cytosolic H(+) buffering plays a major role for shaping intracellular H(+) shifts and hence for the availability of H(+) for biochemical reactions and acid/base-coupled transport processes. H(+) buffering is one of the prime means to protect the cell from large
Michaela Stolz et al.
Pflugers Archiv : European journal of physiology, 467(10), 2121-2140 (2015-01-17)
The P2X7 receptor (P2X7R) is a ligand-gated ion channel that conducts Na(+), K(+), and Ca(2+) when activated by extracellular ATP. In various cell types, such as secretory epithelia, the P2X7R is co-expressed with Ca(2+)-dependent Cl(-) channels of the TMEM16/anoctamin family.
Sung-Hyun Kang et al.
Naunyn-Schmiedeberg's archives of pharmacology, 388(7), 773-780 (2015-02-17)
Intravesical administration of the cytotoxic drug doxorubicin is a common treatment for superficial carcinoma of the bladder, but it is associated with significant urological adverse effects. The aim of this study was to identify doxorubicin-induced changes in the local mechanisms
Alexa Sadier et al.
BMC evolutionary biology, 15, 129-129 (2015-07-03)
Only a handful of signaling pathways are major actors of development and responsible for both the conservation and the diversification of animal morphologies. To explain this twofold nature, gene duplication and enhancer evolution were predominantly put forth as tinkering mechanisms
Chengliang Li et al.
Journal of environmental sciences (China), 25(3), 466-472 (2013-08-08)
The aggregation of multi-walled carbon nanotubes (MWCNTs) in the aqueous phase not only inhibits their extensive utilization in various aspects but also dominates their environmental fate and transport. The role of surfactants at low concentration in the aggregation of MWCNTs
Hironori Nakagami et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 37(7), 629-635 (2014-03-14)
Diabetes mellitus, hypertension and metabolic syndrome are major risk factors for the occurrence of cardiovascular events. In this study, we used spontaneous hypertensive rat (SHR)/NDmcr-cp (cp/cp) (SHRcp) rats as a model for metabolic syndrome to examine the effects of dipeptidyl
Werner E G Müller et al.
Chembiochem : a European journal of chemical biology, 16(9), 1323-1332 (2015-04-15)
Studies indicate that mammalian bone formation is initiated at calcium carbonate bioseeds, a process that is driven enzymatically by carbonic anhydrase (CA). We show that amorphous calcium carbonate (ACC) and bicarbonate (HCO3 (-) ) cause induction of expression of the
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