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E Bergamini et al.
Experimental and molecular pathology, 46(1), 114-122 (1987-02-01)
A dramatic increase in the plasma glucagon/insulin ratio can be induced by treating fasted rats with antilipolytic drugs (e.g., with 3,5-dimethylpyrazole, 12 mg/kg body wt). These hormone changes are the physiologically appropriate response to a rapid decrease in free fatty
E Bergamini et al.
Experimental and molecular pathology, 59(1), 13-26 (1993-08-01)
The effect of the antilipolytic agent 3,5-dimethylpyrazole (DMP) on liver autophagy and protein degradation was studied on male young adult rats (200 g body wt) of the Sprague-Dawley strain by electron microscopy and short-term single-pass liver perfusion and HPLC amino
N Sundaraganesan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 74(3), 788-797 (2009-09-05)
In the present study, structural properties of 3,5-dimethylpyrazole (3,5-DMP) have been studied extensively utilizing density functional theory (DFT) employing B3LYP exchange correlation. The Fourier transform infrared (solid phase and gas phase) and Fourier transform Raman spectra of 3,5-DMP were recorded.
C Redekopp et al.
Journal of endocrinological investigation, 7(4), 277-281 (1984-08-01)
The inhibitory and stimulatory effects of somatostatin analogues on growth hormone secretion have been studied in the sheep. Plasma immunoreactive growth hormone (GH) was stimulated by the iv administration of the antilipolytic compound 3,5-dimethylpyrazole and was followed by infusion of
Effects of antilipolytic agents on peroxisomal beta-oxidation of fatty acids in rat liver.
T Locci-Cubeddu et al.
Biochemical pharmacology, 32(11), 1807-1809 (1983-06-01)
The regulation of liver protein degradation by aminoacids in vivo. Effects of glutamine and leucine.
E Bergamini et al.
Archives of physiology and biochemistry, 103(4), 512-515 (1995-08-01)
The effects in vivo of the two major in vitro regulatory aminoacids, leucine and glutamine, on liver protein degradation were explored in male young adult Sprague Dawley rats. Protein degradation was stimulated by the injection of the antilipolytic drug 3,5
V Krishnakumar et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 79(5), 1959-1968 (2011-06-28)
In this work, the experimental and theoretical vibrational spectra of pyrazole (PZ) and 3,5-dimethyl pyrazole (DMP) have been studied. FTIR and FT-Raman spectra of the title compounds in the solid phase are recorded in the region 4000-400 cm(-1) and 4000-50
Gabriella Cavallini et al.
Autophagy, 3(1), 26-27 (2006-09-12)
Autophagy is a major intracellular degradation/recycling system ubiquitous in eukaryotic cells. It contributes to the turnover of cellular components by delivering portions of the cytoplasm and organelles to lysosomes, where they are digested. Starvation-induced autophagy is required for maintaining an
P Masiello et al.
Metabolism: clinical and experimental, 51(1), 110-114 (2002-01-10)
This study intended to test the hypothesis that intracellular lipolysis in the pancreatic beta cells is implicated in the regulation of insulin secretion stimulated by nutrient secretagogues or cyclic adenosine monophosphate (cAMP) agonists. Indeed, although lipid signaling molecules were repeatedly
E Bergamini et al.
The American journal of physiology, 266(1 Pt 1), G118-G122 (1994-01-01)
Regulation of liver macroautophagy and protein degradation by hormones and direct regulatory amino acids were studied in male 2-mo-old Sprague-Dawley albino rats with the use of the antilipolytic agent 3,5'-dimethylpyrazole (DMP; 12 mg/kg body wt ip) as a stimulatory agent.
Alessandra Del Roso et al.
Experimental gerontology, 38(5), 519-527 (2003-05-14)
Autophagy is a universal, highly regulated mechanism responsible for the degradation of long-lived proteins, cytomembranes and organelles during fasting and may be the cell repair mechanism that mediates the anti-ageing effects of calorie restriction (Bergamini and Gori, 1995). The function
Ishita Banerjee et al.
Dalton transactions (Cambridge, England : 2003), 42(5), 1879-1892 (2012-11-23)
Four dinuclear bis(μ-Cl) bridged copper(II) complexes, [Cu(2)(μ-Cl)(2)(L(X))(2)](ClO(4))(2) (L(X) = N,N-bis[(3,5-dimethylpyrazole-1-yl)-methyl]benzylamine with X = H(1), OMe(2), Me(3) and Cl(4)), have been synthesized and characterized by the single crystal X-ray diffraction method. In these complexes, each copper(II) center is penta-coordinated with square-pyramidal
[Comparative study of analgesics].
F Castro González et al.
Practica odontologica, 7(2), 30-32 (1986-02-01)
J. Chem. Soc. Pak., 14, 125-125 (1992)
Mayreli Ortiz et al.
Dalton transactions (Cambridge, England : 2003), (27)(27), 3559-3566 (2008-07-03)
Two fluorescent ligands, 3,5-dimethyl-4-(6'-sulfonylammonium-1'-azonaphthyl)pyrazole (dmpzn, 1) and 3,5-dimethyl-4-(4'-N,N'-dimethylaminoazophenyl)pyrazole (dmpza, 2) were obtained by condensation of ketoenolic derivatives with hydrazine. 1 and 2 formed the novel dinuclear complexes [(H(2)O)(3)ClRu(micro-L)(2)RuCl(H(2)O)(3)] (3 or 4) and [(H(2)O)(NO)Cl(2)Ru(micro-L)(2)RuCl(2)(NO)(H(2)O)] (6 or 7) (where L 1 =
J. Chem. Soc., Dalton Trans., 3625-3625 (1993)
A Del Roso et al.
Acta biologica Hungarica, 42(1-3), 87-99 (1991-01-01)
In this study, we explored the changes in the rate of protein degradation in liver cells in vivo, using a method based on the physiological stimulation of liver autophagy. Male albino rats 1, 2, 6, 12 and 24 months old
Effect of dietary restriction on the age-related changes in hormone-regulated protein breakdown.
A Del Roso et al.
Aging (Milan, Italy), 3(4), 407-408 (1991-12-01)
Alessio Donati et al.
Rejuvenation research, 9(3), 408-412 (2006-07-25)
Reduction of oxidative stress within mitochondria is a major focus and important part in the SENS agenda. The age-related accumulation of mitochondria rich in oxidatively altered DNA may be a biomarker of malfunctioning and increased oxidative stress. Macroautophagy is the
[Information from the Soviet Toxicology Center].
Gigiena truda i professional'nye zabolevaniia, (10)(10), 56-57 (1981-10-01)
J M Orza et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 56A(8), 1469-1498 (2000-07-25)
The infrared (IR) and Raman spectra of 3,5-dimethylpyrazole have been recorded in the vapor, liquid (melt and solution) and solid states. Two deuterated derivatives, C5H7N-ND and C5D7N-NH, were also studied in solid state and in solutions. Instrumental resolution was relatively
Journal of Organometallic Chemistry, 443, 221-221 (1993)
C Redekopp et al.
Journal of endocrinological investigation, 3(3), 237-241 (1980-07-01)
To investigate the suppressive effect of somatostatin on growth hormone secretion, a consistent, potent stimulus to growth hormone release is required. The antilipolytic compound 3,5-dimethylpyrazole (DMP) gave a rapid rise in plasma immunoreactive growth hormone following iv administration to fasting
T Locci Cubeddu et al.
Biochimica et biophysica acta, 839(1), 96-104 (1985-03-29)
The mechanisms involved in the inhibitory effects of antilipolytic agents on rat liver peroxisomal fatty acid oxidative activity have been explored. Treatment of fasting rats with antilipolytic drugs (either 3,5-dimethylpyrazole (12 mg/kg body weight) or Acipimox (25 mg/kg body weight]
Hasnae Bendaha et al.
European journal of medicinal chemistry, 46(9), 4117-4124 (2011-07-05)
The synthesis and extensive biological study of two new tridentates ligands based on pyrazole and triazole are described. The antifungal activity against the budding yeast cells of the newly synthesized compounds was determined. These compounds were toxic to yeast cells.
Rupam Sarma et al.
Dalton transactions (Cambridge, England : 2003), (36)(36), 7428-7436 (2009-09-04)
The reactions of 3,5-dimethylpyrazole with zinc(II)acetate dihydrate and varieties of aromatic carboxylic acids led to formation of mono-nuclear zinc complexes of composition [Zn(HDMP)2(RCO2)2] (R = C6H5, p-CH3-C6H4, p-NO2-C6H4 etc. HDMP = 3,5-dimethylpyrazole) in methanol, whereas the same reactants in dimethylformamide
Sara Straniero et al.
Rejuvenation research, 12(2), 77-84 (2009-05-08)
Aging is characterized by several metabolic changes responsible for the decline of certain functions and the appearance of age-related diseases, including hypercholesterolemia, which is the main risk factor for atherosclerosis and cardiovascular disease. Similar changes in a number of morphological
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