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Raija K Ahmed et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 37(8), 416-425 (2014-09-10)
Human TCRαβ(+) CD4(-)CD8(-) double-negative (DN) T cells represent a minor subset in peripheral blood, yet are important in infectious diseases and autoimmune responses. We examined the frequency of DN T cells in 17 patients after allogeneic hematopoietic stem cell transplantation
Yoshinori Makino et al.
Cell communication and signaling : CCS, 13, 35-35 (2015-07-25)
The complex of Dock180/ELMO1 that functions as a bipartite guanine nucleotide exchange factor for Rac is essential for diverse physiological and pathological processes of cells such as cell migration, phagocytosis, and invasion of cancer cells. Among the Src-family tyrosine kinases
Noboru Shibasaki et al.
PloS one, 10(6), e0130980-e0130980 (2015-06-27)
Vascular endothelial growth factor (VEGF) and mammalian target of rapamycin are well-known therapeutic targets for renal cell carcinoma (RCC). Sunitinib is an agent that targets VEGF receptors and is considered to be a standard treatment for metastatic or unresectable clear
Qinghua Dong et al.
British journal of pharmacology, 171(19), 4440-4454 (2014-06-07)
Doxorubicin-based chemotherapy induces cardiotoxicity, which limits its clinical application. We previously reported the protective effects of quercetin against doxorubicin-induced hepatotoxicity. In this study, we tested the effects of quercetin on the expression of Bmi-1, a protein regulating mitochondrial function and
Li Xing et al.
ChemMedChem, 10(4), 715-726 (2015-03-11)
Anisole and fluoroanisoles display distinct conformational preferences, as evident from a survey of their crystal structures. In addition to altering the free ligand conformation, various degrees of fluorination have a strong impact on physicochemical and pharmacokinetic properties. Analysis of anisole
Matthias B Stope et al.
Oncology reports, 32(6), 2380-2386 (2014-09-19)
Drug resistance minimizes the effects of prostate cancer (PC) chemotherapy with docetaxel and is generally considered to be associated with the expression of heat shock protein (HSP) 27 including various cytoprotective pathways. In the present study, we investigated the effects
Yongjian Qiu et al.
The Plant cell, 27(5), 1409-1427 (2015-05-07)
Phytochromes (phys) are red and far-red photoreceptors that control plant development and growth by promoting the proteolysis of a family of antagonistically acting basic helix-loop-helix transcription factors, the PHYTOCHROME-INTERACTING FACTORs (PIFs). We have previously shown that the degradation of PIF1
Maria Hytti et al.
Scientific reports, 5, 17645-17645 (2015-12-02)
Degeneration of retinal pigment epithelial (RPE) cells is a clinical hallmark of age-related macular degeneration (AMD), the leading cause of blindness among aged people in the Western world. Both inflammation and oxidative stress are known to play vital roles in
C-C Tang et al.
Clinical and experimental immunology, 181(2), 275-285 (2015-02-04)
Natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC) has been linked to protection from HIV infection and slower progression towards AIDS. However, antibody-dependent activation of NK cells results in phenotypical alterations similar to those observed on NK cells from individuals
Mark Feldman et al.
PloS one, 9(5), e93225-e93225 (2014-05-07)
Candida albicans is known as a commensal microorganism but it is also the most common fungal pathogen in humans, causing both mucosal and systemic infections. Biofilm-associated C. albicans infections present clinically important features due to their high levels of resistance
Nicholas J Izzo et al.
PloS one, 9(11), e111898-e111898 (2014-11-13)
Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic beta amyloid (Abeta) 1-42 oligomers is proposed to underlie cognitive decline in Alzheimer's disease (AD). Alterations in membrane trafficking induced by Abeta oligomers mediates reduction in neuronal surface receptor expression
Yoann Personne et al.
The Journal of antimicrobial chemotherapy, 69(12), 3236-3243 (2014-08-20)
Effective treatment of Gram-negative bacterial infections is increasingly challenging due to the spread of multidrug-resistant strains and a lack of new antimicrobials in development. Bacterial type I signal peptidases (SPases) represent a highly conserved and essential target for inhibition by
Qingyi Tong et al.
Toxicology and applied pharmacology, 281(2), 166-173 (2014-08-12)
Dioscin has shown cytotoxicity against cancer cells, but its in vivo effects and the mechanisms have not elucidated yet. The purpose of the current study was to assess the antitumor effects and the molecular mechanisms of dioscin. We showed that
Elamparithi Jayamani et al.
Antimicrobial agents and chemotherapy, 59(3), 1728-1737 (2015-01-15)
The rise of multidrug-resistant Acinetobacter baumannii and a concomitant decrease in antibiotic treatment options warrants a search for new classes of antibacterial agents. We have found that A. baumannii is pathogenic and lethal to the model host organism Caenorhabditis elegans
E Wielogorska et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 69, 260-266 (2014-04-29)
Endocrine disruptors (EDs) are compounds known to interfere with the endocrine system by disturbing the action or pathways of natural hormones which may lead to infertility or cancer. Our diet is considered to be one of the main exposure routes
Yu-Min He et al.
Journal of natural medicines, 69(3), 303-312 (2015-03-10)
Gentianae Scabrae Radix is a well-known traditional medicine that is used for the treatment of hepatitis, cholecystitis and inflammatory diseases. It consists mainly of secoiridoid glycosides, with representatives of gentiopicroside, sweroside and swertiamarin. In the present study, a chemical investigation
Omar Niss et al.
The Journal of allergy and clinical immunology, 135(3), 762-770 (2014-09-02)
Autoimmune lymphoproliferative syndrome (ALPS) is a human disorder of T cell homeostasis caused by mutations that impair FAS-mediated apoptosis. A defining characteristic of ALPS is the expansion of double negative T cells (DNTC). Relatively little is known about how defective
Zi-Ming Chen et al.
Fitoterapia, 102, 61-66 (2015-02-24)
Five new triquinane-type sesquiterpenes, antrodins A-E (1-5) and a new gymnomitrane sesquiterpene, antrodin F (6), together with three known compounds 7-9 were isolated from fermentation of Antrodiella albocinnamomea. Their structures were elucidated through extensive spectroscopic methods including 2D NMR and
Rajmohan Rajamuthiah et al.
PloS one, 10(4), e0124595-e0124595 (2015-04-22)
Staphylococcus aureus is a Gram-positive bacterium that has become the leading cause of hospital acquired infections in the US. Repurposing Food and Drug Administration (FDA) approved drugs for antimicrobial therapy involves lower risks and costs compared to de novo development
Jeanine Alterio et al.
Traffic (Copenhagen, Denmark), 16(9), 978-993 (2015-06-17)
Yif1B is an intracellular membrane-bound protein belonging to the Yip family, shown previously to control serotonin 5-HT1A receptor targeting to dendrites. Because some Yip proteins are involved in the intracellular traffic between the ER and the Golgi, here we investigated
Sara De Martin et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1617-1626 (2014-07-18)
Conflicting results have been obtained by clinical studies investigating the effect of liver cirrhosis on enzyme induction. Because ethical concerns do not give consent for methodologically rigorous studies in humans, we addressed this question by examining the effect of the
Ana Karina Rodrigues Abadio et al.
PloS one, 10(11), e0142926-e0142926 (2015-11-17)
The prevalence of invasive fungal infections worldwide has increased in the last decades. The development of specific drugs targeting pathogenic fungi without producing collateral damage to mammalian cells is a daunting pharmacological challenge. Indeed, many of the toxicities and drug
Julien Salamun et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(11), 4729-4747 (2014-08-13)
Coronins are involved in the regulation of actin dynamics in a multifaceted way, participating in cell migration and vesicular trafficking. Apicomplexan parasites, which exhibit an actin-dependent gliding motility that is essential for traversal through tissues, as well as invasion of
Chan Wang et al.
Materials science & engineering. C, Materials for biological applications, 41, 134-141 (2014-06-09)
As a kind of antimicrobial agent, nano-silver composites have attracted a great deal of interest in biomedical applications. However, the typical loadings of silver nanoparticles (AgNPs) in such composites could result in dose-related cytotoxicity. In this study, a nano-silver composite
M P Tan et al.
Clinical and experimental immunology, 180(2), 255-270 (2014-12-17)
Antigen-specific T cell receptor (TCR) gene transfer via patient-derived T cells is an attractive approach to cancer therapy, with the potential to circumvent immune regulatory networks. However, high-affinity tumour-specific TCR clonotypes are typically deleted from the available repertoire during thymic
Sameer A Dhayat et al.
PloS one, 10(11), e0143755-e0143755 (2015-11-26)
No reliable predictors of susceptibility to gemcitabine chemotherapy exist in pancreatic ductal adenocarcinoma (PDAC). MicroRNAs (miR) are epigenetic gene regulators with tumorsuppressive or oncogenic roles in various carcinomas. This study assesses chemoresistant PDAC for its specific miR expression pattern. Gemcitabine-resistant
Marie Levade et al.
Blood, 124(26), 3991-3995 (2014-10-12)
The oral Bruton's tyrosine kinase inhibitor, ibrutinib, has recently demonstrated high efficiency in patients with relapsed B-cell malignancies. Occurrence of bleeding events has been reported in a subgroup of ibrutinib-treated patients. We demonstrate that ibrutinib selectively inhibits platelet signaling and
Xiali Zhu et al.
Journal of drug targeting, 22(9), 822-828 (2014-06-26)
This report focuses on the in vitro and in vivo anti-cancer effects evaluation of targeting and photothermal sensitive solid lipid nanoparticles (SLN) for the co-loading of docetaxel (DTX), oxidized single-walled carbon nanotubes (OSWNT) and folic acid (FA). Compared with free
Jorge Boucas et al.
PloS one, 10(5), e0125745-e0125745 (2015-05-21)
Growing evidence suggests a key role for RNA binding proteins (RBPs) in genome stability programs. Additionally, recent developments in RNA sequencing technologies, as well as mass-spectrometry techniques, have greatly expanded our knowledge on protein-RNA interactions. We here use full transcriptome
Chiu-Li Kao et al.
Molecules (Basel, Switzerland), 20(6), 11508-11523 (2015-06-26)
Pluchea indica is used in traditional medicine for the treatment of lumbago, ulcer, tuberculosis and inflammation. The anti-cancer activities and the underlying molecular mechanisms of the ethanolic extracts of P. indica root (PIRE) were characterized in the present study. PIRE
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